Isoglobo series sphingolipids (WP5311)
Homo sapiens
Isoglobo pathway in its entirety from [https://www.lipidmaps.org/resources/sphingomap SphinGOMAP]. Solid conversion arrows are documented according to Sphingomap. Dotted conversions are hypothetical, either not occurring or undocumented (Sphingomap details all possible permutations of a pathway to the final glycolipid). Numbers represent the sphingomap IDs, to be converted. Metabolites coloured red are not yet in LIPIDMAPS Metabolites with a dotted box are hypothetical. These may or may not exist on the pathway to the final product as several different routes could occur.
Authors
Conroy lipids , Egon Willighagen , Andra Waagmeester , Denise Slenter , and Eric WeitzActivity
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Organisms
Homo sapiensCommunities
Lipids and LIPID MAPSAnnotations
Pathway Ontology
lipid metabolic pathway sphingolipid metabolic pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| iGB5 | Metabolite | lipidmaps:LMSP0506AS00 | S_id=354Galβ1-3GalNAcβ1-3Galα1-3Galβ1-4Glcβ-Cer |
| GalNAcbeta1-3Galalpha1-3(Galbeta1-4GlcNAcbeta1-6)Galbeta1-4Glcbeta-Cer | Metabolite | lipidmaps:LMSP0506AK00 | S_id 424ECO:0008028 |
| Galalpha1-3Galbeta1-3GalNAcbeta1-3Galalpha1-3Galbeta1-4Glcbeta-Cer | Metabolite | lipidmaps:LMSP0506BA00 | S_id 381ECO:0008028 |
| iGB4 | Metabolite | lipidmaps:LMSP0506AX00 | s_id 377 |
| Cytolipin R | Metabolite | lipidmaps:LMSP0506AR00 | s_id 353 |
| Galbeta1-3GalNAcbeta1-3Galalpha1-3Galbeta1-4Glcbeta-Cer | Metabolite | lipidmaps:LMSP0506AY00 | S_id 378 |
| iGB3 | Metabolite | lipidmaps:LMSP0506AQ00 | s_id 11Galα1–4Galβ1–4Glcβ1Cer |
| NeuAcα2-IGB5 | Metabolite | lipidmaps:LMSP0601GL00 | s_id 401NeuAcα2-6Galβ1-3GalNAcβ1-3Galα1-3Galβ1-4Glcβ-Cer |
| NeuAcalpha2-3Galbeta1-3GalNAcbeta1-3Galalpha1-3Galbeta1-4Glcbeta-Cer | Metabolite | lipidmaps:LMSP0601GK00 | S_id 379 |
| Galalpha1-3(GalNAcbeta1-4Galbeta1-4GlcNAcbeta1-6)Galbeta1-4Glcbeta-Cer | Metabolite | lipidmaps:LMSP0506AM00 | S_id 427ECO:0008028 |
| HSO3-3Galbeta1-3GalNAcbeta1-3Galalpha1-3Galbeta1-4Glcbeta-Cer | Metabolite | lipidmaps:LMSP0602AO00 | S_id 415 |
| LacCer | Metabolite | chebi:17950 | |
| Galalpha1-3(Fucalpha1-2)Galbeta1-3GalNAcbeta1-3Galalpha1-3Galbeta1-4Glcbeta-Cer | Metabolite | lipidmaps:LMSP0506BC00 | S_id 383 |
| HSO3-3GalNAcbeta1-3Galalpha1-3Galbeta1-4Glcbeta-Cer | Metabolite | lipidmaps:LMSP0602AP00 | S_id 400 |
