Opioid receptor pathways (WP5093)

Homo sapiens

Opioid signaling from four receptor subtypes.

Authors

Dr. T. S. Keshava Prasad , Eric Weitz , Egon Willighagen , and Kristina Hanspers

Activity

last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.

Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

signaling pathway pertinent to the brain and nervous system

Participants

Label Type Compact URI Comment
Diacylglycerol Metabolite chebi:88364
PIK3CG GeneProduct ncbigene:5294
PLD2 GeneProduct ncbiprotein:NP_002654.3 [Pubmed:16539674] have shown that DAMGO and DPDPE stimulate OPRM1 and OPRD1 respectively and induces activation of PLD2 in an ARF-GTP dependent manner in HEK293 cells
[Pubmed:19519662] have shown that DAMGO stimulates OPRM1 and induces activation of PLD2 in HEK293 cells.
[Pubmed: 19666113] have shown that DAMGO stimulates OPRM1 and induces activation of PLD2 in an ARF6 dependent manner in HEK293 cells and neuronal cells of E17 Sprague-Dawley rats.
NOS2 GeneProduct ncbigene:4843 [Pubmed: 27226238] have shown that U50,488H stimulates OPRK1 and induces downregulation of NOS2 in aorta of hyperlipidemic rats.
[Pubmed: 27226238] have shown that U50,488H stimulates OPRK1 and induces inhibition of NOS2 activity in aorta of hyperlipidemic rats.
PLD2 GeneProduct ncbiprotein:NP_002654.3 Pubmed:16539674] have shown that DAMGO and DPDPE stimulate OPRM1 and OPRD1 respectively and induces activation of PLD2 in an ARF-GTP dependent manner in HEK293 cells
AKT1 GeneProduct ncbiprotein:NP_005154.2 [Pubmed:9722592] have shown that DAMGO stimulates OPRM1 and induces phophorylation of AKT1 at Ser473 in a Gi/G0 coupled-PI3K dependent manner in HEK293 cells.
[Pubmed:26096047] have shown that morphine stimulates OPRM1 and induces phosphorylation of AKT1 at Ser473 in HEK293 cells in a PI3K dependent manner
[Pubmed:15056283] have shown that DAMGO stimulates MOR and induces PI3Kgamma mediated AKT1 phosphorylation at S473 in SHSY5Y and COS7 cells.
[Pubmed:19765550] have shown morphine stimulates MOR and induces phosphorylation of AKT1 at Ser 473 in CEMx174 cells.
OPRM1 GeneProduct ncbigene:4988
GSK3B GeneProduct ncbiprotein:NP_002084.2 [Pubmed:9722592] have shown that DAMGO stimulates OPRM1 and induces phosphorylation of GSK3B at Ser9 in HEK293 cells.
RPS6KB1 GeneProduct ncbiprotein:NP_003152.1 Pubmed 9722592] have shown that DAMGO stimulates OPRM1 and induces phosphorylation of RPS6KB1 at Thr389, Thr421/Ser424 in a PI3K and FRAP/mTOR dependent manner in HEK293 cells.
[Pubmed:9722592] have shown that DAMGO stimulates OPRM1 and induces activation of RPS6KB1 in HEK293 cells.
[Pubmed:26096047] have shown that morphine stimulates OPRM1 and induces phosphorylation of RPS6KB1 at Thr 389 in HEK293 cells in a PI3K-AKT1-MTOR dependent manner.
EIF4EBP1 GeneProduct ncbiprotein:NP_004086.1 [Pubmed:9722592] have shown that DAMGO stimulates OPRM1 and induces phosphorylation of EIF4EBP1 in a PI3K and FRAP/mTOR dependent manner in HEK293 cells.
EIF4EBP2 GeneProduct ncbiprotein:NP_004087.1 [Pubmed:9722592] have shown that DAMGO stimulates OPRM1 and induces phosphorylation of EIF4EBP2 in a PI3K and FRAP/mTOR dependent manner in HEK293 cells.
