Amino acid metabolism (WP3925)
Homo sapiens
A complete overview of the metabolism of all 20 amino acids. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP3925 CPTAC Assay Portal]
Authors
Kristina Hanspers , Egon Willighagen , and Eric WeitzActivity
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Cited In
- The m6A(m)-independent role of FTO in regulating WNT signaling pathways (2022).
- Assessing the Contribution of Relative Macrophage Frequencies to Subcutaneous Adipose Tissue (2021).
- Granule Cell Dispersion in Human Temporal Lobe Epilepsy: Proteomics Investigation of Neurodevelopmental Migratory Pathways (2020).
- Biological Pathways Leading From ANGPTL8 to Diabetes Mellitus–A Co-expression Network Based Analysis (2018).
- Human Monocytes Exposed to SARS-CoV-2 Display Features of Innate Immune Memory Producing High Levels of CXCL10 upon Restimulation (2023).
- Parallel use of human stem cell lung and heart models provide insights for SARS-CoV-2 treatment (2023).
Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.
Organisms
Homo sapiensCommunities
Annotations
Pathway Ontology
amino acid metabolic pathwayLabel | Type | Compact URI | Comment |
---|---|---|---|
Ethanol | Metabolite | hmdb:HMDB0000108 | |
Methionine | Metabolite | hmdb:HMDB0000696 | |
Indoleacetate | Metabolite | hmdb:HMDB0000197 | |
Aconitate | Metabolite | hmdb:HMDB0000072 | |
Oxaloacetate | Metabolite | hmdb:HMDB0000223 | |
Aspartate | Metabolite | hmdb:HMDB0000191 | |
Leucine | Metabolite | hmdb:HMDB0000687 | |
Urea | Metabolite | hmdb:HMDB0000294 | |
Fumarate | Metabolite | hmdb:HMDB0000134 | |
isocitrate | Metabolite | hmdb:HMDB0000193 | |
Citrate | Metabolite | hmdb:HMDB0000094 | |
methylhistamine | Metabolite | hmdb:HMDB0000898 | |
Dopamine | Metabolite | hmdb:HMDB0000073 | |
Cystathionine | Metabolite | hmdb:HMDB0000099 | |
Carbamoyl-aspartate | Metabolite | hmdb:HMDB0000828 | |
Histidine | Metabolite | hmdb:HMDB0000177 | |
Pyruvate | Metabolite | hmdb:HMDB0000243 | |
5-OH-Trp | Metabolite | hmdb:HMDB0000472 | |
B-OH-butyrate | Metabolite | hmdb:HMDB0000011 | |
Glutamine | Metabolite | hmdb:HMDB0000641 | |
Glucose | Metabolite | hmdb:HMDB0000122 | |
Creatine P | Metabolite | hmdb:HMDB0001511 | |
Threonine | Metabolite | hmdb:HMDB0000167 | |
Glycine | Metabolite | hmdb:HMDB0000123 | |
Isoleucine | Metabolite | hmdb:HMDB0000172 | |
Arginine | Metabolite | hmdb:HMDB0000517 | |
Histamine | Metabolite | hmdb:HMDB0000870 | |
Melanin | Metabolite | hmdb:HMDB0004068 | |
Tyrosine | Metabolite | hmdb:HMDB0000158 | |
Ornithine | Metabolite | hmdb:HMDB0000214 | |
hydroxy-proline | Metabolite | hmdb:HMDB0000725 | |
mercaptopyruvate | Metabolite | hmdb:HMDB0001368 | |
Alanine | Metabolite | hmdb:HMDB0000161 | |
Asparagine | Metabolite | hmdb:HMDB0000168 | |
Homocysteine | Metabolite | hmdb:HMDB0000742 | |
Tryptamine | Metabolite | hmdb:HMDB0000303 | |
carbamoyl-P | Metabolite | hmdb:HMDB0001096 | |
Succinyl-CoA | Metabolite | hmdb:HMDB0001022 | |
Citrulline | Metabolite | hmdb:HMDB0000904 | |
Cysteine | Metabolite | hmdb:HMDB0000574 | |
Thyroxine | Metabolite | hmdb:HMDB0000248 | |
Spermidine | Metabolite | hmdb:HMDB0001257 | |
oxo-isocaproate | Metabolite | chebi:17865 | |
Serine | Metabolite | hmdb:HMDB0000187 | |
Spermine | Metabolite | hmdb:HMDB0001256 | |
Tryptophan | Metabolite | hmdb:HMDB0000929 | |
Oxobutyrate | Metabolite | hmdb:HMDB0000005 | |
P-enolpyruvate | Metabolite | hmdb:HMDB0000263 | |
Guanidinoacetate P | Metabolite | hmdb:HMDB0003705 | |
Lactate | Metabolite | hmdb:HMDB0000190 | |
OH-indoleacetate | Metabolite | hmdb:HMDB0000763 | |
methylmalonyl-CoA | Metabolite | chebi:15465 | |
Guanidinoacetate | Metabolite | hmdb:HMDB0000128 | |
Succinate | Metabolite | hmdb:HMDB0000254 | |
valine | Metabolite | hmdb:HMDB0000883 | |
Phenylalanine | Metabolite | hmdb:HMDB0000159 | |
oxo-methyl-valerate | Metabolite | chebi:35146 | |
oxo-isovalerate | Metabolite | chebi:11851 | |
Putrescine | Metabolite | hmdb:HMDB0001414 | |
methylmalonate semialdehyde | Metabolite | chebi:16256 | |
Serotonin | Metabolite | hmdb:HMDB0000259 | |
Dihydro-orotate | Metabolite | hmdb:HMDB0003349 | |
