Arsenic metabolism and reactive oxygen species generation (WP5233)

Homo sapiens

Open in new tab Open in Newt (SBGN)
Download PNG Download SVG Download JSON Download GPML Learn more about Downloads
This pathway represents arsenic metabolism and ROS production.

Authors

Zuzanna Lech , Egon Willighagen , Friederike Ehrhart , Martina Summer-Kutmon , and Eric Weitz

Activity

last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.

Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

classic metabolic pathway

Disease Ontology

cancer

Participants
Query Drugst.One

Label Type Compact URI Comment
ROS Metabolite chebi:26523
MMA (V) Metabolite chemspider:8604
Arsenic Metabolite chebi:27563
MMA (III) Metabolite chemspider:141846
S-adenosylmethionine Metabolite chebi:15414
DMA (III) Metabolite chemspider:161508
Arsenic(3+) Metabolite chebi:35828
O2·– Metabolite chebi:18421
Arsenic(5+) Metabolite chebi:35829
GSSG Metabolite chebi:17858
GSH Metabolite chebi:16856
H2O Metabolite chebi:15377
SAH Metabolite chebi:16680
DMA (V) Metabolite chemspider:2418
H2O2 Metabolite chebi:16240
MT-ND1 GeneProduct ensembl:ENSG00000198888
VDAC1 GeneProduct ensembl:ENSG00000213585
SDHA GeneProduct ensembl:ENSG00000073578
COA3 GeneProduct ensembl:ENSG00000183978
SOD2 GeneProduct ensembl:ENSG00000112096
UQCRFS1 GeneProduct ensembl:ENSG00000169021
CAT GeneProduct ensembl:ENSG00000121691
GSTO1 GeneProduct ensembl:ENSG00000148834
SOD1 GeneProduct ensembl:ENSG00000142168
AS3MT GeneProduct ensembl:ENSG00000214435
ATP1A1 GeneProduct ensembl:ENSG00000163399

References

  1. Arsenic: toxicity, oxidative stress and human disease. Jomova K, Jenisova Z, Feszterova M, Baros S, Liska J, Hudecova D, et al. J Appl Toxicol. 2011 Mar;31(2):95–107. PubMed Europe PMC Scholia