Ganglio sphingolipid metabolism (WP1423)
Homo sapiens
Sphingolipids are metabolites used to make cell-cell and cell-substratum interactions possible. This pathway describes how they are synthesized.
Authors
Kristina Hanspers , Michiel Adriaens , Alex Pico , Egon Willighagen , Martina Summer-Kutmon , Zahra Roudbari , Denise Slenter , and Eric WeitzActivity
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Cited In
- Understanding signaling and metabolic paths using semantified and harmonized information about biological interactions (2022).
- Long Term Culture of the A549 Cancer Cell Line Promotes Multilamellar Body Formation and Differentiation towards an Alveolar Type II Pneumocyte Phenotype (2016).
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Organisms
Homo sapiensCommunities
Annotations
Pathway Ontology
sphingolipid metabolic pathway ganglioside metabolic pathway sphingolipid biosynthetic pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| Fuc-GM1 | Metabolite | chebi:90189 | |
| Fuc-GD1b | Metabolite | chebi:90265 | |
| O-Acetylated GD3 | Metabolite | pubchem.compound:73427362 | |
| GT1aA | Metabolite | lipidmaps:LMSP0601BF00 | |
| GalNAc-GD1a | Metabolite | lipidmaps:LMSP0601BG00 | |
| GQ1bA | Metabolite | lipidmaps:LMSP0601BJ00 | |
| Gal-GD1b | Metabolite | lipidmaps:LMSP0601BH00 | |
| GalNAc-GM1 | Metabolite | lipidmaps:LMSP0601BC00 | |
| GD1aA | Metabolite | lipidmaps:LMSP0601BE00 | |
| GalNAc-GM1b | Metabolite | pubchem.compound:73427345 | |
| GD1A | Metabolite | hmdb:HMDB0011777 | |
| O-Acetylated GT3 | Metabolite | kegg.glycan:G00170 | |
| GT2 | Metabolite | pubchem.compound:53481325 | |
| GD3 | Metabolite | hmdb:HMDB0004913 | |
| GQ1bA | Metabolite | hmdb:HMDB0004928 | |
| GA2 | Metabolite | hmdb:HMDB0004898 | |
| GM1a | Metabolite | hmdb:HMDB0004855 | |
| GD1a | Metabolite | hmdb:HMDB0004853 | |
| GM3 | Metabolite | hmdb:HMDB0004844 | |
| GM1b | Metabolite | pubchem.compound:53239726 | |
| GQ1c | Metabolite | pubchem.compound:53481235 | |
| GT1b | Metabolite | hmdb:HMDB0004927 | |
| GP1c | Metabolite | lipidmaps:LMSP0601AX00 | |
| GA1 | Metabolite | hmdb:HMDB0004910 | |
| GM2 | Metabolite | hmdb:HMDB0004938 | |
| GD1b | Metabolite | hmdb:HMDB0004926 | |
| GT1a | Metabolite | pubchem.compound:45259173 | |
| LacCer | Metabolite | hmdb:HMDB0006750 | |
| GD2 | Metabolite | hmdb:HMDB0004925 | |
| GT1c | Metabolite | pubchem.compound:53481295 | |
| GD1c | Metabolite | lipidmaps:LMSP0601BN00 | |
| GT3 | Metabolite | pubchem.compound:53481355 | |
| B3GALT4 | GeneProduct | ensembl:ENSG00000235863 | 2.4.1.62 |
| B4GALNT1 | GeneProduct | ncbigene:2583 | |
| ST6GALNAC6 | GeneProduct | ensembl:ENSG00000160408 | |
| O-AcetylT | GeneProduct | ensembl:ENSG00000169359 | |
| ST6GALNAC6 | GeneProduct | ncbigene:30815 | |
| B4GALNT1 | GeneProduct | ncbigene:2583 | 2.4.1.92 |
| FUT1 | GeneProduct | ncbigene:2523 | |
| ST8SIA5 | GeneProduct | ensembl:ENSG00000101638 | |
| A3GALT2 | GeneProduct | ncbigene:127550 | |
| ST3GAL2 | GeneProduct | ensembl:ENSG00000157350 | 2.4.99.4 |
| ST3GAL5 | GeneProduct | ncbigene:8869 | |
| ST8SIA5 | GeneProduct | ncbigene:29906 | |
| ST8SIA3 | GeneProduct | ncbigene:51046 | |
| ST3GAL1 | GeneProduct | ensembl:ENSG00000008513 | |
| B3GAL | GeneProduct | ensembl:ENSG00000172318 | |
| GM3 Synthase | GeneProduct | ensembl:ENSG00000115525 | 2.4.99.9 |
| ST8SIA1 | GeneProduct | ensembl:ENSG00000111728 | 2.4.99.8 |
| ST8Sia1 | GeneProduct | ensembl:ENSG00000111728 | 2.4.99.8 |
| ST3GAL2 | GeneProduct | ensembl:ENSG00000157350 |
References
- Sphingolipid and glycosphingolipid metabolic pathways in the era of sphingolipidomics. Merrill AH Jr. Chem Rev. 2011 Oct 12;111(10):6387–422. PubMed Europe PMC Scholia