S1P receptor signal transduction (WP26)
Homo sapiens
Metabolism of sphingomyelin by the sphingomyelinase, ceramidase (Cer'ase) and the sphingosine kinase (SK) enzymes results in formation of S1P and receptor activation. Autocrine and paracrine modes of receptor activation have been implied but have yet to be rigorously proven. Critical signaling molecules, such as phospholipase C (PLC), ERK, PI3K, and Akt are activated. Active Akt binds to the receptor and phosphorylates the third intracellular loop, which is essential for Rac activation. Representation of Figure 2. from T. Hla, et al. 2001, Science, 294, pg. 1877. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP26 CPTAC Assay Portal]
Authors
Scott Doniger , Thomas Kelder , Martijn Van Iersel , Kristina Hanspers , Alex Pico , Daniela Digles , Zahra Roudbari , Eric Weitz , Denise Slenter , and Egon WillighagenActivity
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Cited In
- Long Term Culture of the A549 Cancer Cell Line Promotes Multilamellar Body Formation and Differentiation towards an Alveolar Type II Pneumocyte Phenotype (2016).
- Reconstructed Human Skin with Hypodermis Shows Essential Role of Adipose Tissue in Skin Metabolism (2024).
- Integrative epigenetic profiling analysis identifies DNA methylation changes associated with chronic alcohol consumption (2015).
- A Practical Strategy for Exploring the Pharmacological Mechanism of Luteolin Against COVID-19/Asthma Comorbidity: Findings of System Pharmacology and Bioinformatics Analysis (2024).
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Organisms
Homo sapiensCommunities
Annotations
Pathway Ontology
G protein mediated signaling pathway sphingosine 1-phosphate signaling pathway signaling pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| PLCB2 | GeneProduct | ncbigene:5330 | |
| MAPK1 | GeneProduct | ncbigene:5594 | |
| GNAI3 | GeneProduct | ncbigene:2773 | |
| EDG8 | GeneProduct | ncbigene:53637 | |
| SMPD2 | GeneProduct | ncbigene:6610 | |
| ASAH1 | GeneProduct | ncbigene:427 | |
| SPHK2 | GeneProduct | ncbigene:56848 | |
| AKT1 | GeneProduct | ncbigene:207 | |
| MAPK7 | GeneProduct | ncbigene:5598 | |
| MAPK3 | GeneProduct | ncbigene:5595 | |
| EDG5 | GeneProduct | ncbigene:9294 | |
| SPHK1 | GeneProduct | ncbigene:8877 | |
| S1PR1 | GeneProduct | ncbigene:1901 | |
| GNAI2 | GeneProduct | ncbigene:2771 | |
| MAPK6 | GeneProduct | ncbigene:5597 | |
| PIK3C2B | GeneProduct | ncbigene:5287 | |
| PLCB1 | GeneProduct | ncbigene:23236 | |
| RACGAP1 | GeneProduct | ncbigene:29127 | |
| MAPK4 | GeneProduct | ncbigene:5596 | |
| PLCB3 | GeneProduct | ncbigene:5331 | |
| EDG3 | GeneProduct | ncbigene:1903 | |
| GNAI1 | GeneProduct | ncbigene:2770 | |
| MAPK12 | GeneProduct | ncbigene:6300 | |
| AKT3 | GeneProduct | ncbigene:10000 | |
| AKT2 | GeneProduct | ncbigene:208 |
References
- Lysophospholipids--receptor revelations. Hla T, Lee MJ, Ancellin N, Paik JH, Kluk MJ. Science. 2001 Nov 30;294(5548):1875–8. PubMed Europe PMC Scholia