Glutamate | Metabolite | hmdb:HMDB0000148 | |
Malate | Metabolite | hmdb:HMDB0000156 | |
Proline | Metabolite | hmdb:HMDB0000162 | |
Indoleacetaldehyde | Metabolite | hmdb:HMDB0001190 | |
HCO3 | Metabolite | hmdb:HMDB0003538 | |
NADP | Metabolite | hmdb:HMDB0000217 | |
Met-tRNA | Metabolite | chebi:16635 | |
Arginino-succinate | Metabolite | hmdb:HMDB0000052 | |
N-Formylkynurenine | Metabolite | hmdb:HMDB0001200 | |
Arg-tRNA | Metabolite | chebi:18366 | |
Ala-tRNA | Metabolite | chebi:17732 | |
Trp-tRNA | Metabolite | chebi:29159 | |
isobutyryl-CoA | Metabolite | chebi:15479 | |
Val-tRNA | Metabolite | chebi:29164 | |
Leu-tRNA | Metabolite | chebi:16624 | |
Ile-tRNA | Metabolite | chebi:29160 | |
Isovaleryl-CoA | Metabolite | hmdb:HMDB0001113 | |
Methylbutyryl-CoA | Metabolite | hmdb:HMDB0001041 | |
Acetyl-CoA | Metabolite | hmdb:HMDB0001206 | |
OH-methylglutaryl-CoA | Metabolite | hmdb:HMDB0001375 | |
methacrylyl-CoA | Metabolite | chebi:27754 | |
OH-isobutyrate | Metabolite | chebi:19641 | |
Tiglyl-CoA | Metabolite | hmdb:HMDB0002054 | |
OH-isovaleryl-CoA | Metabolite | hmdb:HMDB0006870 | |
Methylacetoacetyl-CoA | Metabolite | hmdb:HMDB0001157 | |
OH-isobutyryl-CoA | Metabolite | hmdb:HMDB0001052 | |
Methylcrotonyl-CoA | Metabolite | hmdb:HMDB0001493 | |
Methyl-OH-butyryl-CoA | Metabolite | hmdb:HMDB0001356 | |
Propionyl-CoA | Metabolite | hmdb:HMDB0001275 | |
Methylglutaconyl-CoA | Metabolite | hmdb:HMDB0001057 | |
His-tRNA | Metabolite | chebi:29155 | |
pyrroline carboxylate | Metabolite | hmdb:HMDB0006875 | |
Glu-tRNA | Metabolite | chebi:29157 | |
glutamate semialdehyde | Metabolite | chebi:15757 | |
glutamyl-P | Metabolite | chebi:21314 | |
Imidazole acetaldehyde | Metabolite | hmdb:HMDB0003905 | |
2-oxo-glutarate | Metabolite | chebi:16810 | |
glutamyl-cysteine | Metabolite | chebi:17515 | |
Red. Glutathione | Metabolite | hmdb:HMDB0000125 | |
R-S-glutathione | Metabolite | chebi:17021 | |
Ox. glutathione | Metabolite | hmdb:HMDB0003337 | |
Phe-tRNA | Metabolite | chebi:29153 | |
homogentisate | Metabolite | chebi:16169 | |
Epinephrine | Metabolite | hmdb:HMDB0000068 | |
Norepinephrine | Metabolite | hmdb:HMDB0000216 | |
Tyr-tRNA | Metabolite | chebi:29161 | |
GSR | GeneProduct | ensembl:ENSG00000104687 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:95804 |
HDC | GeneProduct | ensembl:ENSG00000140287 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:96062 |
CBS | GeneProduct | ensembl:ENSG00000160200 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:88285 |
SMS | GeneProduct | ensembl:ENSG00000102172 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:109490 |
MDH1 | GeneProduct | ensembl:ENSG00000014641 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:97051 |
PKM | GeneProduct | ensembl:ENSG00000067225 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:97591 |
ASS1 | GeneProduct | ensembl:ENSG00000130707 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:88090 |
AOC3 | GeneProduct | ensembl:ENSG00000131471 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1306797 |
EPRS | GeneProduct | ensembl:ENSG00000136628 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:97838 |
DLD | GeneProduct | ensembl:ENSG00000091140 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:107450 |
PCK1 | GeneProduct | ensembl:ENSG00000124253 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:97501 |
GLUD1 | GeneProduct | ensembl:ENSG00000148672 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:95753 |
HMGCS2 | GeneProduct | ensembl:ENSG00000134240 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:101939 |
HNMT | GeneProduct | ensembl:ENSG00000150540 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:2153181 |
DDC | GeneProduct | ensembl:ENSG00000132437 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:94876 |
ACADM | GeneProduct | ensembl:ENSG00000117054 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:87867 |
GOT2 | GeneProduct | ensembl:ENSG00000125166 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:95792 |
AUH | GeneProduct | ensembl:ENSG00000148090 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1338011 |
