Proximal tubule transport (WP4917)
Homo sapiens
This pathway provides an overview of all active transport that occurs in the proximal tubule of the nephron in the kidneys. The proximal tubule plays roles in regulating the pH of the filtrate, secreting organic waste, and reabsorption of NaCl, a large variety of solutes, and amino acids from the filtrate back into the circulation. The apical side indicates the proximal tubule which contains the filtrate after passing through Bowman's capsule, which later becomes the urine after passing through the complete nephron, from which solutes are reabsorbed (taken back into the body) and into which waste is secreted. Impaired ability of reabsorption by the proximal tubule can lead to Fanconi syndrome.
Authors
Marvin Martens , Anna Baya Meuleman , Friederike Ehrhart , Finterly Hu , Eric Weitz , and Aishwarya IyerActivity
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Organisms
Homo sapiensCommunities
Serious Request 2024 - MetaKidsAnnotations
Pathway Ontology
transport pathwayCell Type Ontology
kidney cell epithelial cell of proximal tubuleDisease Ontology
Fanconi syndrome| Label | Type | Compact URI | Comment |
|---|---|---|---|
| Cys | Metabolite | chebi:17376 | |
| organic anion | Metabolite | chebi:25696 | |
| organic cation | Metabolite | chebi:25697 | |
| Pro | Metabolite | chebi:26271 | |
| oxalate(2−) | Metabolite | chebi:30623 | |
| formate | Metabolite | chebi:15740 | |
| I- | Metabolite | chebi:16382 | |
| Lactate | Metabolite | chebi:24996 | |
| Na+ | Metabolite | chebi:29101 | |
| urate | Metabolite | chebi:46818 | |
| Gly | Metabolite | chebi:15428 | |
| Ala | Metabolite | chebi:16449 | |
| HPO4 2- | Metabolite | chebi:43474 | |
| OH- | Metabolite | chebi:16234 | |
| Cationic amino acids | Metabolite | chebi:58942 | |
| Amino acids | Metabolite | chebi:33709 | |
| sulfate | Metabolite | chebi:16189 | |
| hydrogencarbonate | Metabolite | chebi:17544 | |
| α-ketoglutarate | Metabolite | chebi:16810 | |
| K+ | Metabolite | chebi:29103 | |
| H+ | Metabolite | chebi:15378 | |
| Cl- | Metabolite | chebi:17996 | |
| H2CO3 | Metabolite | chebi:28976 | |
| H2O | Metabolite | chebi:15377 | |
| CO2 | Metabolite | chebi:16526 | |
| HCO3- | Metabolite | chebi:17544 | |
| Glucose | Metabolite | chebi:17234 | |
| Anionic amino acids | Metabolite | chebi:64898 | |
| H2PO4- | Metabolite | chebi:39745 | |
| H2PO4 - | Metabolite | chebi:39745 | |
| SLC47A2 | GeneProduct | ensembl:ENSG00000180638 | |
| ABCG2 | GeneProduct | ensembl:ENSG00000118777 | |
| SLC7A8 | GeneProduct | ensembl:ENSG00000092068 | |
| SLC47A1 | GeneProduct | ensembl:ENSG00000142494 | |
| ATP6V0D2 | GeneProduct | ensembl:ENSG00000147614 | |
| ATP6V0E1 | GeneProduct | ensembl:ENSG00000113732 | |
| SLC22A2 | GeneProduct | ensembl:ENSG00000112499 | |
| SLC7A9 | GeneProduct | ensembl:ENSG00000021488 | |
| SLC5A2 | GeneProduct | ensembl:ENSG00000140675 | |
| ATP1B1 | GeneProduct | ensembl:ENSG00000143153 | |
| CA4 | GeneProduct | ensembl:ENSG00000167434 | |
| SLC34A1 | GeneProduct | ensembl:ENSG00000131183 | |
| ATP6V1D | GeneProduct | ensembl:ENSG00000100554 | |
| SLC1A1 | GeneProduct | ensembl:ENSG00000106688 | |
