Estrogen metabolism (WP5276)

Homo sapiens

Authors

Conroy lipids , Egon Willighagen , Lina Schiffer , Denise Slenter , William J Griffiths , and Eric Weitz

Activity

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

lipid metabolic pathway classic metabolic pathway steroid biosynthetic pathway C18-steroid hormone biosynthetic pathway

References

1. Specificity and regioselectivity of the conjugation of estradiol, estrone, and their catecholestrogen and methoxyestrogen metabolites by human uridine diphospho-glucuronosyltransferases expressed in endometrium. Lépine J, Bernard O, Plante M, Têtu B, Pelletier G, Labrie F, et al. J Clin Endocrinol Metab. 2004 Oct;89(10):5222–32. PubMed Europe PMC Scholia
2. Regiospecificity and stereospecificity of human UDP-glucuronosyltransferases in the glucuronidation of estriol, 16-epiestriol, 17-epiestriol, and 13-epiestradiol. Sneitz N, Vahermo M, Mosorin J, Laakkonen L, Poirier D, Finel M. Drug Metab Dispos. 2013 Mar;41(3):582–91. PubMed Europe PMC Scholia
3. Glucuronidation of estrone and 16α-hydroxyestrone by human UGT enzymes: The key roles of UGT1A10 and UGT2B7. Kallionpää RA, Järvinen E, Finel M. J Steroid Biochem Mol Biol. 2015 Nov;154:104–11. PubMed Europe PMC Scholia
4. Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes: A comprehensive review. Schiffer L, Barnard L, Baranowski ES, Gilligan LC, Taylor AE, Arlt W, et al. J Steroid Biochem Mol Biol. 2019 Nov;194:105439. PubMed Europe PMC Scholia