PDK4 | GeneProduct | ensembl:ENSG00000004799 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1351481 |
AC007325.2 | GeneProduct | ensembl:ENSG00000277196 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:19125 |
DLST | GeneProduct | ensembl:ENSG00000119689 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1926170 |
FAH | GeneProduct | ensembl:ENSG00000103876 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:95482 |
EHHADH | GeneProduct | ensembl:ENSG00000113790 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1277964 |
HAL | GeneProduct | ensembl:ENSG00000084110 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:96010 |
IARS | GeneProduct | ensembl:ENSG00000196305 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:2145219 |
ALDH1A1 | GeneProduct | ensembl:ENSG00000165092 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1353450 |
HIBCH | GeneProduct | ensembl:ENSG00000198130 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1923792 |
TAT | GeneProduct | ensembl:ENSG00000198650 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:98487 |
CAD | GeneProduct | ensembl:ENSG00000084774 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1916969 |
MARS2 | GeneProduct | ensembl:ENSG00000247626 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:2444136 |
BHMT | GeneProduct | ensembl:ENSG00000145692 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1339972 |
BCAT1 | GeneProduct | ensembl:ENSG00000060982 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:104861 |
ACAA1 | GeneProduct | ensembl:ENSG00000060971 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:2148491 |
HIBADH | GeneProduct | ensembl:ENSG00000106049 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1889802 |
GPT2 | GeneProduct | ensembl:ENSG00000166123 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1915391 |
P4HA2 | GeneProduct | ensembl:ENSG00000072682 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:894286 |
PDHA1 | GeneProduct | ensembl:ENSG00000131828 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = U:Mm.34775 |
TPO | GeneProduct | ensembl:ENSG00000115705 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:98813 |
GCLM | GeneProduct | ensembl:ENSG00000023909 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:104995 |
ADH5 | GeneProduct | ensembl:ENSG00000197894 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:87929 |
OAT | GeneProduct | ensembl:ENSG00000065154 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:97394 |
PPM1L | GeneProduct | ensembl:ENSG00000163590 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = U:Mm.40577 |
ADH4 | GeneProduct | ensembl:ENSG00000198099 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1349472 |
MAOA | GeneProduct | ensembl:ENSG00000189221 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:96915 |
TH | GeneProduct | ensembl:ENSG00000180176 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:98735 |
SDS | GeneProduct | ensembl:ENSG00000135094 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:98270 |
LARS2 | GeneProduct | ensembl:ENSG00000011376 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:2142973 |
G6PC2 | GeneProduct | ensembl:ENSG00000152254 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = U:Mm.140768 |
WARS | GeneProduct | ensembl:ENSG00000140105 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:104630 |
LDHA | GeneProduct | ensembl:ENSG00000134333 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:96759 |
ADH1C | GeneProduct | ensembl:ENSG00000248144 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:87921 |
GLS | GeneProduct | ensembl:ENSG00000115419 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:95752 |
SDHA | GeneProduct | ensembl:ENSG00000073578 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1914195 |
FARSB | GeneProduct | ensembl:ENSG00000116120 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1346035 |
ASNS | GeneProduct | ensembl:ENSG00000070669 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1350929 |
ALDH7A1 | GeneProduct | ensembl:ENSG00000164904 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:108186 |
