MFAP5-mediated ovarian cancer cell motility and invasiveness (WP3301)
Homo sapiens
A graphical summary of the molecular signaling events involved in MFAP5-mediated ovarian cancer cell motility and invasiveness. Based on figure 6c in [https://www.ncbi.nlm.nih.gov/pubmed/25277212 Leung et al]. Phosphorylation sites were added based on information from PhosphoSitePlus (R), www.phosphosite.org. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP3301 CPTAC Assay Portal]
Authors
Kristina Hanspers , Elisa Cirillo , Andika Tan , and Friederike EhrhartActivity
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Cited In
- Target and drug predictions for SARS-CoV-2 infection in hepatocellular carcinoma patients (2022).
- Identification of candidate genes and pathways in retinopathy of prematurity by whole exome sequencing of preterm infants enriched in phenotypic extremes (2021).
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Organisms
Homo sapiensCommunities
CPTAC ExRNAAnnotations
Pathway Ontology
disease pathway cancer pathwayDisease Ontology
ovarian cancer disease of cellular proliferation| Label | Type | Compact URI | Comment |
|---|---|---|---|
| Ca2+ | Metabolite | hmdb:HMDB0000464 | |
| IP3 | Metabolite | cas:85166-31-0 | |
| DAG | Metabolite | hmdb:HMDB0007098 | |
| PIP2 | Metabolite | cas:245126-95-8 | |
| Troponin C | GeneProduct | ensembl:ENSG00000114854 | |
| CREB1 | GeneProduct | ensembl:ENSG00000118260 | |
| MFAP5 | GeneProduct | ensembl:ENSG00000197614 | |
| ITGB3 | GeneProduct | ensembl:ENSG00000259207 | |
| TNNC1 | GeneProduct | ensembl:ENSG00000114854 | |
| RYR3 | GeneProduct | ensembl:ENSG00000198838 | |
| PLCG1 | GeneProduct | ensembl:ENSG00000124181 | |
| FAK | GeneProduct | ensembl:ENSG00000169398 | |
| PRKCQ | GeneProduct | ensembl:ENSG00000065675 | |
| ITPR3 | GeneProduct | ensembl:ENSG00000096433 | |
| JUN | GeneProduct | ensembl:ENSG00000177606 | |
| ITGAV | GeneProduct | ensembl:ENSG00000138448 | |
| ERK2 | GeneProduct | ensembl:ENSG00000100030 | |
| ERK1 | GeneProduct | ensembl:ENSG00000102882 |
References
- Calcium-dependent FAK/CREB/TNNC1 signalling mediates the effect of stromal MFAP5 on ovarian cancer metastatic potential. Leung CS, Yeung TL, Yip KP, Pradeep S, Balasubramanian L, Liu J, et al. Nat Commun. 2014 Oct 3;5:5092. PubMed Europe PMC Scholia
- PhosphoSitePlus, 2014: mutations, PTMs and recalibrations. Hornbeck PV, Zhang B, Murray B, Kornhauser JM, Latham V, Skrzypek E. Nucleic Acids Res. 2015 Jan;43(Database issue):D512-20. PubMed Europe PMC Scholia