Phosphodiesterases in neuronal function (WP4222)

Homo sapiens

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Phosphodiesterases are enzymes which break phosphodiester bonds and play an importan role in signaling pathways, especially in second messenger pathways which involve cyclic AMP or GMP.

Authors

Friederike Ehrhart , Egon Willighagen , Cenna Doornbos , and Kristina Hanspers

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

glutamate signaling pathway dopamine signaling pathway neuron-to-neuron signaling pathways

Disease Ontology

Alzheimer's disease Gilles de la Tourette syndrome obsessive-compulsive disorder Huntington's disease Parkinson's disease attention deficit hyperactivity disorder schizophrenia

Cell Type Ontology

neuron

Participants
Query Drugst.One

Label Type Compact URI Comment
AMP Metabolite hmdb:HMDB0003540
L-Glutamate Metabolite chebi:16015
GTP Metabolite chebi:37565
Calcium Metabolite hmdb:HMDB0000464
Cyclic GMP Metabolite hmdb:HMDB0001314
GMP Metabolite hmdb:HMDB0001397
Nitric oxide Metabolite hmdb:HMDB0003378
Rolipram Metabolite chebi:104872
Caffeine Metabolite hmdb:HMDB0001847
Cilostazol Metabolite hmdb:HMDB0015297
Dopamine Metabolite hmdb:HMDB0000073
Sildenafil Metabolite hmdb:HMDB0005039
Cyclic AMP Metabolite hmdb:HMDB0000058
GRIN2A GeneProduct ensembl:ENSG00000183454
GRIN2B GeneProduct ensembl:ENSG00000273079
GRIN2C GeneProduct ensembl:ENSG00000161509
PDE1C GeneProduct ensembl:ENSG00000154678
PDE4C GeneProduct ensembl:ENSG00000105650
PDE3A GeneProduct ensembl:ENSG00000172572
NOS1 GeneProduct ensembl:ENSG00000089250
PDE8B GeneProduct ensembl:ENSG00000113231
ADCY3 GeneProduct ensembl:ENSG00000138031
ADCY1 GeneProduct ensembl:ENSG00000164742
PDE12 GeneProduct ensembl:ENSG00000174840
CREB GeneProduct ensembl:ENSG00000118260
PDE3B GeneProduct ensembl:ENSG00000152270
ADCY4 GeneProduct ensembl:ENSG00000129467
DRD1 GeneProduct ensembl:ENSG00000184845
PDE6C GeneProduct ensembl:ENSG00000095464
ADCY9 GeneProduct ensembl:ENSG00000162104
PDE6A GeneProduct ensembl:ENSG00000132915
PDE4D GeneProduct ensembl:ENSG00000113448
PDE7B GeneProduct ensembl:ENSG00000171408
PDE6B GeneProduct ensembl:ENSG00000133256
ADCY2 GeneProduct ensembl:ENSG00000078295
PDE6D GeneProduct ensembl:ENSG00000156973
PDE9A GeneProduct ensembl:ENSG00000160191
PDE2A GeneProduct ensembl:ENSG00000186642
PDE6G GeneProduct ensembl:ENSG00000185527
PDE6H GeneProduct ensembl:ENSG00000139053
PDE5 GeneProduct ensembl:ENSG00000138735 Also known as PDE5A [uniprot:O76074]
CAMK2A GeneProduct ensembl:ENSG00000070808
GRIN2D GeneProduct ensembl:ENSG00000105464
ADCY8 GeneProduct ensembl:ENSG00000155897
PRKACA GeneProduct ensembl:ENSG00000072062
PDE8A GeneProduct ensembl:ENSG00000073417
ADCY10 GeneProduct ensembl:ENSG00000143199
ADCY6 GeneProduct ensembl:ENSG00000174233
PDE5A GeneProduct ensembl:ENSG00000138735
GRIN1 GeneProduct ensembl:ENSG00000176884
CHRNA7 GeneProduct ensembl:ENSG00000175344
PDE1B GeneProduct ensembl:ENSG00000123360
PDE10A GeneProduct ensembl:ENSG00000112541
PDE11A GeneProduct ensembl:ENSG00000128655
PDE4A GeneProduct ensembl:ENSG00000065989
ADORA2A GeneProduct ensembl:ENSG00000128271
PRKG1 GeneProduct ensembl:ENSG00000185532
ADCY5 GeneProduct ensembl:ENSG00000173175
PDE7A GeneProduct ensembl:ENSG00000205268
GRIA1 GeneProduct ensembl:ENSG00000155511
PDE1A GeneProduct ensembl:ENSG00000115252
DARPP-32 GeneProduct ensembl:ENSG00000131771
DRD2 GeneProduct ensembl:ENSG00000149295
PDE4B GeneProduct ensembl:ENSG00000184588
ADCY7 GeneProduct ensembl:ENSG00000121281
AMPA GeneProduct ensembl:ENSG00000155511
GUCY1A2 GeneProduct ensembl:ENSG00000152402
GUCY1B1 GeneProduct ensembl:ENSG00000061918 Also known as GUCY1B3 [uniprot:Q02153].
GUCY1A1 GeneProduct ensembl:ENSG00000164116 Also known as GUCY1A3 [uniprot:Q02108].
GUCY1B2 GeneProduct ensembl:ENSG00000123201
GUCY1A3 GeneProduct ensembl:ENSG00000164116
GUCY1B3 GeneProduct ensembl:ENSG00000061918

References

  1. Steroidogenesis in isolated adrenal cells of rat. II. Effect of caffeine on ACTH and cyclic nucleotide-induced steroidogenesis and its relation to cyclic nucleotide phosphodiesterase (PDE). Kitabchi AE, Wilson DB, Sharma RK. Biochem Biophys Res Commun. 1971 Aug 20;44(4):898–904. PubMed Europe PMC Scholia
  2. Inhibition of shear stress-induced platelet aggregation by cilostazol, a specific inhibitor of cGMP-inhibited phosphodiesterase, in vitro and ex vivo. Minami N, Suzuki Y, Yamamoto M, Kihira H, Imai E, Wada H, et al. Life Sci. 1997;61(25):PL 383-9. PubMed Europe PMC Scholia
  3. Isolation and characterization of cDNAs encoding PDE5A, a human cGMP-binding, cGMP-specific 3’,5’-cyclic nucleotide phosphodiesterase. Loughney K, Hill TR, Florio VA, Uher L, Rosman GJ, Wolda SL, et al. Gene. 1998 Aug 17;216(1):139–47. PubMed Europe PMC Scholia
  4. Sildenafil and cardiomyocyte-specific cGMP signaling prevent cardiomyopathic changes associated with dystrophin deficiency. Khairallah M, Khairallah RJ, Young ME, Allen BG, Gillis MA, Danialou G, et al. Proc Natl Acad Sci U S A. 2008 May 13;105(19):7028–33. PubMed Europe PMC Scholia
  5. Hippocampal Dopamine/DRD1 Signaling Dependent on the Ghrelin Receptor. Kern A, Mavrikaki M, Ullrich C, Albarran-Zeckler R, Brantley AF, Smith RG. Cell. 2015 Nov 19;163(5):1176–90. PubMed Europe PMC Scholia
  6. Phosphodiesterase Inhibition and Regulation of Dopaminergic Frontal and Striatal Functioning: Clinical Implications. Heckman PRA, van Duinen MA, Bollen EPP, Nishi A, Wennogle LP, Blokland A, et al. Int J Neuropsychopharmacol. 2016 Apr 2;19(10):pyw030. PubMed Europe PMC Scholia