Acute viral myocarditis (WP4298)

Homo sapiens

Authors

Olivier Traets , Friederike Ehrhart , Egon Willighagen , Kristina Hanspers , Marvin Martens , Eric Weitz , and Finterly Hu

Activity

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Cited In

• An NF-κB- and Therapy-Related Regulatory Network in Glioma: A Potential Mechanism of Action for Natural Antiglioma Agents (2022).
• IL6-mediated HCoV-host interactome regulatory network and GO/Pathway enrichment analysis (2020).
• Construction and analysis of protein-protein interaction network of non-alcoholic fatty liver disease.

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Organisms

Homo sapiens

Communities

Diseases Rare Diseases

Annotations

Cell Type Ontology

professional antigen presenting cell CD4-positive, alpha-beta T cell CD8-positive, alpha-beta T cell cardiac muscle cell B cell

Disease Ontology

viral infectious disease myocarditis

Pathway Ontology

cardiomyopathy pathway disease pathway myocarditis pathway

References

1. Detection of Coxsackie-B-virus-specific RNA sequences in myocardial biopsy samples from patients with myocarditis and dilated cardiomyopathy. Bowles NE, Richardson PJ, Olsen EG, Archard LC. Lancet. 1986 May 17;1(8490):1120–3. PubMed Europe PMC Scholia
2. Complete nucleotide sequence of the genome of coxsackievirus B1. Iizuka N, Kuge S, Nomoto A. Virology. 1987 Jan;156(1):64–73. PubMed Europe PMC Scholia
3. Adenovirus inhibition of cell translation facilitates release of virus particles and enhances degradation of the cytokeratin network. Zhang Y, Schneider RJ. J Virol. 1994 Apr;68(4):2544–55. PubMed Europe PMC Scholia
4. Mechanisms of immune-mediated myocyte injury. Barry WH. Circulation. 1994 May;89(5):2421–32. PubMed Europe PMC Scholia
5. The structure of coxsackievirus B3 at 3.5 A resolution. Muckelbauer JK, Kremer M, Minor I, Diana G, Dutko FJ, Groarke J, et al. Structure. 1995 Jul 15;3(7):653–67. PubMed Europe PMC Scholia
6. Tyrosine phosphorylation events during coxsackievirus B3 replication. Huber M, Selinka HC, Kandolf R. J Virol. 1997 Jan;71(1):595–600. PubMed Europe PMC Scholia
7. Isolation of a common receptor for Coxsackie B viruses and adenoviruses 2 and 5. Bergelson JM, Cunningham JA, Droguett G, Kurt-Jones EA, Krithivas A, Hong JS, et al. Science. 1997 Feb 28;275(5304):1320–3. PubMed Europe PMC Scholia
8. DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis. Liu X, Zou H, Slaughter C, Wang X. Cell. 1997 Apr 18;89(2):175–84. PubMed Europe PMC Scholia
9. The genetics of dilated cardiomyopathy--emerging clues to the puzzle. Leiden JM. N Engl J Med. 1997 Oct 9;337(15):1080–1. PubMed Europe PMC Scholia
10. Dilated cardiomyopathy in transgenic mice expressing a dominant-negative CREB transcription factor in the heart. Fentzke RC, Korcarz CE, Lang RM, Lin H, Leiden JM. J Clin Invest. 1998 Jun 1;101(11):2415–26. PubMed Europe PMC Scholia
11. Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Li H, Zhu H, Xu CJ, Yuan J. Cell. 1998 Aug 21;94(4):491–501. PubMed Europe PMC Scholia
12. Incidence of dilated cardiomyopathy and detection of HIV in myocardial cells of HIV-positive patients. Gruppo Italiano per lo Studio Cardiologico dei Pazienti Affetti da AIDS. Barbaro G, Di Lorenzo G, Grisorio B, Barbarini G. N Engl J Med. 1998 Oct 15;339(16):1093–9. PubMed Europe PMC Scholia
13. Coxsackievirus and adenovirus receptor cytoplasmic and transmembrane domains are not essential for coxsackievirus and adenovirus infection. Wang X, Bergelson JM. J Virol. 1999 Mar;73(3):2559–62. PubMed Europe PMC Scholia
14. Cleavage of RasGAP and phosphorylation of mitogen-activated protein kinase in the course of coxsackievirus B3 replication. Huber M, Watson KA, Selinka HC, Carthy CM, Klingel K, McManus BM, et al. J Virol. 1999 May;73(5):3587–94. PubMed Europe PMC Scholia
15. Structural analysis of the mechanism of adenovirus binding to its human cellular receptor, CAR. Bewley MC, Springer K, Zhang YB, Freimuth P, Flanagan JM. Science. 1999 Nov 19;286(5444):1579–83. PubMed Europe PMC Scholia
16. Apoptosis in coxsackievirus B3-caused diseases: interaction between the capsid protein VP2 and the proapoptotic protein siva. Henke A, Launhardt H, Klement K, Stelzner A, Zell R, Munder T. J Virol. 2000 May;74(9):4284–90. PubMed Europe PMC Scholia
17. 2A proteinase of human rhinovirus cleaves cytokeratin 8 in infected HeLa cells. Seipelt J, Liebig HD, Sommergruber W, Gerner C, Kuechler E. J Biol Chem. 2000 Jun 30;275(26):20084–9. PubMed Europe PMC Scholia
