RNA-polymerase II transcription: the preinitiation complex (WP5563)
Homo sapiens
RNA Polymerase II transcription: the preinitiation complex.
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Authors
Jmlohmann , Egon Willighagen , and Kristina HanspersActivity
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Organisms
Homo sapiensCommunities
Annotations
Pathway Ontology
RNA polymerase II transcription pathway regulatory pathwayReferences
- Identification of promoter elements necessary for transcriptional regulation of a human histone H4 gene in vitro. Hanly SM, Bleecker GC, Heintz N. Mol Cell Biol. 1985 Feb;5(2):380–9. PubMed Europe PMC Scholia
- The TRAP220 component of a thyroid hormone receptor- associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashion. Yuan CX, Ito M, Fondell JD, Fu ZY, Roeder RG. Proc Natl Acad Sci U S A. 1998 Jul 7;95(14):7939–44. PubMed Europe PMC Scholia
- Reconstitution of the transcription factor TFIIH: assignment of functions for the three enzymatic subunits, XPB, XPD, and cdk7. Tirode F, Busso D, Coin F, Egly JM. Mol Cell. 1999 Jan;3(1):87–95. PubMed Europe PMC Scholia
- Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators. Ito M, Yuan CX, Malik S, Gu W, Fondell JD, Yamamura S, et al. Mol Cell. 1999 Mar;3(3):361–70. PubMed Europe PMC Scholia
- NELF, a multisubunit complex containing RD, cooperates with DSIF to repress RNA polymerase II elongation. Yamaguchi Y, Takagi T, Wada T, Yano K, Furuya A, Sugimoto S, et al. Cell. 1999 Apr 2;97(1):41–51. PubMed Europe PMC Scholia
- Human transcription elongation factor NELF: identification of novel subunits and reconstitution of the functionally active complex. Narita T, Yamaguchi Y, Yano K, Sugimoto S, Chanarat S, Wada T, et al. Mol Cell Biol. 2003 Mar;23(6):1863–73. PubMed Europe PMC Scholia
- Fcp1-dependent dephosphorylation is required for M-phase-promoting factor inactivation at mitosis exit. Visconti R, Palazzo L, Della Monica R, Grieco D. Nat Commun. 2012 Jun 12;3:894. PubMed Europe PMC Scholia
- The Mediator complex: a central integrator of transcription. Allen BL, Taatjes DJ. Nat Rev Mol Cell Biol. 2015 Mar;16(3):155–66. PubMed Europe PMC Scholia
- Structure of promoter-bound TFIID and model of human pre-initiation complex assembly. Louder RK, He Y, López-Blanco JR, Fang J, Chacón P, Nogales E. Nature. 2016 Mar 31;531(7596):604–9. PubMed Europe PMC Scholia
- Functional interplay between TFIIH and KAT2A regulates higher-order chromatin structure and class II gene expression. Sandoz J, Nagy Z, Catez P, Caliskan G, Geny S, Renaud JB, et al. Nat Commun. 2019 Mar 20;10(1):1288. PubMed Europe PMC Scholia
- The Cdk8 kinase module regulates interaction of the mediator complex with RNA polymerase II. Osman S, Mohammad E, Lidschreiber M, Stuetzer A, Bazsó FL, Maier KC, et al. J Biol Chem. 2021;296:100734. PubMed Europe PMC Scholia
- The Mediator complex as a master regulator of transcription by RNA polymerase II. Richter WF, Nayak S, Iwasa J, Taatjes DJ. Nat Rev Mol Cell Biol. 2022 Nov;23(11):732–49. PubMed Europe PMC Scholia
- Structures of +1 nucleosome-bound PIC-Mediator complex. Chen X, Wang X, Liu W, Ren Y, Qu X, Li J, et al. Science. 2022 Oct 7;378(6615):62–8. PubMed Europe PMC Scholia
- Structural basis of human Mediator recruitment by the phosphorylated transcription factor Elk-1. Monté D, Lens Z, Dewitte F, Fislage M, Aumercier M, Verger A, et al. Nat Commun. 2025 Apr 22;16(1):3772. PubMed Europe PMC Scholia