Photodynamic therapy-induced NF-kB survival signaling (WP3617)

Homo sapiens

Photodynamic therapy may induce a pro-inflammatory and angiogenic response mediated by NF-κB. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP3617 CPTAC Assay Portal]

Authors

Ruud Weijer , Kristina Hanspers , Alex Pico , Friederike Ehrhart , and Eric Weitz

Activity

last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.

Organisms

Homo sapiens

Communities

CPTAC

Annotations

Disease Ontology

cancer

Pathway Ontology

altered regulatory pathway

Participants

Label Type Compact URI Comment
ROS Metabolite chebi:26523
CSF2 GeneProduct ncbigene:1437
IL8 GeneProduct ncbigene:3576
IL6 GeneProduct ncbigene:3569
IL1B GeneProduct ncbigene:3553
IL1A GeneProduct ncbigene:3552
IL2 GeneProduct ncbigene:3558
VEGFA GeneProduct ncbigene:7422
CCND1 GeneProduct ncbigene:595
TNF GeneProduct ncbigene:7124
EGLN2 GeneProduct ncbigene:112398
IKBKB GeneProduct ncbigene:3551
CHUK GeneProduct ncbigene:1147
NFKB1 GeneProduct ncbigene:4790
RELA GeneProduct ncbigene:5970
REL GeneProduct ncbigene:5966
NFKB2 GeneProduct ncbigene:4791
TRAF6 GeneProduct ncbigene:7189
PTGS2 GeneProduct ncbigene:5743
ICAM1 GeneProduct ncbigene:3383
VCAM1 GeneProduct ncbigene:7412
CXCL2 GeneProduct ncbigene:2920
CD40LG GeneProduct ncbigene:959
SELE GeneProduct ncbigene:6401
TNFRSF1A GeneProduct ncbigene:7132
RELB GeneProduct ncbigene:5971
CFLAR GeneProduct ncbigene:8837
BIRC2 GeneProduct ncbigene:329
BIRC5 GeneProduct ncbigene:332
BIRC3 GeneProduct ncbigene:330
BCL2A1 GeneProduct ncbigene:597
BCL2L2 GeneProduct ncbigene:599
MMP3 GeneProduct ncbigene:4314
MMP9 GeneProduct ncbigene:4318
MMP2 GeneProduct ncbigene:4313
MMP1 GeneProduct ncbigene:4312

References

  1. Tumor cell survival pathways activated by photodynamic therapy: a molecular basis for pharmacological inhibition strategies. Broekgaarden M, Weijer R, van Gulik TM, Hamblin MR, Heger M. Cancer Metastasis Rev. 2015 Dec;34(4):643–90. PubMed Europe PMC Scholia
  2. Low-power photodynamic therapy induces survival signaling in perihilar cholangiocarcinoma cells. Weijer R, Broekgaarden M, van Golen RF, Bulle E, Nieuwenhuis E, Jongejan A, et al. BMC Cancer. 2015 Dec 26;15:1014. PubMed Europe PMC Scholia