Octadecanoid formation from linoleic acid (WP5324)
Homo sapiens
The main enzymatic processes involved in the formation of 18-carbon fatty acids from linoleic acid.
Authors
Conroy lipids , Alex Pico , and Eric WeitzActivity
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Organisms
Homo sapiensCommunities
Lipids and LIPID MAPSAnnotations
Pathway Ontology
lipid signaling pathway lipid metabolic pathway linoleic acid metabolic pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| 9(R)-HODE | Metabolite | lipidmaps:LMFA02000036 | |
| 9,10-epoxy-13-hydroxy-11-octadecenoic acid | Metabolite | lipidmaps:LMFA02000278 | |
| 11-Oxo-9(10)-EpOME | Metabolite | lipidmaps:LMFA02000406 | |
| 10-KODA | Metabolite | lipidmaps:LMFA02000246 | |
| 9(10)-EpOME | Metabolite | lipidmaps:LMFA02000037 | |
| 10-HODA | Metabolite | lipidmaps:LMFA02000128 | |
| 9(S)-HODE | Metabolite | lipidmaps:LMFA02000188 | |
| 17-HODE | Metabolite | lipidmaps:LMFA02000399 | |
| Linoleic acid | Metabolite | lipidmaps:LMFA01030120 | |
| 9-KODE | Metabolite | lipidmaps:LMFA02000274 | |
| 9(E),11(E)-ODEMangold's acid | Metabolite | lipidmaps:LMFA01030119 | |
| 13-oxo-9(10)EpOME | Metabolite | lipidmaps:LMFA02000279 | |
| 12(Z)-10-KOME | Metabolite | lipidmaps:LMFA02000055 | |
| 13-KODE | Metabolite | lipidmaps:LMFA02000016 | |
| 9,12,13-TRiHomes8 isomers | Metabolite | lipidmaps:LMFA02000169 | |
| 9,10-DiHOME | Metabolite | lipidmaps:LMFA02000229 | |
| 13(S)-HpODE | Metabolite | lipidmaps:LMFA02000034 | |
| 10(E)-OME | Metabolite | lipidmaps:LMFA01030075 | |
| 11-OH-9(10)-EpOME | Metabolite | lipidmaps:LMFA02000407 | |
| 9-oxo-12(13)EpOME | Metabolite | lipidmaps:LMFA02000247 | |
| 11(E)-10-HOME | Metabolite | lipidmaps:LMFA01050560 | |
| 9OH-12,13-EpOME | Metabolite | lipidmaps:LMFA02000158 | |
| 11OH-12,13-EpOME | Metabolite | lipidmaps:LMFA02000403 | |
| 13-HODE(both forms) | Metabolite | lipidmaps:LMFA02000154 | |
| 11(E)-10-KOME | Metabolite | lipidmaps:LMFA01060223 | |
| 12,13-DiHOME | Metabolite | lipidmaps:LMFA02000230 | |
| 12(Z)-10-HOME | Metabolite | lipidmaps:LMFA02000345 | |
| 11-oxo-12(13)-EpOME | Metabolite | lipidmaps:LMFA02000404 | |
| 11(S)-HODE | Metabolite | lipidmaps:LMFA02000401 | |
| 9-HODE(both forms) | Metabolite | lipidmaps:LMFA02000151 | Mixture of R and S LMFA02000036/LMFA02000188 |
| 9(Z)-OMEOleic Acid | Metabolite | lipidmaps:LMFA01030002 | |
| 16-HODE | Metabolite | lipidmaps:LMFA02000405 | |
| 9(R)-HpODE | Metabolite | lipidmaps:LMFA02000402 | |
| 13(S)-HODE | Metabolite | lipidmaps:LMFA02000228 | |
| 13(R)-HODE | Metabolite | lipidmaps:LMFA02000035 | |
| 11(R)-HODE | Metabolite | lipidmaps:LMFA02000400 | |
| 9,10,13-TriHOME8 isomers | Metabolite | lipidmaps:LMFA02000168 | |
| 10(E),12(Z)-ODE | Metabolite | lipidmaps:LMFA01030125 | |
| 12(13)-EpOME | Metabolite | lipidmaps:LMFA02000038 | |
| 18-HODE | Metabolite | lipidmaps:LMFA02000398 | |
| 9(Z)-11(E)-ODERumenic Acid | Metabolite | lipidmaps:LMFA01030118 | |
| 13-OH-9(10)-EpOME | Metabolite | lipidmaps:LMFA02000278 | |
| CYP2C19 | GeneProduct | uniprot:P33261 | |
| ALOXE3 | GeneProduct | uniprot:Q9BYJ1 | |
| CYP1A2 | GeneProduct | uniprot:P05177 | |
| GPX4 | GeneProduct | uniprot:P36969 | |
| CYP3A4 | GeneProduct | uniprot:P08684 | |
| PGTS2 | GeneProduct | uniprot:PTGS2 | |
| ALOX12B | GeneProduct | uniprot:O75342 | |
| PGTS1 | GeneProduct | uniprot:P23219 | |
| CYP2C8 | GeneProduct | uniprot:P10632 | |
| CLA-HY | GeneProduct | uniprot:G9MAP1 | |
| CYP2C9 | GeneProduct | uniprot:P11712 | |
| CYP4A11 | GeneProduct | uniprot:Q02928 | |
| ALOX15 | GeneProduct | uniprot:P16050 | |
| EPHX3 | GeneProduct | uniprot:Q9H6B9 |
References
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- A systems approach for discovering linoleic acid derivatives that potentially mediate pain and itch. Ramsden CE, Domenichiello AF, Yuan ZX, Sapio MR, Keyes GS, Mishra SK, et al. Sci Signal. 2017 Aug 22;10(493):eaal5241. PubMed Europe PMC Scholia
- The octadecanoids: an emerging class of lipid mediators. Quaranta A, Revol-Cavalier J, Wheelock CE. Biochem Soc Trans. 2022 Dec 16;50(6):1569–82. PubMed Europe PMC Scholia