Prostaglandin and leukotriene metabolism in senescence (WP5122)
Homo sapiens
Prostaglandin pathway in senescence.
Authors
Doreen Jost , Mario Zubak , Tade Idowu , Denise Kalbe , Fruzsina Magyar , Aysegul Celik , Eric Weitz , and Egon WillighagenActivity
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Cited In
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Organisms
Homo sapiensCommunities
Annotations
Pathway Ontology
aging pathway leukotriene metabolic pathway prostaglandin metabolic pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| PGH2 | Metabolite | chebi:15554 | |
| dihomo-15d-PGJ2 | Metabolite | pubchem.compound:16061095 | |
| ROS | Metabolite | chebi:26523 | |
| PGI2 | Metabolite | chebi:15552 | |
| PGE2 | Metabolite | chebi:15551 | |
| TXA2 | Metabolite | chebi:15627 | |
| PGG2 | Metabolite | chebi:27647 | |
| Adrenic acid | Metabolite | chebi:53487 | |
| Arachidonic acid | Metabolite | hmdb:HMDB01043 | |
| Membrane phospholipids | Metabolite | chebi:16247 | |
| PGD2 | Metabolite | chebi:15555 | |
| cAMP | Metabolite | hmdb:HMDB00058 | |
| 15d-PGJ2 | Metabolite | chebi:34159 | |
| PGF2alpha | Metabolite | chebi:15553 | |
| Ca2+ | Metabolite | chebi:29108 | |
| LTB4 | Metabolite | chebi:15647 | |
| 5-HPETE | Metabolite | hmdb:HMDB11135 | |
| LTD4 | Metabolite | chebi:28666 | |
| p53 | Metabolite | chebi:77731 | |
| LTA4 | Metabolite | chebi:15651 | |
| LTE4 | Metabolite | chebi:15650 | |
| LTC4 | Metabolite | chebi:16978 | |
| PTGES | GeneProduct | ensembl:ENSG00000148344 | |
| Gs | GeneProduct | ensembl:ENSG00000087460 | |
| IGFBP5 | GeneProduct | ensembl:ENSG00000115461 | |
| EP2 (extracellular) | GeneProduct | ensembl:ENSG00000125384 | |
| PTGDS | GeneProduct | ensembl:ENSG00000107317 | |
| COX-1 | GeneProduct | ensembl:ENSG00000095303 | |
| p38 MAPK | GeneProduct | ensembl:ENSG00000185386 | |
| COX-2 | GeneProduct | ensembl:ENSG00000073756 | |
| PGD Synthase | GeneProduct | ensembl:ENSG00000107317 | |
| PGE Synthase | GeneProduct | hgnc.symbol:PTGES | |
| PGI Synthase | GeneProduct | ensembl:ENSG00000124212 | |
| TxA Synthase | GeneProduct | ensembl:ENSG00000059377 | |
| PGF Synthase | GeneProduct | uniprot:Q8TBF2 | |
| EP1 (extracellular) | GeneProduct | ensembl:ENSG00000160951 | |
| EP3 (extracellular) | GeneProduct | ensembl:ENSG00000050628 | |
| EP4 (extracellular) | GeneProduct | ensembl:ENSG00000171522 | |
| Gi | GeneProduct | ensembl:ENSG00000127955 | |
| Gq | GeneProduct | ensembl:ENSG00000156052 | |
| ALOX5AP | GeneProduct | ensembl:ENSG00000132965 | |
| ALOX5 | GeneProduct | ensembl:ENSG00000012779 | |
| LTC4S | GeneProduct | ensembl:ENSG00000213316 | |
| LTA4H | GeneProduct | ensembl:ENSG00000111144 | |
| ALOX15B | GeneProduct | ensembl:ENSG00000179593 | |
| RB1 | GeneProduct | ensembl:ENSG00000139687 | |
| ALOX15 | GeneProduct | ensembl:ENSG00000161905 | |
| SIRT1 | GeneProduct | ensembl:ENSG00000096717 | |
| ALOX12 | GeneProduct | ensembl:ENSG00000108839 | |
| Adenylate Cyclase | Protein | uniprot:A0A0A0MSC1 | |
| Cytosolic phospholipase A2 | Protein | uniprot:P47712 | |
| PLC | Protein | uniprot:A0A087WT80 | |
| RAS | Protein | uniprot:P01112 | |
| p21 | Protein | uniprot:A0A024RCX5 | |
| CysLT1R | Protein | uniprot:Q9Y271 |
References
- 5-Lipoxygenase regulates senescence-like growth arrest by promoting ROS-dependent p53 activation. Catalano A, Rodilossi S, Caprari P, Coppola V, Procopio A. EMBO J. 2005 Jan 12;24(1):170–9. PubMed Europe PMC Scholia
- Lipoxygenase inhibitors for cancer prevention: promises and risks. Menna C, Olivieri F, Catalano A, Procopio A. Curr Pharm Des. 2010;16(6):725–33. PubMed Europe PMC Scholia
- Involvement of IGF binding protein 5 in prostaglandin E(2)-induced cellular senescence in human fibroblasts. Yang HH, Kim C, Jung B, Kim KS, Kim JR. Biogerontology. 2011 Jun;12(3):239–52. PubMed Europe PMC Scholia
- The ATF6α arm of the Unfolded Protein Response mediates replicative senescence in human fibroblasts through a COX2/prostaglandin E2 intracrine pathway. Cormenier J, Martin N, Deslé J, Salazar-Cardozo C, Pourtier A, Abbadie C, et al. Mech Ageing Dev. 2018 Mar;170:82–91. PubMed Europe PMC Scholia
- Leukotriene D4 induces cellular senescence in osteoblasts. Wei J, Chen S, Guo W, Feng B, Yang S, Huang C, et al. Int Immunopharmacol. 2018 May;58:154–9. PubMed Europe PMC Scholia
- Beyond leukotriene formation-The noncanonical functions of 5-lipoxygenase. Häfner AK, Kahnt AS, Steinhilber D. Prostaglandins Other Lipid Mediat. 2019 Jun;142:24–32. PubMed Europe PMC Scholia
- Secretion of leukotrienes by senescent lung fibroblasts promotes pulmonary fibrosis. Wiley CD, Brumwell AN, Davis SS, Jackson JR, Valdovinos A, Calhoun C, et al. JCI Insight. 2019 Dec 19;4(24):e130056. PubMed Europe PMC Scholia
- Lipid Mediators Regulate Pulmonary Fibrosis: Potential Mechanisms and Signaling Pathways. Suryadevara V, Ramchandran R, Kamp DW, Natarajan V. Int J Mol Sci. 2020 Jun 15;21(12):4257. PubMed Europe PMC Scholia
- Fibroblast Senescence in Idiopathic Pulmonary Fibrosis. Lin Y, Xu Z. Front Cell Dev Biol. 2020 Nov 25;8:593283. PubMed Europe PMC Scholia
- Oxylipin biosynthesis reinforces cellular senescence and allows detection of senolysis. Wiley CD, Sharma R, Davis SS, Lopez-Dominguez JA, Mitchell KP, Wiley S, et al. Cell Metab. 2021 Jun 1;33(6):1124-1136.e5. PubMed Europe PMC Scholia