Glycerol teichoic acid biosynthesis (WP563)
Saccharomyces cerevisiae
The peptidoglycan layers of many gram-positive bacteria (such as Saccharomyces cerevisiae) are densely functionalized with anionic glycopolymers called wall teichoic acids (WTAs). These polymers play crucial roles in cell shape determination, regulation of cell division, and other fundamental aspects of gram-positive bacterial physiology. Additionally, WTAs are important in pathogenesis and play key roles in antibiotic resistance. Based on http://pathway.yeastgenome.org/biocyc/
Authors
Meredith Braymer , Egon Willighagen , Alex Pico , Denise Slenter , Kristina Hanspers , Eric Weitz , and Lars WillighagenActivity
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Organisms
Saccharomyces cerevisiaeCommunities
Annotations
Pathway Ontology
classic metabolic pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| CTP | Metabolite | chebi:17677 | Cytidine triphosphate |
| UMP | Metabolite | wikidata:Q27074278 | 5'UMP |
| 3 CMP | Metabolite | wikidata:Q412622 | Cytidine monophosphate |
| 3 CDPglycerol | Metabolite | wikidata:Q27102700 | |
| UDP | Metabolite | wikidata:Q412593 | uridine 5'-diphosphate |
| UTP | Metabolite | chebi:15713 | 5'-UTP |
| undecaprenyl phosphate | Metabolite | chebi:27193 | |
| CMP | Metabolite | wikidata:Q412622 | Cytidine monophosphate |
| UDP | Metabolite | wikidata:Q412593 | |
| UDP-D-glucose | Metabolite | chebi:46229 | |
| undecanyl-diphospho-GlcNAc | Metabolite | wikidata:Q312208 | UDP-GlcNAc aka UDP N-acetyl-glucosamine |
| CDPglycerol | Metabolite | wikidata:Q27102700 | Cytidine diphosphate-glycerol |
| Glycerol-3-phosphate | Metabolite | chebi:15978 | |
| UDP-acetylmannosamine | Metabolite | chebi:68678 | |
| UDP-Acetyl-D-glucosamine | Metabolite | chebi:16264 | |
| glucose-6-phosphate | Metabolite | cas:59-56-3 | |
| pyrophosphate | Metabolite | cas:2466-09-3 | |
| glucose-1-phosphate | Metabolite | wikidata:Q27098367 | Assuming closed form |
| PGM2 | GeneProduct | sgd:S000004711 | |
| UGP1 | GeneProduct | sgd:S000001518 | |
| PGM1 | GeneProduct | sgd:S000001610 | |
| YHL012W | GeneProduct | sgd:S000001004 |
References
- Wall teichoic acid function, biosynthesis, and inhibition. Swoboda JG, Campbell J, Meredith TC, Walker S. Chembiochem. 2010 Jan 4;11(1):35–45. PubMed Europe PMC Scholia
- Wall teichoic acids of gram-positive bacteria. Brown S, Santa Maria JP Jr, Walker S. Annu Rev Microbiol. 2013;67:313–36. PubMed Europe PMC Scholia