MPST | GeneProduct | ensembl:ENSG00000128309 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:2179733 |
SUCLG1 | GeneProduct | ensembl:ENSG00000163541 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1927234 |
HMGCL | GeneProduct | ensembl:ENSG00000117305 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:96158 |
ADH7 | GeneProduct | ensembl:ENSG00000196344 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:87926 |
PC | GeneProduct | ensembl:ENSG00000173599 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:97520 |
PYCR1 | GeneProduct | ensembl:ENSG00000183010 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:2384795 |
OGDH | GeneProduct | ensembl:ENSG00000105953 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18293 |
AC068533.7 | GeneProduct | ensembl:ENSG00000249319 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:88084 |
GSS | GeneProduct | ensembl:ENSG00000100983 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:95852 |
FH | GeneProduct | ensembl:ENSG00000091483 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14194 |
CTH | GeneProduct | ensembl:ENSG00000116761 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1339968 |
TPH1 | GeneProduct | ensembl:ENSG00000129167 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:98796 |
MUT | GeneProduct | ensembl:ENSG00000146085 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:97239 |
ARG1 | GeneProduct | ensembl:ENSG00000118520 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:88070 |
MDH2 | GeneProduct | ensembl:ENSG00000146701 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:97050 |
IDH1 | GeneProduct | ensembl:ENSG00000138413 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:96413 |
PNMT | GeneProduct | ensembl:ENSG00000141744 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:97724 |
DBH | GeneProduct | ensembl:ENSG00000123454 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:94864 |
ACO2 | GeneProduct | ensembl:ENSG00000100412 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:87880 |
GLUL | GeneProduct | ensembl:ENSG00000135821 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:95739 |
RARS | GeneProduct | ensembl:ENSG00000113643 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1914297 |
MCCC1 | GeneProduct | ensembl:ENSG00000078070 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1919289 |
ODC1 | GeneProduct | ensembl:ENSG00000115758 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:97402 |
FTCD | GeneProduct | ensembl:ENSG00000160282 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1339962 |
ALDH18A1 | GeneProduct | ensembl:ENSG00000059573 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1888908 |
GOT1 | GeneProduct | ensembl:ENSG00000120053 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:95791 |
CS | GeneProduct | ensembl:ENSG00000062485 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:88529 |
ACLY | GeneProduct | ensembl:ENSG00000131473 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:103251 |
VARS | GeneProduct | ensembl:ENSG00000204394 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:90675 |
PDHX | GeneProduct | ensembl:ENSG00000110435 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1351627 |
TDO2 | GeneProduct | ensembl:ENSG00000151790 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1928486 |
OTC | GeneProduct | ensembl:ENSG00000036473 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:97448 |
AP002884.2 | GeneProduct | ensembl:ENSG00000255292 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1914175 |
ACSS1 | GeneProduct | ensembl:ENSG00000154930 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1915988 |
CPS1 | GeneProduct | ensembl:ENSG00000021826 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:891996 |
SRM | GeneProduct | ensembl:ENSG00000116649 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:102690 |
HADH | GeneProduct | ensembl:ENSG00000138796 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:96009 |
ARG2 | GeneProduct | ensembl:ENSG00000081181 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1330806 |