EPO receptor signaling (WP581)
Homo sapiens
The erythropoietin receptor is a 66 kDa peptide and is a member of the cytokine receptor family. The receptor is tyrosine phosphorylated upon binding by erythropoietin and associates with and activates the tyrosine kinase, JAK2, which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. ''Source: [[wikipedia:Erythropoietin_receptor|Wikipedia]]'' This pathway is based on ScienceSlides. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP581 CPTAC Assay Portal]
Authors
Thomas Kelder , Christine Chichester , Martina Summer-Kutmon , Kristina Hanspers , and Eric WeitzActivity
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Cited In
- DNA methylation of ARHGAP30 is negatively associated with ARHGAP30 expression in lung adenocarcinoma, which reduces tumor immunity and is detrimental to patient survival (2021).
- Hematopoietic stem-cell senescence and myocardial repair - Coronary artery disease genotype/phenotype analysis of post-MI myocardial regeneration response induced by CABG/CD133+ bone marrow hematopoietic stem cell treatment in RCT PERFECT Phase 3 (2020).
- MicroRNAs as potential biomarkers for doxorubicin-induced cardiotoxicity.
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Organisms
Homo sapiensCommunities
CPTAC PancCanNetAnnotations
Pathway Ontology
erythropoietin signaling pathway oxidative phosphorylation pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| EPOR | GeneProduct | ncbigene:2057 | |
| JAK2 | GeneProduct | ncbigene:3717 | |
| SRC | GeneProduct | ncbigene:6714 | |
| STAT1 | GeneProduct | ncbigene:6772 | |
| SHC1 | GeneProduct | ncbigene:6464 | |
| GRB2 | GeneProduct | ncbigene:2885 | |
| MEK1 | GeneProduct | ncbigene:5604 | |
| ERK1 | GeneProduct | ncbigene:5595 | |
| ERK2 | GeneProduct | ncbigene:5594 | |
| MEK2 | GeneProduct | ncbigene:5605 | |
| PDK1 | GeneProduct | ncbigene:5163 | |
| PKB | GeneProduct | ncbigene:207 | |
| PI3K | GeneProduct | ncbigene:5294 | |
| EPO | GeneProduct | ncbigene:2056 | |
| SOCS1 | GeneProduct | ncbigene:8651 | |
| STAT5B | GeneProduct | ncbigene:6777 | |
| CISH | GeneProduct | ncbigene:1154 | |
| STAT5A | GeneProduct | ncbigene:6776 | |
| STAT3 | GeneProduct | ncbigene:6774 | |
| CD45 | GeneProduct | ncbigene:5788 | |
| PTP | GeneProduct | ncbigene:10076 | |
| RAF1 | GeneProduct | ncbigene:5894 | |
| SOS1 | GeneProduct | ncbigene:6654 | |
| IRS2 | GeneProduct | ncbigene:8660 | |
| IRS1 | GeneProduct | ncbigene:3667 | |
| RASA1 | GeneProduct | ncbigene:5921 | |
| RAS | GeneProduct | ncbigene:5921 |
References
- The molecular physiology of erythropoietin and the erythropoietin receptor. Zhu Y, D’Andrea AD. Curr Opin Hematol. 1994 Mar;1(2):113–8. PubMed Europe PMC Scholia
- The molecular biology of erythropoietin. Lacombe C, Mayeux P. Nephrol Dial Transplant. 1999;14 Suppl 2:22–8. PubMed Europe PMC Scholia