| GalNAcalpha1-3GalNAcbeta1-3Galalpha1-3(GlcNAcbeta1-6)Galbeta1-4Glcbeta-Cer | Metabolite | lipidmaps:LMSP0506AL00 | S_id 426ECO:0008028 |
| Forssman-like iGb4 | Metabolite | lipidmaps:LMSP0506AD00 | S_id 398 |
| Fucalpha1-2Galbeta1-3GalNAcbeta1-3Galalpha1-3Galbeta1-4Glcbeta-Cer | Metabolite | lipidmaps:LMSP0506BB00 | S_id 382ECO:0008028 |
| NeuAcalpha1-3Galbeta1-4GlcNAcbeta1-3Galalpha1-3Galbeta1-4Glcbeta-Cer | Metabolite | lipidmaps:LMSP0601GW00 | S_id 397ECO:0008028 |
| Galalpha1-3(NeuAcalpha2-3Galbeta1-4GlcNAcbeta1-6)Galbeta1-4Glcbeta-Cer | Metabolite | lipidmaps:LMSP0601GS00 | ECO:0008028 |
| Fucalpha1-3GlcNAcbeta1-3Galalpha1-3(GalNAcbeta1-4)Galbeta1-4Glcbeta-Cer | Metabolite | lipidmaps:LMSP0506BI00 | S_id 395ECO:0008028 |
| Galbeta1-4GlcNAcbeta1-3Galalpha1-3(GalNAcbeta1-4)Galbeta1-4Glcbeta-Cer | Metabolite | lipidmaps:LMSP0506BH00 | S_id 394ECO:0008028 |
| Galbeta1-4(Fucalpha1-3)GlcNAcbeta1-3Galalpha1-3Galbeta1-4Glcbeta-Cer | Metabolite | lipidmaps:LMSP0506AW00 | S_id 375ECO:0008028 |
| GalNAcbeta1-3Galalpha1-3(NeuAcalpha2-3Galbeta1-4GlcNAcbeta1-6)Galbeta1-4Glcbeta-Cer | Metabolite | lipidmaps:LMSP0601GQ00 | S_id 420ECO:0008028 |
| GalNAcbeta1-3Galalpha1-3(GalNAcbeta1-4Galbeta1-4GlcNAcbeta1-6)Galbeta1-4Glcbeta-Cer | Metabolite | lipidmaps:LMSP0506AJ00 | S_id 422ECO:0008028 |
| GalNAcalpha1-3GalNAcbeta1-3Galalpha1-3(Galbeta1-4GlcNAcbeta1-6)Galbeta1-4Glcbeta-Cer | Metabolite | lipidmaps:LMSP0506AI00 | S_id 421ECO:0008028 |
| NeuAcalpha1-3Galbeta1-4GlcNAcbeta1-3Galalpha1-3(GalNAcbeta1-4)Galbeta1-4Glcbeta-Cer | Metabolite | lipidmaps:LMSP0601GV00 | S_id 376ECO:0008028 |
| NeuAcalpha2-3Galbeta1-4(Fucalpha1-3)GlcNAcbeta1-3Galalpha1-3Galbeta1-4Glcbeta-Cer | Metabolite | lipidmaps:LMSP0601GH00 | s_idECO:0008028 |
| GalNAcbeta1-3Galalpha1-3(GalNAcbeta1-4Galbeta1-4GlcNAcbeta1-6)Galbeta1-4Glcbeta-Cer | Metabolite | lipidmaps:LMSP0601GR00 | S_id 423ECO:0008028 |
| NeuAcalpha2-3Galbeta1-4(Fucalpha1-3)GlcNAcbeta1-3Galalpha1-3(GalNAcbeta1-4)Galbeta1-4Glcbeta-Cer | Metabolite | lipidmaps:LMSP0601GI00 | S_id 371 |
| Galbeta1-4(Fucalpha1-3)GlcNAcbeta1-3Galalpha1-3(GalNAcbeta1-4)Galbeta1-4Glcbeta-Cer | Metabolite | lipidmaps:LMSP0506BJ00 | S_id 396ECO:0008028 |
| GalNAcalpha1-3GalNAcbeta1-3Galalpha1-3(GalNAcbeta1-4Galbeta1-4GlcNAcbeta1-6)Galbeta1-4Glcbeta-Cer | Metabolite | lipidmaps:LMSP0506AH00 | S_ID 416ECO:0008028 |
| NeuAcalpha2-3(GalNAcbeta1-4)Galbeta1-4GlcNAcbeta1-6(GalNAcbeta1-3Galalpha1-3)Galbeta1-4Glcbeta-Cer | Metabolite | lipidmaps:LMSP0601GX00 | S_id 399ECO:0008028 |
