Mineralocorticoid biosynthesis (WP5279)
Homo sapiens
Mineralocorticoid synthesis and metabolism, which produce adrenal steroid hormones from cholesterol. These hormones regulate sodium retention in the kidneys and are therefore essential in sodium balance, intravascular volume, and blood pressure [PMID:8839934]. The pathway knowledge depicted in this model stems from William Griffiths. Metabolic reactions currently without a Rhea ID have been added in bold to the pathway model.
Authors
Conroy lipids , Egon Willighagen , Denise Slenter , Lina Schiffer , and Eric WeitzActivity
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Organisms
Homo sapiensCommunities
Annotations
Pathway Ontology
aldosterone biosynthetic pathway mineralocorticoid biosynthetic pathway lipid metabolic pathway classic metabolic pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| 11β,18,21-trihydroxy-5β-pregnan-3,20-dione | Metabolite | lipidmaps:LMST02030277 | |
| Tetrahydrocorticosterone | Metabolite | lipidmaps:LMST02030100 | |
| 5beta-Dihydrocorticosterone | Metabolite | lipidmaps:LMST02030280 | |
| Tetrahydroaldosterone | Metabolite | lipidmaps:LMST02030275 | |
| 3alpha,11beta,18,21-tetrahydroxy-5beta-pregnan-20-one | Metabolite | lipidmaps:LMST02030278 | |
| Allotetrahydrocorticosterone | Metabolite | lipidmaps:LMST02030142 | |
| 5beta-pregnan-21-ol-3,11,20-trione | Metabolite | lipidmaps:LMST02030285 | |
| 18-Hydroxycorticosterone | Metabolite | lipidmaps:LMST02030091 | |
| Aldosterone | Metabolite | lipidmaps:LMST02030026 | |
| 5alpha-pregnan-21-ol-3,11,20-trione | Metabolite | lipidmaps:LMST02030286 | |
| 5beta-dihydrodeoxycorticosterone | Metabolite | lipidmaps:LMST02030282 | |
| 5beta-dihydrodeoxycorticosterone | Metabolite | lipidmaps:LMST02030283 | |
| 18-Hydroxy-11-dehydrotetrahydrocorticosterone | Metabolite | lipidmaps:LMST02030279 | |
| 11-Dehydrocorticosterone | Metabolite | lipidmaps:LMST02030284 | |
| Aldosterone 18-glucuronide | Metabolite | lipidmaps:LMST05010062 | |
| Corticosterone | Metabolite | lipidmaps:LMST02030186 | |
| Alfadolone | Metabolite | lipidmaps:LMST02030287 | |
| 5beta-Dihydroaldosterone | Metabolite | lipidmaps:LMST02030276 | |
| 5alpha-Dihydrocorticosterone | Metabolite | lipidmaps:LMST02030281 | |
| 3alpha,21-dihydroxy-5beta-pregnane-11,20-dione | Metabolite | lipidmaps:LMST02030288 | |
| 11-deoxycorticosterone | Metabolite | lipidmaps:LMST02030087 | |
| Progesterone | Metabolite | lipidmaps:LMST02030159 | |
| AKR1D1 | GeneProduct | uniprot:P51857 | |
| UGT2B7 | GeneProduct | uniprot:P16662 | |
| CYP11B1 | GeneProduct | uniprot:P15538 | |
| AKR1C4 | GeneProduct | uniprot:P17516 | |
| AKR1C3 | GeneProduct | uniprot:P42330 | |
| SRD5A2 | GeneProduct | uniprot:P31213 | |
| UGT1A10 | GeneProduct | uniprot:Q9HAW8 | |
| AKR1C1 | GeneProduct | uniprot:Q04828 | |
| CYP21A2 | GeneProduct | uniprot:P08686 | |
| SRD5A1 | GeneProduct | uniprot:P18405 | |
| HSD11B2 | GeneProduct | uniprot:P80365 | |
| HSD11B1 | GeneProduct | uniprot:P28845 | |
| CYP11B2 | GeneProduct | uniprot:P19099 | |
| AKR1C2 | GeneProduct | uniprot:P52895 |
References
- Molecular biology of mineralocorticoid metabolism. Fardella CE, Miller WL. Annu Rev Nutr. 1996;16:443–70. PubMed Europe PMC Scholia
- Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes: A comprehensive review. Schiffer L, Barnard L, Baranowski ES, Gilligan LC, Taylor AE, Arlt W, et al. J Steroid Biochem Mol Biol. 2019 Nov;194:105439. PubMed Europe PMC Scholia