Hepatitis C and hepatocellular carcinoma (WP3646)

Homo sapiens

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Pathway model based on hub miRNAs and their putative targets from network analysis. * From a set of differentially expressed genes in both chronic HCV (hepatitis C virus) and HCC (hepatocellular carcinoma) samples, a protein-protein network was constructed using STRING and GeneMANIA. * After topological analysis and network visualization in Cytoscape, the top hub genes were identified. * miRNAs related to hub genes were identified using miRTarBase server and combined with the PPI network to constructed a miRNA-Hubgene network. Based on Figure 4 from Poortahmasebi et al, How Hepatitis C Virus Leads to Hepatocellular Carcinoma: A Network-Based Study. Proteins on this pathway have targeted assays available via the CPTAC Assay Portal.

For a description of pathway objects, see the WikiPathways Legend.

Authors

Kristina Hanspers , Jonathan Mélius , Andika Tan , Martina Summer-Kutmon , Egon Willighagen , and Eric Weitz

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

CPTAC Diseases ExRNA

Annotations

Disease Ontology

hepatocellular carcinoma

Pathway Ontology

disease pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
BIRC3 GeneProduct ensembl:ENSG00000023445
MAPK14 GeneProduct ensembl:ENSG00000112062
RRM2 GeneProduct ensembl:ENSG00000171848
VEGFA GeneProduct ensembl:ENSG00000112715
FASLG GeneProduct ensembl:ENSG00000117560
COL4A2 GeneProduct ensembl:ENSG00000134871
RAC1 GeneProduct ensembl:ENSG00000136238
BCL2L1 GeneProduct ensembl:ENSG00000171552
CXCR1 GeneProduct ensembl:ENSG00000163464
BIRC5 GeneProduct ensembl:ENSG00000089685
MIR34A GeneProduct ensembl:ENSG00000284357
VAV2 GeneProduct ensembl:ENSG00000160293
STAT3 GeneProduct ensembl:ENSG00000168610
PODXL GeneProduct ensembl:ENSG00000128567
PTPN11 GeneProduct ensembl:ENSG00000179295
UCHL1 GeneProduct ensembl:ENSG00000154277
MAPK3 GeneProduct ensembl:ENSG00000102882
CCND1 GeneProduct ensembl:ENSG00000110092
FRZB GeneProduct ensembl:ENSG00000162998
TP53 GeneProduct ensembl:ENSG00000141510
JAK1 GeneProduct ensembl:ENSG00000162434
IL8 GeneProduct ensembl:ENSG00000169429
MMP1 GeneProduct ensembl:ENSG00000196611
MIR744 GeneProduct ensembl:ENSG00000266297
NFKB1 GeneProduct ensembl:ENSG00000109320
AKT1 GeneProduct ensembl:ENSG00000142208
MYOF GeneProduct ensembl:ENSG00000138119
IL6R GeneProduct ensembl:ENSG00000160712
LEF1 GeneProduct ensembl:ENSG00000138795
BRCA1 GeneProduct ensembl:ENSG00000012048
CD44 GeneProduct ensembl:ENSG00000026508
IL6 GeneProduct ensembl:ENSG00000136244
SOS1 GeneProduct ensembl:ENSG00000115904
CASP9 GeneProduct ensembl:ENSG00000132906
TGFB1 GeneProduct ensembl:ENSG00000105329
CTTN GeneProduct ensembl:ENSG00000085733
SMAD3 GeneProduct ensembl:ENSG00000166949
PTGS2 GeneProduct ensembl:ENSG00000073756
E2F2 GeneProduct ensembl:ENSG00000007968
GRB2 GeneProduct ensembl:ENSG00000177885
HIF1A GeneProduct ensembl:ENSG00000100644
MYC GeneProduct ensembl:ENSG00000136997
CASP3 GeneProduct ensembl:ENSG00000164305
CDKN1A GeneProduct ensembl:ENSG00000124762
HNF1A GeneProduct ensembl:ENSG00000135100
JUN GeneProduct ensembl:ENSG00000177606
CASP7 GeneProduct ensembl:ENSG00000165806
MIR155 GeneProduct ensembl:ENSG00000283904
MIR24-1 GeneProduct ensembl:ENSG00000284459
MIR24-2 GeneProduct ensembl:ENSG00000284387
MIR92A1 GeneProduct hgnc.symbol:MIR92A1
MIR92A2 GeneProduct ensembl:ENSG00000284538
NOS2 GeneProduct ensembl:ENSG00000007171
MAPK8 GeneProduct ensembl:ENSG00000107643
SMAD4 GeneProduct ensembl:ENSG00000141646
TGFBR1 GeneProduct ensembl:ENSG00000106799
TNFSS10 GeneProduct ensembl:ENSG00000117560

References

  1. How Hepatitis C Virus Leads to Hepatocellular Carcinoma: A Network-Based Study. Poortahmasebi V, Poorebrahim M, Najafi S, Jazayeri SM, Alavian SM, Arab SS, et al. Hepat Mon. 2016 Feb 20;16(2):e36005. PubMed Europe PMC Scholia