| SLC5A8 | GeneProduct | ensembl:ENSG00000256870 | |
| SLC6A20 | GeneProduct | ensembl:ENSG00000163817 | |
| SLC4A4 | GeneProduct | ensembl:ENSG00000080493 | |
| ATP6V1H | GeneProduct | ensembl:ENSG00000047249 | |
| SLC12A4 | GeneProduct | ensembl:ENSG00000124067 | |
| ATP6V0A4 | GeneProduct | ensembl:ENSG00000105929 | |
| ATP6V1A | GeneProduct | ensembl:ENSG00000114573 | |
| SLC22A11 | GeneProduct | ensembl:ENSG00000168065 | |
| SLC3A2 | GeneProduct | ensembl:ENSG00000168003 | |
| TMEM27 | GeneProduct | ensembl:ENSG00000147003 | |
| ATP6V0B | GeneProduct | ensembl:ENSG00000117410 | |
| SLC16A10 | GeneProduct | ensembl:ENSG00000112394 | |
| SLC2A1 | GeneProduct | ensembl:ENSG00000117394 | |
| ATP6V1G1 | GeneProduct | ensembl:ENSG00000136888 | |
| SLC34A3 | GeneProduct | ensembl:ENSG00000198569 | |
| ABCC4 | GeneProduct | ensembl:ENSG00000125257 | |
| ATP1A1 | GeneProduct | ensembl:ENSG00000163399 | |
| SLC9A3 | GeneProduct | ensembl:ENSG00000066230 | |
| ABCB1 | GeneProduct | ensembl:ENSG00000085563 | |
| SLC5A5 | GeneProduct | ensembl:ENSG00000105641 | |
| FXYD2 | GeneProduct | ensembl:ENSG00000137731 | |
| SLC7A7 | GeneProduct | ensembl:ENSG00000155465 | |
| SLC6A19 | GeneProduct | ensembl:ENSG00000174358 | |
| ATP6V1F | GeneProduct | ensembl:ENSG00000128524 | |
| ATP6V1B1 | GeneProduct | ensembl:ENSG00000116039 | |
| SLC4A2 | GeneProduct | ensembl:ENSG00000164889 | |
| SLC36A2 | GeneProduct | ensembl:ENSG00000186335 | |
| ABCC2 | GeneProduct | ensembl:ENSG00000023839 | |
| ATP6V1C1 | GeneProduct | ensembl:ENSG00000155097 | |
| SLC6A18 | GeneProduct | ensembl:ENSG00000164363 | |
| SLC2A2 | GeneProduct | ensembl:ENSG00000163581 | |
| ATP6V1E1 | GeneProduct | ensembl:ENSG00000131100 | |
| SLC26A6 | GeneProduct | ensembl:ENSG00000225697 | |
| SLC20A2 | GeneProduct | ensembl:ENSG00000168575 | |
| ATP6V0C | GeneProduct | ensembl:ENSG00000185883 | |
| SLC3A1 | GeneProduct | ensembl:ENSG00000138079 | |
| AQP1 | GeneProduct | ensembl:ENSG00000240583 | |
| CA2 | GeneProduct | ensembl:ENSG00000104267 | |
| SLC5A1 | GeneProduct | ensembl:ENSG00000100170 | |
| SLC22A7 | GeneProduct | ensembl:ENSG00000137204 | |
| SLC22A6 | GeneProduct | ensembl:ENSG00000197901 | |
| SLC22A8 | GeneProduct | ensembl:ENSG00000149452 | |
| SLC13A3 | GeneProduct | ensembl:ENSG00000158296 |
References
- Renal Physiology [Internet]. Koeppen BM, Stanton BA. Elsevier; 2018. 248 p. Available from: https://books.google.com/books/about/Renal_Physiology.html?hl=&id=yDFStgEACAAJ OpenLibrary Worldcat
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- Renal vacuolar H+-ATPase. Wagner CA, Finberg KE, Breton S, Marshansky V, Brown D, Geibel JP. Physiol Rev. 2004 Oct;84(4):1263–314. PubMed Europe PMC Scholia
- Essential roles of CFEX-mediated Cl(-)-oxalate exchange in proximal tubule NaCl transport and prevention of urolithiasis. Aronson PS. Kidney Int. 2006 Oct;70(7):1207–13. PubMed Europe PMC Scholia
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- Acid-base transport by the renal proximal tubule. Skelton LA, Boron WF, Zhou Y. J Nephrol. 2010;23 Suppl 16(0 16):S4-18. PubMed Europe PMC Scholia
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