Nod-like receptor (NLR) signaling (WP288)

Homo sapiens

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Mammalian cells have evolved a set of specialized pattern recognition-molecules (PRMs) to detect conserved molecular motifs present on pathogens known as pathogen associated-molecular-patterns (PAMPs). NLR proteins (alternatively named NBD-LRR or CATERPILLER) represent one subclass of PRMs that have recently attracted much attention. Their cytoplasmic location differs from the classical PRMs which are mostly membrane spanning receptors (such as the Toll-like-receptors (TLRs) or lectins) and accordingly NLRs were proposed to be activated mainly by intracellular bacterial pathogens.

Authors

Kufer , Neerincx a , Thomas Kelder , Kristina Hanspers , Allan Kuchinsky , Daniela Digles , Alex Pico , Zahra Roudbari , Eric Weitz , Martina Summer-Kutmon , and Egon Willighagen

Activity

last edited

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

NOD-like receptor signaling pathway NOD-like receptor signaling pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
ERBB2IP GeneProduct ncbigene:55914
IKKalpha GeneProduct ncbigene:1147
NEMO GeneProduct ncbigene:8517
RelA GeneProduct ncbigene:5970
JNK GeneProduct ncbigene:5599
ERK GeneProduct ncbigene:2048
TAK1 GeneProduct ncbigene:6885
IKKbeta GeneProduct ncbigene:3551
p50 GeneProduct ncbigene:958

References

  1. Intracellular pattern recognition receptors in the host response. Meylan E, Tschopp J, Karin M. Nature. 2006 Jul 6;442(7098):39–44. PubMed Europe PMC Scholia
  2. Nod-like proteins in immunity, inflammation and disease. Fritz JH, Ferrero RL, Philpott DJ, Girardin SE. Nat Immunol. 2006 Dec;7(12):1250–7. PubMed Europe PMC Scholia
  3. Inflammasome adaptors and sensors: intracellular regulators of infection and inflammation. Mariathasan S, Monack DM. Nat Rev Immunol. 2007 Jan;7(1):31–40. PubMed Europe PMC Scholia
  4. Nod-like proteins in inflammation and disease. Carneiro LAM, Magalhaes JG, Tattoli I, Philpott DJ, Travassos LH. J Pathol. 2008 Jan;214(2):136–48. PubMed Europe PMC Scholia
  5. Signal transduction pathways used by NLR-type innate immune receptors. Kufer TA. Mol Biosyst. 2008 May;4(5):380–6. PubMed Europe PMC Scholia
  6. NOD-like receptors (NLRs): bona fide intracellular microbial sensors. Shaw MH, Reimer T, Kim YG, Nuñez G. Curr Opin Immunol. 2008 Aug;20(4):377–82. PubMed Europe PMC Scholia