| GalNAcalpha1-3GalNAcbeta1-3Galalpha1-3(NeuAcalpha2-3Galbeta1-4GlcNAcbeta1-6)Galbeta1-4Glcbeta-Cer | Metabolite | lipidmaps:LMSP0601GP00 | S_id 419ECO:0008028 |
| GalNAcalpha1-3GalNAcbeta1-3Galalpha1-3(NeuAcalpha2-3(GalNAcbeta1-4)Galbeta1-4GlcNAcbeta1-6)Galbeta1-4Glcbeta-Cer | Metabolite | lipidmaps:LMSP0601GO00 | S_id 418 |
| Galalpha1-3(Galbeta1-4GlcNAcbeta1-6)Galbeta1-4Glcbeta-Cer | Metabolite | lipidmaps:LMSP0506AN00 | S_id 429ECO:0008028 |
| GalNAcbeta1-3Galalpha1-3(GlcNAcbeta1-6)Galbeta1-4Glcbeta-Cer | Metabolite | lipidmaps:LMSP0506AO00 | S_id 430ECO:0008028 |
| GalNAcbeta1-3Galalpha1-3Galalpha1-3Galbeta1-4Glcbeta-Cer | Metabolite | lipidmaps:LMSP0506BE00 | S_id 385 |
| Galbeta1-4GlcNAcbeta1-3Galalpha1-3Galbeta1-4Glcbeta-Cer | Metabolite | lipidmaps:LMSP0506AU00 | S_id 373ECO:0008028 |
| Fucalpha1-3GlcNAcbeta1-3Galalpha1-3Galbeta1-4Glcbeta-Cer | Metabolite | lipidmaps:LMSP0506AV00 | s_id 374ECO:0008028 |
| GlcNAcbeta1-3Galalpha1-3(GalNAcbeta1-4)Galbeta1-4Glcbeta-Cer | Metabolite | lipidmaps:LMSP0506BG00 | S-id 393ECO:0008028 |
| Galalpha1-3Galalpha1-3Galbeta1-4Glcbeta-Cer | Metabolite | lipidmaps:LMSP0506AT00 | S_id 372ECO:0008028 |
| Galalpha1-3(GalNAcbeta1-4)Galbeta1-4Glcbeta-Cer | Metabolite | lipidmaps:LMSP0506BF00 | S_id 392ECO:0008028 |
| Fucalpha1-2Galalpha1-3Galbeta1-4Glcbeta-Cer | Metabolite | lipidmaps:LMSP0506AA00 | Sphingolipid ID 411 |
| Galalpha1-3Galalpha1-3Galbeta1-4Glcbeta-Cer | Metabolite | lipidmaps:LMSP0506BD00 | S-id 384ECO:0008028 |
| Galalpha1-3(Fucalpha1-2)Galbeta1-4Glcbeta-Cer | Metabolite | lipidmaps:LMSP0506AZ00 | s_id 380 |
| Galalpha1-3(GlcNAcbeta1-6)Galbeta1-4Glcbeta-Cer | Metabolite | lipidmaps:LMSP0506AP00 | ECO:0008028 |
| β3GalT-V | Protein | uniprot:Q9Y2C3 | AKA β3-Galactosyltransferase (β3GalT) , B3GALT5Annotation based on Book chapter, DOI: 10.1007/978-4-431-67877-9_6 |
References
- SphinGOMAP--a web-based biosynthetic pathway map of sphingolipids and glycosphingolipids. Merril AH Jr. Glycobiology. 2005 Jun;15(6):15G. PubMed Europe PMC Scholia
- Fold-recognition and comparative modeling of human beta3GalT I, II, IV, V and VI and beta3GalNAcT I: prediction of residues conferring acceptor substrate specificity. Patel RY, Balaji PV. J Mol Graph Model. 2007 Jul;26(1):255–68. PubMed Europe PMC Scholia
- Sphingolipid and glycosphingolipid metabolic pathways in the era of sphingolipidomics. Merrill AH Jr. Chem Rev. 2011 Oct 12;111(10):6387–422. PubMed Europe PMC Scholia