Focal adhesion: PI3K-Akt-mTOR-signaling (WP3932)

Homo sapiens

Authors

Kristina Hanspers , Denise Slenter , Eric Weitz , and Marvin Martens

Activity

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Cited In

• Complete response to neoadjuvant chemoradiotherapy in rectal cancer is associated with RAS/AKT mutations and high tumour mutational burden (2021).
• Predictive models for stage and risk classification in head and neck squamous cell carcinoma (HNSCC) (2020).
• Biological Pathways Leading From ANGPTL8 to Diabetes Mellitus–A Co-expression Network Based Analysis (2018).
• Non-dialyzable uremic toxins and renal tubular cell damage in CKD patients: a systems biology approach (2024).

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Organisms

Homo sapiens

Communities

CPTAC ONTOX PancCanNet

Annotations

Pathway Ontology

mTOR signaling pathway cell adhesion signaling pathway signaling pathway

References

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3. Paxillin and focal adhesion signalling. Turner CE. Nat Cell Biol. 2000 Dec;2(12):E231-6. PubMed Europe PMC Scholia
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15. Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways. Lee JW, Juliano R. Mol Cells. 2004 Apr 30;17(2):188–202. PubMed Europe PMC Scholia
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17. Focal adhesion kinase: in command and control of cell motility. Mitra SK, Hanson DA, Schlaepfer DD. Nat Rev Mol Cell Biol. 2005 Jan;6(1):56–68. PubMed Europe PMC Scholia