Hepatitis C and hepatocellular carcinoma (WP3646)
Homo sapiens
Pathway model based on hub miRNAs and their putative targets from network analysis. * From a set of differentially expressed genes in both chronic HCV (hepatitis C virus) and HCC (hepatocellular carcinoma) samples, a protein-protein network was constructed using STRING and GeneMANIA. * After topological analysis and network visualization in Cytoscape, the top hub genes were identified. * miRNAs related to hub genes were identified using miRTarBase server and combined with the PPI network to constructed a miRNA-Hubgene network. Based on Figure 4 from Poortahmasebi et al, How Hepatitis C Virus Leads to Hepatocellular Carcinoma: A Network-Based Study. Proteins on this pathway have targeted assays available via the CPTAC Assay Portal.
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Authors
Kristina Hanspers , Jonathan Mélius , Andika Tan , Martina Summer-Kutmon , Egon Willighagen , and Eric WeitzActivity
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Cited In
- Target and drug predictions for SARS-CoV-2 infection in hepatocellular carcinoma patients (2022).
- The Biological Interaction of SARS-CoV-2 Infection and Osteoporosis: A Preliminary Study (2022).
- IL6-mediated HCoV-host interactome regulatory network and GO/Pathway enrichment analysis (2020).
- GediNET for discovering gene associations across diseases using knowledge based machine learning approach (2022).
- Exploring the pharmacological mechanism of Duhuo Jisheng Decoction in treating intervertebral disc degeneration based on network pharmacology (2023).
- Differential Protein-Coding Gene Expression Profile in Patients with Prostate Cancer (2024).
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Organisms
Homo sapiensCommunities
CPTAC Diseases ExRNAAnnotations
Disease Ontology
hepatocellular carcinomaPathway Ontology
disease pathwayReferences
- How Hepatitis C Virus Leads to Hepatocellular Carcinoma: A Network-Based Study. Poortahmasebi V, Poorebrahim M, Najafi S, Jazayeri SM, Alavian SM, Arab SS, et al. Hepat Mon. 2016 Feb 20;16(2):e36005. PubMed Europe PMC Scholia