Renin-angiotensin system (WP376)
Rattus norvegicus
This pathway is based on the [http://www.genome.jp/dbget-bin/show_pathway?map04614+C15850 KEGG pathway] of renin-angiotensin and the [http://www.ambion.com/tools/pathway/pathway.php?pathway=Renin-Angiotensin%20Pathway Ambion pathway] of renin-angiotensin
Authors
Rishi , Mark Van Grinsven , Thomas Kelder , Chris Evelo , Daniela Digles , Martina Summer-Kutmon , Agustin Gonzalez-Vicente , Egon Willighagen , Denise Slenter , Kristina Hanspers , and Eric WeitzActivity
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Cited In
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Organisms
Rattus norvegicusCommunities
Renal Genomics PathwaysAnnotations
Disease Ontology
renal hypertension hypertensionPathway Ontology
renin-angiotensin cascade pathwayLabel | Type | Compact URI | Comment |
---|---|---|---|
Angiotensin 1 | Metabolite | hmdb:HMDB0061196 | |
PIP2 | Metabolite | chebi:18348 | |
Angiotensin III | Metabolite | hmdb:HMDB0001036 | |
ROS | Metabolite | chebi:26523 | |
CA2+ | Metabolite | hmdb:HMDB0000464 | |
IP3 | Metabolite | hmdb:HMDB0001143 | |
cAMP | Metabolite | hmdb:HMDB0000058 | |
Ceramide | Metabolite | chebi:17761 | |
DAG | Metabolite | chebi:18035 | |
Angiotensin (1-5) | Metabolite | chebi:80129 | |
Angiotensin IV | Metabolite | hmdb:HMDB0001038 | |
Angiotensin (1-9) | Metabolite | chebi:80128 | |
Angiotensin II | Metabolite | hmdb:HMDB0001035 | |
Angiotensin (1-7) | Metabolite | pubchem.compound:123805 | |
NO | Metabolite | hmdb:HMDB0003378 | |
Fos | GeneProduct | ensembl:ENSRNOG00000008015 | |
Ace | Protein | rgd:2493 | |
IP3R | Protein | interpro:IPR000493 | |
Ikbkg | Protein | ensembl:ENSRNOG00000060936 | |
Itpr3 | Protein | rgd:2934 | |
c-Jun | Protein | rgd:2943 | |
PAK2 | Protein | rgd:61953 | |
Itpr1 | Protein | rgd:2933 | |
Ppgb | Protein | rgd:1309070 | |
TYK | Protein | ensembl:ENSRNOG00000032948 | |
Mme | Protein | rgd:3098 | |
ERK1 | Protein | rgd:70500 | |
Itpr2 | Protein | rgd:69649 | |
Grb2 | Protein | ncbigene:81504 | |
MEKK1 | Protein | rgd:620966 | |
Enpep | Protein | rgd:621228 | |
PPtase | Protein | rgd:62018 | |
Prkcq | Protein | rgd:620968 | |
Mapk10 | Protein | rgd:3663 | |
PAK7 | Protein | rgd:1312009 | |
Mapk9 | Protein | rgd:628847 | |
AC2/3 | Protein | rgd:2036 | |
Ikbkb | Protein | rgd:621375 | |
FAK | Protein | rgd:3443 | |
PAK4 | Protein | rgd:1307705 | |
Mapk3 | Protein | ensembl:ENSRNOG00000053583 | |
CTSG | Protein | rgd:1307681 | |
Ras | Protein | rgd:2981 | |
Thop1 | Protein | rgd:68330 | |
Mas1 | Protein | rgd:3049 | |
Anpep | Protein | rgd:2991 | |
ATF2 | Protein | ncbigene:81647 | |
TYK | Protein | ensembl:ENSRNOG00000032948 | Assuming this protein stands for TYK2 (it seems TYK1 is not related to this interaction). |
Jak2 | Protein | ensembl:ENSRNOG00000059968 | |
NF-KB | Protein | rgd:727889 | |
PAK | Protein | eccode:2.7.11.1 | Cannot find a more specific identifier in this context, see https://en.wikipedia.org/wiki/Serine/threonine-specific_protein_kinase as a start. |
STAT3 | Protein | rgd:3772 | |
Plcb1 | Protein | rgd:3344 | |
Cpa3 | Protein | rgd:2390 | |
PAK6 | Protein | rgd:1306213 | |
Mapk8 | Protein | rgd:621506 | |
Lnpep | Protein | rgd:621752 | |
Rac1 | Protein | rgd:619755 | |
STAT1 | Protein | rgd:3771 | |
Ace2 | Protein | rgd:728890 | |
PtgIR | Protein | ncbigene:292661 | |
PYK2 | Protein | rgd:628758 | |
Nln | Protein | rgd:621518 | |
GalfaQ/11 | Protein | uniprot:Q9JID2 | |
Angiotensinogen | Protein | rgd:2069 | |
Agtr2 | Protein | rgd:2072 | |
CMA1 | Protein | rgd:2365 | |
Raf1 | Protein | ncbigene:24703 | |
PKA | Protein | rgd:3389 | |
PAK3 | Protein | rgd:3251 | |
Agtr1a | Protein | rgd:2070 | |
p38 | Protein | rgd:3045 | |
SHC | Protein | ensembl:ENSRNOG00000020657 | Mapping based on name of ortholog human gene. |
JNK | Protein | ensembl:ENSRNOG00000020155 | |
MKK4 | Protein | rgd:1307040 | |
Renin | Protein | rgd:3554 | |
PAK1 | Protein | rgd:3250 | |
MKK7 | Protein | rgd:1560043 | |
SOS | Protein | interpro:IPR023578 | Unclear which ortholog is meant, see also: https://en.wikipedia.org/wiki/Son_of_Sevenless |
Elk1 | Protein | rgd:1598663 | |
PI3K | Protein | ensembl:ENSRNOG00000056371 | Identifier based on similar name for ortholog human gene |
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