Glycosaminoglycan degradation (WP4815)

Homo sapiens

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Taken from KEGG: Glycosaminoglycan degradation - Homo sapiens (human) [https://www.genome.jp/kegg-bin/show_pathway?hsa00531]. Some genes such as NAGZ could not be found, these have been left on the diagram as unannotated GeneProducts. Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutation in the respective gene.

Authors

Ritchie Lee , Kristina Hanspers , and Egon Willighagen

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

Skeletal Dysplasia

Annotations

Pathway Ontology

glycosaminoglycan degradation pathway classic metabolic pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
Dermatan sulfate Metabolite chebi:18376
Keratan sulfate Metabolite chebi:18331
hyaluronan Metabolite chebi:132153
(GalNAc)1 (GlcA)1 (S)1 Metabolite kegg.glycan:G00872
(GlcA)1 (GlcNAc)2 Metabolite kegg.glycan:G00711
(GlcA)2 (GlcNAc)2 Metabolite kegg.glycan:G00526
Heparan sulfate Metabolite chebi:28815
(GalNAc)2 (GlcA)1 (LIdoA)1 (S)3 Metabolite kegg.glycan:G13041
(GlcA)1 (GlcNAc)1 Metabolite kegg.glycan:G10008
(GlcA)2 (GlcN)1 (GlcNAc)1 (LIdoA)1 (S)4 Metabolite kegg.glycan:G13034
(GlcA)1 (GlcNAc)1 (S)1 Metabolite kegg.glycan:G09660
(GalNAc)2 (GlcA)1 (S)2 Metabolite kegg.glycan:G12336
(GalNAc)2 (GlcA)1 (LIdoA)1 (S)2 Metabolite kegg.glycan:G13042
(GlcA)2 (GlcN)1 (GlcNAc)1 (LIdoA)1 (S)3 Metabolite kegg.glycan:G13035
(GalNAc)2 (GlcA)1 (S)1 Metabolite kegg.glycan:G13043
(GlcA)2 (GlcNAc)1 (S)1 Metabolite kegg.glycan:G13040
Chondroitin sulfate Metabolite chebi:37397
(GlcA)2 (GlcN)1 (GlcNAc)1 (S)3 Metabolite kegg.glycan:G13036
(GlcA)2 (GlcN)1 (GlcNAc)1 (S)2 Metabolite kegg.glycan:G13037
(GlcA)2 (GlcNAc)2 (S)2 Metabolite kegg.glycan:G13038
(GlcA)2 (GlcNAc)1 (S)2 Metabolite kegg.glycan:G13039
(GlcA)1 (GlcNAc)1 Metabolite kegg.glycan:G02632
(Gal)2 (GlcNAc)2 (S)3 Metabolite kegg.glycan:G01945
(Gal)2 (GlcNAc)2 (S)2 Metabolite kegg.glycan:G01977
(Gal)1 (GlcNAc)2 (S)2 Metabolite kegg.glycan:G13073
(Gal)1 (GlcNAc)2 (S)1 Metabolite kegg.glycan:G13074
(Gal)1 (GlcNAc)1 (S)1 Metabolite kegg.glycan:G01391
GNS GeneProduct ensembl:ENSG00000135677
HPSE GeneProduct ensembl:ENSG00000173083
GUSB GeneProduct ensembl:ENSG00000169919
GNS GeneProduct ensembl:ENSG00000135677
ARSB GeneProduct ensembl:ENSG00000113273
IDUA GeneProduct ensembl:ENSG00000127415
GUSB GeneProduct ensembl:ENSG00000169919
HEXA GeneProduct ensembl:ENSG00000213614
HYAL2 GeneProduct ensembl:ENSG00000068001
SGSH GeneProduct ensembl:ENSG00000181523
IDS GeneProduct ensembl:ENSG00000010404
GALNS GeneProduct ensembl:ENSG00000141012
GUSB GeneProduct ensembl:ENSG00000169919
HPSE2 GeneProduct ensembl:ENSG00000172987
HYAL4 GeneProduct ensembl:ENSG00000106302
GLB1 GeneProduct ensembl:ENSG00000170266
HYAL4 GeneProduct ensembl:ENSG00000106302
HYAL1 GeneProduct ensembl:ENSG00000114378
HGSNAT GeneProduct ensembl:ENSG00000165102
NAGLU GeneProduct ensembl:ENSG00000108784
GALNS GeneProduct ensembl:ENSG00000141012
HYAL4 GeneProduct ensembl:ENSG00000106302
IDUA GeneProduct ensembl:ENSG00000127415
IDS GeneProduct ensembl:ENSG00000010404
HEXB GeneProduct ensembl:ENSG00000049860
HEXA GeneProduct ensembl:ENSG00000213614
HEXB GeneProduct ensembl:ENSG00000049860
GUSB GeneProduct ensembl:ENSG00000169919
GUSB GeneProduct ensembl:ENSG00000169919
ARSB GeneProduct ensembl:ENSG00000113273
IDUA GeneProduct ensembl:ENSG00000127415
IDS GeneProduct ensembl:ENSG00000010404
HYAL4 GeneProduct ensembl:ENSG00000106302
HYAL4 GeneProduct ensembl:ENSG00000106302
GUSB GeneProduct ensembl:ENSG00000169919
ARSB GeneProduct ensembl:ENSG00000113273
GNS GeneProduct ensembl:ENSG00000135677
HPSE GeneProduct ensembl:ENSG00000173083
GUSB GeneProduct ensembl:ENSG00000169919
SGSH GeneProduct ensembl:ENSG00000181523
HPSE2 GeneProduct ensembl:ENSG00000172987
NAGLU GeneProduct ensembl:ENSG00000108784
NAGLU GeneProduct ensembl:ENSG00000108784
IDUA GeneProduct ensembl:ENSG00000127415
IDS GeneProduct ensembl:ENSG00000010404
GNS GeneProduct ensembl:ENSG00000135677
GALNS GeneProduct ensembl:ENSG00000141012
HEXA GeneProduct ensembl:ENSG00000213614
HEXB GeneProduct ensembl:ENSG00000049860
GNS GeneProduct ensembl:ENSG00000135677
HEXA GeneProduct ensembl:ENSG00000213614
HEXB GeneProduct ensembl:ENSG00000049860
GLB1 GeneProduct ensembl:ENSG00000170266
GLB1 GeneProduct ensembl:ENSG00000170266

References