Canonical and non-canonical TGF-B signaling (WP3874)
Homo sapiens
This pathway is modeled after Figure 9 in the article "Gremlin utilizes canonical and non-canonical TGFB signaling to induce lysyl oxidase (LOX) genes in human trabecular meshwork cells". Gremlin is enables the TGF-B signaling pathways to oversee LOX and LOXL proteins and also demonstrates that the non-canonical JNK1/2 complex, canonical SMAD, and P38 signaling pathways are involved in this pathway. TGF-B signaling is possible through Gremlin's ability to bock the BMP signaling pathway which inhibits TGF-B receptors. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP3874 CPTAC Assay Portal]
Authors
AAR&Co , Friederike Ehrhart , Kristina Hanspers , and Eric WeitzActivity
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Cited In
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Organisms
Homo sapiensCommunities
Annotations
Pathway Ontology
Bone morphogenetic proteins signaling pathwayDisease Ontology
primary angle-closure glaucomaCell Type Ontology
trabecular meshwork cellLabel | Type | Compact URI | Comment |
---|---|---|---|
SMAD4 | GeneProduct | ensembl:ENSG00000141646 | |
BMPR2 | GeneProduct | ensembl:ENSG00000204217 | |
MAPK14 | GeneProduct | ensembl:ENSG00000112062 | P38 |
SMAD3 | GeneProduct | ensembl:ENSG00000166949 | |
LOXL4 | GeneProduct | ensembl:ENSG00000138131 | |
BMP1 | GeneProduct | ensembl:ENSG00000168487 | BMP |
LOXL2 | GeneProduct | ensembl:ENSG00000134013 | |
LOXL1 | GeneProduct | ensembl:ENSG00000129038 | |
GREM1 | GeneProduct | ensembl:ENSG00000166923 | Grem |
LOX | GeneProduct | ensembl:ENSG00000113083 | |
JNK2 | GeneProduct | ensembl:ENSG00000050748 | |
JNK1 | GeneProduct | ensembl:ENSG00000107643 | |
TGFBR2 | GeneProduct | ensembl:ENSG00000163513 | |
SMAD2 | GeneProduct | ensembl:ENSG00000175387 | |
TGFBR1 | GeneProduct | ensembl:ENSG00000106799 | |
BMPR1 | GeneProduct | ensembl:ENSG00000107779 | |
TGFB1 | GeneProduct | ensembl:ENSG00000105329 | TGF-Beta |
References
- Gremlin utilizes canonical and non-canonical TGFβ signaling to induce lysyl oxidase (LOX) genes in human trabecular meshwork cells. Sethi A, Wordinger RJ, Clark AF. Exp Eye Res. 2013 Aug;113:117–27. PubMed Europe PMC Scholia