Apoptosis modulation by HSP70 (WP384)
Homo sapiens
This pathway summarizes the various ways by which HSP70 proteins can inhibit apoptosis. This pathway was originally adapted from rat. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP384 CPTAC Assay Portal]
Authors
Ismael Reyes , Kristina Hanspers , Paolo Romano , Jildau Bouwman , Alex Pico , Christine Chichester , Lora Simons , Egon Willighagen , and Eric WeitzActivity
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Cited In
- Investigating the Molecular Processes behind the Cell-Specific Toxicity Response to Titanium Dioxide Nanobelts (2021).
- Gene expression regulated by abatacept associated with methotrexate and correlation with disease activity in rheumatoid arthritis (2020).
- MicroRNAs as potential biomarkers for doxorubicin-induced cardiotoxicity.
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Organisms
Homo sapiensCommunities
Annotations
Pathway Ontology
apoptotic cell death pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| TNFRSF1A | GeneProduct | ncbigene:7132 | |
| CASP9 | GeneProduct | ncbigene:842 | |
| CASP8 | GeneProduct | ncbigene:841 | |
| CASP2 | GeneProduct | ncbigene:835 | |
| FADD | GeneProduct | ncbigene:8772 | |
| MAP3K1 | GeneProduct | ncbigene:4214 | |
| RIPK1 | GeneProduct | ncbigene:8737 | |
| FAS | GeneProduct | ncbigene:355 | |
| CASP3 | GeneProduct | ncbigene:836 | |
| NFKB1 | GeneProduct | ncbigene:4790 | |
| CYCS | GeneProduct | ncbigene:54205 | |
| HSPA1A | GeneProduct | ncbigene:3303 | |
| CASP6 | GeneProduct | ncbigene:839 | |
| APAF1 | GeneProduct | ncbigene:317 | |
| MAPK10 | GeneProduct | ncbigene:5602 | |
| FAS-Ligand | GeneProduct | ensembl:ENSG00000117560 | |
| BID | GeneProduct | ncbigene:637 | |
| CASP7 | GeneProduct | ncbigene:840 | |
| PDCD8 | GeneProduct | ncbigene:9131 | Apoptosis Inducing Factor |
| TNF | GeneProduct | ensembl:ENSG00000204490 |
References
- Hsp70 exerts its anti-apoptotic function downstream of caspase-3-like proteases. Jäättelä M, Wissing D, Kokholm K, Kallunki T, Egeblad M. EMBO J. 1998 Nov 2;17(21):6124–34. PubMed Europe PMC Scholia
- Role of Hsp70 in regulation of stress-kinase JNK: implications in apoptosis and aging. Gabai VL, Meriin AB, Yaglom JA, Volloch VZ, Sherman MY. FEBS Lett. 1998 Oct 30;438(1–2):1–4. PubMed Europe PMC Scholia
- Activation of Fas inhibits heat-induced activation of HSF1 and up-regulation of hsp70. Schett G, Steiner CW, Gröger M, Winkler S, Graninger W, Smolen J, et al. FASEB J. 1999 May;13(8):833–42. PubMed Europe PMC Scholia
- Negative regulation of the Apaf-1 apoptosome by Hsp70. Saleh A, Srinivasula SM, Balkir L, Robbins PD, Alnemri ES. Nat Cell Biol. 2000 Aug;2(8):476–83. PubMed Europe PMC Scholia
- The chaperone function of hsp70 is required for protection against stress-induced apoptosis. Mosser DD, Caron AW, Bourget L, Meriin AB, Sherman MY, Morimoto RI, et al. Mol Cell Biol. 2000 Oct;20(19):7146–59. PubMed Europe PMC Scholia
- HSP27 and HSP70: potentially oncogenic apoptosis inhibitors. Garrido C, Schmitt E, Candé C, Vahsen N, Parcellier A, Kroemer G. Cell Cycle. 2003;2(6):579–84. PubMed Europe PMC Scholia
- Heat shock protein 70 binding inhibits the nuclear import of apoptosis-inducing factor. Gurbuxani S, Schmitt E, Cande C, Parcellier A, Hammann A, Daugas E, et al. Oncogene. 2003 Oct 2;22(43):6669–78. PubMed Europe PMC Scholia
- The life span determinant p66Shc localizes to mitochondria where it associates with mitochondrial heat shock protein 70 and regulates trans-membrane potential. Orsini F, Migliaccio E, Moroni M, Contursi C, Raker VA, Piccini D, et al. J Biol Chem. 2004 Jun 11;279(24):25689–95. PubMed Europe PMC Scholia