Lipids measured in liver metastasis from breast cancer (WP4627)

Mus musculus

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These pathways show lipids involved in the liver metastasis from breast cancer. In many conversions of these metabolites the proteins which catalyse these reactions are unknown because of the limited research in this field.

Authors

Chris Gillissen , Denise Slenter , Egon Willighagen , Alex Pico , Kristina Hanspers , Friederike Ehrhart , and Martina Summer-Kutmon

Activity

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Organisms

Mus musculus

Communities

Annotations

Pathway Ontology

disease pathway lipid metabolic pathway cancer pathway

Disease Ontology

breast cancer

Participants

Label Type Compact URI Comment
(9Z)-octa-decenoyl-CoA Metabolite chebi:57387
1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-cytidine-5ʼ-diphosphate Metabolite chebi:85353
1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate Metabolite lipidmaps:LMGP10010037
CoA Metabolite chebi:57287
1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol Metabolite chebi:75468
1-octadecanoyl-sn-glycero-3-phosphate Metabolite chebi:74565
(9Z,12Z)-octadecadienoyl-CoA Metabolite chebi:57383
1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) Metabolite chebi:72837
(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA Metabolite chebi:57368
1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-D-myo-inositol Metabolite chebi:72834
(9Z)-octadecenoate Metabolite chebi:30823
octadecanoyl-CoA Metabolite chebi:57394
1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) Metabolite chebi:72835
1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) Metabolite chebi:72833
1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) Metabolite chebi:75160
hexadecanoyl-CoA Metabolite chebi:57379
(9Z)-octadecenoyl-CoA Metabolite chebi:57387
dodecanoyl-CoA Metabolite chebi:57375
1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1D-myo-inositol) Metabolite chebi:72838
1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) Metabolite chebi:72836
1-(9Z-octadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-1D-myo-inositol Metabolite chebi:78765
sn-glycero-3-phospho-1D-myo-inositol Metabolite chebi:58444
1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) Metabolite chebi:78762
Coenzyme A(4-) Metabolite chebi:57287
1-octadecanoyl-2-(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-sn-glycero-3-phospho-1D-myo-inositol Metabolite lipidmaps:LMGP06010854
1-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) Metabolite chebi:74243
(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA(4-) Metabolite chebi:73862
all-trans-retinyl dodecanoate Metabolite chebi:140089
All-trans-retinol Metabolite chebi:17336
amino acid residue Metabolite chebi:83228
1,2-didodecanoyl-sn-glycero-3-phosphocholine Metabolite lipidmaps:LMGP01010429
2-dodecanoyl-sn-glycero-3-phosphocholine Metabolite chebi:140088
Phosphatidate phosphatase LPIN1 Protein uniprot:Q14693
ABHD5 Protein uniprot:Q8WTS1 There are different isoforms of AGPAT. The articles mention isoforms 3,5 and 11, but perhaps there are other isoforms which could catalyze this reaction. I have not yet looked into this.
Protein name: 1-acylglycerol-3-phosphate O-acyltransferase
Diacylglycerol kinase zeta Protein uniprot:E9PK94
Phosphatidate cytidylyl-transferase 1 Protein uniprot:Q92903
Lysophospholipid acyltransferase 7 Protein uniprot:Q96N66
Lecithin retinol acyltransferase Protein uniprot:Q9JI60

References

  1. Molecular cloning and characterization of a novel human diacylglycerol kinase zeta. Bunting M, Tang W, Zimmerman GA, McIntyre TM, Prescott SM. J Biol Chem. 1996 Apr 26;271(17):10230–6. PubMed Europe PMC Scholia
  2. Alternative splicing of the human diacylglycerol kinase zeta gene in muscle. Ding L, Bunting M, Topham MK, McIntyre TM, Zimmerman GA, Prescott SM. Proc Natl Acad Sci U S A. 1997 May 27;94(11):5519–24. PubMed Europe PMC Scholia
  3. Caenorhabditis elegans mboa-7, a member of the MBOAT family, is required for selective incorporation of polyunsaturated fatty acids into phosphatidylinositol. Lee HC, Inoue T, Imae R, Kono N, Shirae S, Matsuda S, et al. Mol Biol Cell. 2008 Mar;19(3):1174–84. PubMed Europe PMC Scholia
  4. CGI-58/ABHD5 is a coenzyme A-dependent lysophosphatidic acid acyltransferase. Montero-Moran G, Caviglia JM, McMahon D, Rothenberg A, Subramanian V, Xu Z, et al. J Lipid Res. 2010 Apr;51(4):709–19. PubMed Europe PMC Scholia
  5. Characterization of the human LPIN1-encoded phosphatidate phosphatase isoforms. Han GS, Carman GM. J Biol Chem. 2010 May 7;285(19):14628–38. PubMed Europe PMC Scholia
  6. Enzymatic activity of the human 1-acylglycerol-3-phosphate-O-acyltransferase isoform 11: upregulated in breast and cervical cancers. Agarwal AK, Garg A. J Lipid Res. 2010 Aug;51(8):2143–52. PubMed Europe PMC Scholia
  7. An acyl-covalent enzyme intermediate of lecithin:retinol acyltransferase. Golczak M, Palczewski K. J Biol Chem. 2010 Sep 17;285(38):29217–22. PubMed Europe PMC Scholia
  8. Enzymatic activities of the human AGPAT isoform 3 and isoform 5: localization of AGPAT5 to mitochondria. Prasad SS, Garg A, Agarwal AK. J Lipid Res. 2011 Mar;52(3):451–62. PubMed Europe PMC Scholia
  9. ABHD12 controls brain lysophosphatidylserine pathways that are deregulated in a murine model of the neurodegenerative disease PHARC. Blankman JL, Long JZ, Trauger SA, Siuzdak G, Cravatt BF. Proc Natl Acad Sci U S A. 2013 Jan 22;110(4):1500–5. PubMed Europe PMC Scholia
  10. Distinct properties of the two isoforms of CDP-diacylglycerol synthase. D’Souza K, Kim YJ, Balla T, Epand RM. Biochemistry. 2014 Dec 2;53(47):7358–67. PubMed Europe PMC Scholia