Nanomaterial induced apoptosis (WP2507)
Homo sapiens
Apotosis caused by nanomaterials, such as single-walled carbon nanohorns, titanium oxide, and polystyrene nanoparticles, may be induced through lysosomal impairment. For example, PAMAMs have been found to cause mitochondrial membrane destabilization, and silver and gold nanoparticles are reported to induce ER stress, which may lead to cytochrome c release from mitochondria. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP2507 CPTAC Assay Portal]
Authors
Egon Willighagen , Anwesha Bohler , Bart Smeets , Friederike Ehrhart , Martina Summer-Kutmon , Fernando Torres Andón , Denise Slenter , Kristina Hanspers , Marvin Martens , and Finterly HuActivity
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Cited In
- Construction and analysis of protein-protein interaction network of non-alcoholic fatty liver disease.
- Autistic spectrum disorder (ASD) - Gene, molecular and pathway signatures linking systemic inflammation, mitochondrial dysfunction, transsynaptic signalling, and neurodevelopmen (2023).
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Organisms
Homo sapiensCommunities
Adverse Outcome Pathways Nanomaterials PathwaysAnnotations
Pathway Ontology
apoptotic cell death pathway nanomaterial response pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| TiO2 NP | Metabolite | None | |
| Au NP | Metabolite | None | |
| Polystyrene NP | Metabolite | chebi:134403 | |
| Nanohorn | Metabolite | None | |
| DNA | Metabolite | chebi:16991 | |
| Ca2+ | Metabolite | pubchem.compound:271 | |
| PAMAM | Metabolite | None | |
| Ag NP | Metabolite | None | |
| BCL2 | GeneProduct | ensembl:ENSG00000171791 | |
| FADD | GeneProduct | ensembl:ENSG00000168040 | |
| CASP8 | GeneProduct | ensembl:ENSG00000064012 | |
| AIF | GeneProduct | ensembl:ENSG00000156709 | |
| SMAC/DIABLO | GeneProduct | ensembl:ENSG00000184047 | |
| CASP7 | GeneProduct | ensembl:ENSG00000165806 | |
| BAK | GeneProduct | ensembl:ENSG00000030110 | |
| FASLG | GeneProduct | ensembl:ENSG00000117560 | |
| CASP9 | GeneProduct | ensembl:ENSG00000132906 | |
| FLIP | GeneProduct | ensembl:ENSG00000003402 | |
| FAS | GeneProduct | ensembl:ENSG00000026103 | |
| tBID | GeneProduct | ensembl:ENSG00000015475 | |
| Cyt C | GeneProduct | ensembl:ENSG00000172115 | |
| APAF-1 | GeneProduct | ensembl:ENSG00000120868 | |
| CASP6 | GeneProduct | ensembl:ENSG00000138794 | |
| CASP3 | GeneProduct | ensembl:ENSG00000164305 | |
| BAX | GeneProduct | ensembl:ENSG00000087088 | |
| Perforin | GeneProduct | ensembl:ENSG00000180644 | |
| EndoG | GeneProduct | ensembl:ENSG00000167136 | |
| HTRA2/OMI | GeneProduct | ensembl:ENSG00000115317 |
References
- Cationic polystyrene nanosphere toxicity depends on cell-specific endocytic and mitochondrial injury pathways. Xia T, Kovochich M, Liong M, Zink JI, Nel AE. ACS Nano. 2008 Jan;2(1):85–96. PubMed Europe PMC Scholia
- Nanosized polyamidoamine (PAMAM) dendrimer-induced apoptosis mediated by mitochondrial dysfunction. Lee JH, Cha KE, Kim MS, Hong HW, Chung DJ, Ryu G, et al. Toxicol Lett. 2009 Oct 28;190(2):202–7. PubMed Europe PMC Scholia
- Carbon black and titanium dioxide nanoparticles elicit distinct apoptotic pathways in bronchial epithelial cells. Hussain S, Thomassen LCJ, Ferecatu I, Borot MC, Andreau K, Martens JA, et al. Part Fibre Toxicol. 2010 Apr 16;7:10. PubMed Europe PMC Scholia
- Endoplasmic reticulum stress signaling is involved in silver nanoparticles-induced apoptosis. Zhang R, Piao MJ, Kim KC, Kim AD, Choi JY, Choi J, et al. Int J Biochem Cell Biol. 2012 Jan;44(1):224–32. PubMed Europe PMC Scholia
- Identification of the nanogold particle-induced endoplasmic reticulum stress by omic techniques and systems biology analysis. Tsai YY, Huang YH, Chao YL, Hu KY, Chin LT, Chou SH, et al. ACS Nano. 2011 Dec 27;5(12):9354–69. PubMed Europe PMC Scholia
- Lysosomal membrane destabilization induced by high accumulation of single-walled carbon nanohorns in murine macrophage RAW 264.7. Tahara Y, Nakamura M, Yang M, Zhang M, Iijima S, Yudasaka M. Biomaterials. 2012 Mar;33(9):2762–9. PubMed Europe PMC Scholia
- Programmed cell death: molecular mechanisms and implications for safety assessment of nanomaterials. Andón FT, Fadeel B. Acc Chem Res. 2013 Mar 19;46(3):733–42. PubMed Europe PMC Scholia