Eicosanoid metabolism via cytochrome P450 monooxygenases pathway (WP4720)

Homo sapiens

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Authors

Denise Slenter , Eric Weitz , and Egon Willighagen

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

Lipids and LIPID MAPS

Annotations

Pathway Ontology

eicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma cytochrome P450 monooxygenase mediated pathway of arachidonic acid metabolism eicosanoid metabolic pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
Arachidonic acid Metabolite lipidmaps:LMFA01030001
16-HETE Metabolite lipidmaps:LMFA03090010
17-HETE Metabolite lipidmaps:LMFA03060091
18-HETE Metabolite lipidmaps:LMFA03060092
19-HETE Metabolite lipidmaps:LMFA03060106
20-HETE Metabolite lipidmaps:LMFA03060009
5,6-EpETrE Metabolite lipidmaps:LMFA03080002
8,9-EpETrE Metabolite lipidmaps:LMFA03080003
11,12-EpETrE Metabolite lipidmaps:LMFA03090010
14,15-EpETrE Metabolite lipidmaps:LMFA03080005
5,6-DiHETrE Metabolite lipidmaps:LMFA03050004
8,9-DiHETrE Metabolite lipidmaps:LMFA03050006
11,12-DiHETrE Metabolite lipidmaps:LMFA03050008
14,15-DiHETrE Metabolite lipidmaps:LMFA03050010
EPHX2 GeneProduct ensembl:ENSG00000120915 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13850
CYP4A11 GeneProduct ensembl:ENSG00000187048 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13117
CYP4A22 GeneProduct ensembl:ENSG00000162365 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:277753
CYP4A22 GeneProduct ensembl:ENSG00000162365 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13118
CYP4F12 GeneProduct ensembl:ENSG00000186204 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:64385
CYP4F2 GeneProduct ensembl:ENSG00000186115 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:72054
PPAR gamma Protein uniprot:P37231 AKA Peroxisome proliferator-activated receptor gamma
CYP2C8 Protein ensembl:ENSG00000138115 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13095
CYP2C8 Protein ensembl:ENSG00000138115 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13097
CYP2C8 Protein ensembl:ENSG00000138115 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13098
CYP2C18 Protein ensembl:ENSG00000108242 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:72082
PPARA Protein ensembl:ENSG00000186951 AKA Peroxisome proliferator-activated receptor alpha
Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:P23204

References

  1. A mouse macrophage lipidome. Dennis EA, Deems RA, Harkewicz R, Quehenberger O, Brown HA, Milne SB, et al. J Biol Chem. 2010 Dec 17;285(51):39976–85. PubMed Europe PMC Scholia
  2. Eicosanoid storm in infection and inflammation. Dennis EA, Norris PC. Nat Rev Immunol. 2015 Aug;15(8):511–23. PubMed Europe PMC Scholia