Host-pathogen interaction of human coronaviruses - autophagy (WP4863)

Homo sapiens

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This pathway describes the induction and modulation of the human autophagy system during human coronavirus infection. The information is based on the review of Fung and Liu [10.1146/annurev-micro-020518-115759]. Autophagy is usually a stress mediated defense mechanism and can protect against pathogen infection. On the other hand it is known from several viruses that they can hijack the cellular autophagy system for proliferation [10.1074/jbc.M306124200]. For human coronaviruses it is presumed that coronaviruses stimulate the initiation of autophagy due to infection initiated stress for which PIK3R4 (VPS15), PIK3C3 (VPS34) and BECN1 (beclin1) are key proteins. Additionally, nsp6 (and nsp567 from other virus species than SARS-CoV) inhibit maturation of autolysosomes. Nsp6 is involved in the formation of double membrane vesicles and therefore has side effects on the formation of normal cellular vesicles [10.4161/auto.29309].

Authors

Friederike Ehrhart , Alex Pico , Egon Willighagen , Kristina Hanspers , Martina Summer-Kutmon , and Eric Weitz

Activity

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Organisms

Homo sapiens

Communities

COVID-19

Annotations

Disease Ontology

viral infectious disease severe acute respiratory syndrome

Pathway Ontology

disease pathway autophagy pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
PE Metabolite chebi:16038
ATG13 GeneProduct ensembl:ENSG00000175224
LC3 GeneProduct uniprot:Q9H492
ULK1 Protein uniprot:O75385
ULK2 Protein uniprot:Q8IYT8
RB1CC1 Protein uniprot:Q8TDY2 FIP200
BECN1 Protein uniprot:Q14457 beclin 1
PIK3R4 Protein uniprot:Q99570 VPS15
MTOR Protein uniprot:P42345
PIK3C3 Protein uniprot:Q8NEB9 VPS34
WIPI1 Protein uniprot:Q5MNZ9
ZFYVE1 Protein uniprot:Q9HBF4
ATG7 Protein uniprot:O95352
ATG10 Protein uniprot:Q9H0Y0
ATG5 Protein uniprot:Q9H1Y0
ATG12 Protein uniprot:O94817
ATG16L1 Protein uniprot:Q676U5
ATG3 Protein uniprot:Q9NT62
ATG4A Protein uniprot:Q8WYN0
ATG16L2 Protein uniprot:Q8NAA4
ATG13 Protein uniprot:O75143
nsp6 Protein ncbiprotein:YP_009725302

References

  1. Coronavirus NSP6 restricts autophagosome expansion. Cottam EM, Whelband MC, Wileman T. Autophagy. 2014 Aug;10(8):1426–41. PubMed Europe PMC Scholia
  2. Human Coronavirus: Host-Pathogen Interaction. Fung TS, Liu DX. Annu Rev Microbiol. 2019 Sep 8;73:529–57. PubMed Europe PMC Scholia