MYD88 distinct input-output pathway (WP3877)
Homo sapiens
This pathway is based on figure 7 from Li et al. Formation of MyD88 dimer catalyzes formation of IRAK1/TRAF6 complex. UEV1A and Ubc13 ubiquinate TRAF6 which allow for the activation of NFKB and AP-1 through canonical IKK phosphorylation. This complex also induces the production of reactive oxygen species. Proteins on this pathway have targeted assays available via the CPTAC Assay Portal.
For a description of pathway objects, see the WikiPathways Legend.
Authors
AAR&Co , Friederike Ehrhart , Kristina Hanspers , Eric Weitz , Alex Pico , and Egon WillighagenActivity
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Cited In
- Bioinformatics and systems-biology analysis to determine the effects of Coronavirus disease 2019 on patients with allergic asthma (2022).
- Decoding the transcriptome from bulk RNA of infection-naïve versus imprinted patients with SARS-CoV-2 Omicron B.1.1.529 (2025).
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Organisms
Homo sapiensCommunities
Annotations
Pathway Ontology
Toll-like receptor signaling pathway signaling pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| Reactive oxygen species | Metabolite | pubchem.compound:784 | |
| IRAK1 | GeneProduct | ensembl:ENSG00000184216 | |
| MYD88 | GeneProduct | ensembl:ENSG00000172936 | |
| TLR9 | GeneProduct | ensembl:ENSG00000239732 | |
| TLR6 | GeneProduct | ensembl:ENSG00000174130 | |
| TLR5 | GeneProduct | ensembl:ENSG00000187554 | |
| IL-1 | GeneProduct | ensembl:ENSG00000115008 | Interleukin Not Specified |
| TLR1 | GeneProduct | ensembl:ENSG00000174125 | |
| TRAF6 | GeneProduct | ensembl:ENSG00000175104 | |
| TLR4 | GeneProduct | ensembl:ENSG00000136869 | |
| TIFA | GeneProduct | ensembl:ENSG00000145365 | |
| TLR7 | GeneProduct | ensembl:ENSG00000196664 | |
| TLR2 | GeneProduct | ensembl:ENSG00000137462 | |
| TLR10 | GeneProduct | ensembl:ENSG00000174123 | |
| NFKB | GeneProduct | ensembl:ENSG00000109320 | NFKB NOt Specified |
| UEV1A | GeneProduct | ensembl:ENSG00000244687 | |
| UBC13 | GeneProduct | ensembl:ENSG00000177889 | |
| TLR8 | GeneProduct | ensembl:ENSG00000101916 | |
| AP-1 | Protein | uniprot:P05412 |
References
- Identification of potential pathway mediation targets in Toll-like receptor signaling. Li F, Thiele I, Jamshidi N, Palsson BØ. PLoS Comput Biol. 2009 Feb;5(2):e1000292. PubMed Europe PMC Scholia