Copper metabolism (WP5189)
Homo sapiens
This pathway shows copper metabolism and translocation for two cell types (enterocytes and hepatocytes), as well as associated disorders for transportation of copper to vesicles. Copper is an essential trace element required for the functioning of metalloenzymes. Copper is ingested through diet, absorbed by enterocytes in the intestinal walls, and sent to hepatocytes via the hepatic portal system. This pathway model was constructed using chapter 39 of the book "Physician's Guide to the Diagnosis, Treatment, and Follow-Up of Inherited Metabolic Diseases (first edition)" by Blau (ISBN 3642403360)
Authors
Leo Kalapurackal , Andra Waagmeester , Kristina Hanspers , Denise Slenter , and Eric WeitzActivity
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Organisms
Homo sapiensCommunities
Inherited Metabolic Disorders (IMD) Pathways Rare DiseasesAnnotations
Cell Type Ontology
hepatocyte enterocytePathway Ontology
copper homeostasis pathwayDisease Ontology
MEDNIK syndrome occipital horn syndrome X-linked distal spinal muscular atrophy 3 Menkes disease Wilson diseaseLabel | Type | Compact URI | Comment |
---|---|---|---|
Cu2+ | Metabolite | chebi:29036 | |
Cu+ | Metabolite | chebi:49552 | |
ATP7A | GeneProduct | ensembl:ENSG00000165240 | |
ATP7B | GeneProduct | ensembl:ENSG00000123191 | |
DMT1 | GeneProduct | ensembl:ENSG00000110911 | SLC11A2 is the gene for DMT1 used in copper uptake |
DMT1 | GeneProduct | ensembl:ENSG00000110911 | SLC11A2 is the gene for DMT1 used in copper uptake |
CTR1 | GeneProduct | ensembl:ENSG00000136868 | obtained from SLC31A1 |
References
- Menkes disease. Bertini I, Rosato A. Cell Mol Life Sci. 2008 Jan;65(1):89–91. PubMed Europe PMC Scholia
- MEDNIK syndrome: a novel defect of copper metabolism treatable by zinc acetate therapy. Martinelli D, Travaglini L, Drouin CA, Ceballos-Picot I, Rizza T, Bertini E, et al. Brain. 2013 Mar;136(Pt 3):872–81. PubMed Europe PMC Scholia
- Occipital horn syndrome and classical Menkes Syndrome caused by deep intronic mutations, leading to the activation of ATP7A pseudo-exon. Yasmeen S, Lund K, De Paepe A, De Bie S, Heiberg A, Silva J, et al. Eur J Hum Genet. 2014 Apr;22(4):517–21. PubMed Europe PMC Scholia
- Wilson disease. Członkowska A, Litwin T, Dusek P, Ferenci P, Lutsenko S, Medici V, et al. Nat Rev Dis Primers. 2018 Sep 6;4(1):21. PubMed Europe PMC Scholia
- Copper(II) import and reduction are dependent on His-Met clusters in the extracellular amino terminus of human copper transporter-1. Kar S, Sen S, Maji S, Saraf D, Ruturaj, Paul R, et al. J Biol Chem. 2022 Mar;298(3):101631. PubMed Europe PMC Scholia