18. Enteroviral cardiomyopathy: bad news for the dystrophin-glycoprotein complex. Badorff C, Lee GH, Knowlton KU. Herz. 2000 May;25(3):227–32. PubMed Europe PMC Scholia
19. Interaction of coxsackievirus B3 with the full length coxsackievirus-adenovirus receptor. He Y, Chipman PR, Howitt J, Bator CM, Whitt MA, Baker TS, et al. Nat Struct Biol. 2001 Oct;8(10):874–8. PubMed Europe PMC Scholia
20. Essential role of HIV type 1-infected and cyclooxygenase 2-activated macrophages and T cells in HIV type 1 myocarditis. Liu QN, Reddy S, Sayre JW, Pop V, Graves MC, Fiala M. AIDS Res Hum Retroviruses. 2001 Oct 10;17(15):1423–33. PubMed Europe PMC Scholia
21. Pathogenesis of HIV-associated cardiomyopathy. Barbaro G, Lipshultz SE. Ann N Y Acad Sci. 2001 Nov;946:57–81. PubMed Europe PMC Scholia
22. Bax and BH3-domain-only proteins in p53-mediated apoptosis. Wu X, Deng Y. Front Biosci. 2002 Jan 1;7:d151-6. PubMed Europe PMC Scholia
23. Cardiomyocytes undergo apoptosis in human immunodeficiency virus cardiomyopathy through mitochondrion- and death receptor-controlled pathways. Twu C, Liu NQ, Popik W, Bukrinsky M, Sayre J, Roberts J, et al. Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14386–91. PubMed Europe PMC Scholia
24. Individual expression of poliovirus 2Apro and 3Cpro induces activation of caspase-3 and PARP cleavage in HeLa cells. Calandria C, Irurzun A, Barco A, Carrasco L. Virus Res. 2004 Aug;104(1):39–49. PubMed Europe PMC Scholia
25. HIV-1 induces cardiomyopathyby cardiomyocyte invasion and gp120, Tat, and cytokine apoptotic signaling. Fiala M, Popik W, Qiao JH, Lossinsky AS, Alce T, Tran K, et al. Cardiovasc Toxicol. 2004;4(2):97–107. PubMed Europe PMC Scholia
26. Autoimmune myocarditis: cellular mediators of cardiac dysfunction. Afanasyeva M, Georgakopoulos D, Rose NR. Autoimmun Rev. 2004 Nov;3(7–8):476–86. PubMed Europe PMC Scholia
27. Translational control in stress and apoptosis. Holcik M, Sonenberg N. Nat Rev Mol Cell Biol. 2005 Apr;6(4):318–27. PubMed Europe PMC Scholia
28. DAP5 and IRES-mediated translation during programmed cell death. Marash L, Kimchi A. Cell Death Differ. 2005 Jun;12(6):554–62. PubMed Europe PMC Scholia
29. HIV-associated cardiomyopathy etiopathogenesis and clinical aspects. Barbaro G. Herz. 2005 Sep;30(6):486–92. PubMed Europe PMC Scholia
30. Apoptosis-inducing factor mediates poly(ADP-ribose) (PAR) polymer-induced cell death. Yu SW, Andrabi SA, Wang H, Kim NS, Poirier GG, Dawson TM, et al. Proc Natl Acad Sci U S A. 2006 Nov 28;103(48):18314–9. PubMed Europe PMC Scholia
31. Coxsackievirus B3 proteases 2A and 3C induce apoptotic cell death through mitochondrial injury and cleavage of eIF4GI but not DAP5/p97/NAT1. Chau DHW, Yuan J, Zhang H, Cheung P, Lim T, Liu Z, et al. Apoptosis. 2007 Mar;12(3):513–24. PubMed Europe PMC Scholia
32. Molecular biology and pathogenesis of viral myocarditis. Esfandiarei M, McManus BM. Annu Rev Pathol. 2008;3:127–55. PubMed Europe PMC Scholia
33. CVB infection and mechanisms of viral cardiomyopathy. Knowlton KU. Curr Top Microbiol Immunol. 2008;323:315–35. PubMed Europe PMC Scholia
34. Activation of innate immune antiviral responses by Nod2. Sabbah A, Chang TH, Harnack R, Frohlich V, Tominaga K, Dube PH, et al. Nat Immunol. 2009 Oct;10(10):1073–80. PubMed Europe PMC Scholia
35. Myeloid differentiation factor-88/interleukin-1 signaling controls cardiac fibrosis and heart failure progression in inflammatory dilated cardiomyopathy. Blyszczuk P, Kania G, Dieterle T, Marty RR, Valaperti A, Berthonneche C, et al. Circ Res. 2009 Oct 23;105(9):912–20. PubMed Europe PMC Scholia
36. Mechanisms of cardiac fibrosis in inflammatory heart disease. Kania G, Blyszczuk P, Eriksson U. Trends Cardiovasc Med. 2009 Nov;19(8):247–52. PubMed Europe PMC Scholia
37. Endonuclease G interacts with histone H2B and DNA topoisomerase II alpha during apoptosis. Vařecha M, Potěšilová M, Matula P, Kozubek M. Mol Cell Biochem. 2012 Apr;363(1–2):301–7. PubMed Europe PMC Scholia
38. Mechanism of NLRP3 inflammasome activation. Sutterwala FS, Haasken S, Cassel SL. Ann N Y Acad Sci. 2014 Jun;1319(1):82–95. PubMed Europe PMC Scholia
39. NOD2 (Nucleotide-Binding Oligomerization Domain 2) Is a Major Pathogenic Mediator of Coxsackievirus B3-Induced Myocarditis. Tschöpe C, Müller I, Xia Y, Savvatis K, Pappritz K, Pinkert S, et al. Circ Heart Fail. 2017 Sep;10(9):e003870. PubMed Europe PMC Scholia