RPS6KB1 GeneProduct ncbiprotein:NP_003152.1 [Pubmed: 9224649] have shown that DADLE stimulates OPRD1 and induces activation of RPS6KB1 in a Gi/G0, PI3K and FRAP/RAFT dependent manner in D2 cells.
PRKCZ GeneProduct ncbiprotein:NP_005154.2 [Pubmed:21250979] have shown that SNC80 and DPDPE stimulates DOR and induces phosphorylatio of PRKCZ at T410 in a PI3K dependent manner in CHO cells.
[Pubmed: 19682542] have shown that Loperamide stimulates MOR and induces phosphorylation of PRKCZ at Thr 410 in myoblasts C2C12 cells.
PLCB3 GeneProduct ncbiprotein:NP_000923.1 [Pubmed:9572309] have shown that DAMGO stimulates MOR and induces activation of PLCB3 in a Gbetagamma mediated PLCB3 activation in CHO cells.
[Pubmed:19020012] have shown that morphine/DAMGO stimulates MOR and induces Gbetagamma mediated PLCB3 activation in CHO cells.
[Pubmed:9572309] have shown that DPDPE, U-50,488H and DAMGO stimulate DOR, KOR, MOR respectively, and induce activation of PLCB3 in a Galpha16 dependent manner in COS-7 cells.
EEA1 GeneProduct ncbiprotein:NP_003557.3 [Pubmed:20354103] have shown that DAMGO stimulateS OPRM1 and incudes activation of EEA1 in SH-SY5Y cells.
PDGFRB GeneProduct ncbiprotein:NP_002600.1 [Pubmed:16918381] have shown that morphine stimulates MOR and induces phosphorylation of PDGFRB at Y716 in mouse retinal endothelial cells.
KDR GeneProduct ncbiprotein:NP_002244.1 [Pubmed:16918381] have shown that morphine stimulates MOR and induces phosphorylation of KDR at Y1212 in mouse retinal endothelial cells.
CDK5 GeneProduct ncbiprotein:NP_004926.1 [Pubmed:16879821] have shown that DAMGO stimulates OPRM1 and induces activation of CDK5 in SH-SY5Y cells.
STAT3 GeneProduct ncbiprotein:NP_003141.2 [Pubmed: 16918381] have shown that morphine stimulates MOR and induces MOR/KDR mediated STAT3 phosphorylation at Y705 in mouse retinal endothelial cells
[Pubmed:21801866] have shown that DALDA stimulates MOR and induces STAT3 phosphorylation at Tyr 705 in mouse colonocytes.
[Pubmed:16918381] have shown that morphine stimulates MOR and induces translocation of phosphorylated STAT3 from cytosol to nucleus under the influence of MOR/KDR in mouse retinal endothelial cells.
[Pubmed:16879821] have shown that DAMGO stimulates MOR and induces STAT3 phosphorylation at Ser 727 in SH-SY5Y cells.
PDK1 GeneProduct ncbiprotein:NP_001265478.1 [Pubmed:21454526] have shown that DAMGO stimulates MOR and induces phosphorylation of PDK1 at Y373/Y376 in M13 cells
PRKCZ GeneProduct ncbiprotein:NP_002735.3 [Pubmed:21454526] have shown that DAMGO stimulates MOR and induces phosphorylation of PDK1 at Y373/Y376 in M13 cells
PRKCZ GeneProduct ncbiprotein:NP_002735.3 [Pubmed:21454526] have shown that DAMGO stimulates MOR and induces phosphorylation of PRKCZ at Thr 410 in a PDK1 mediated manner in CHO and M13 cells
[Pubmed:21454526] has shown that DAMGO stimulates MOR and induces activation of PRKCZ in M13 cells.
CCR5 GeneProduct ncbiprotein:NP_000570.1 [Pubmed:21454526] have shown that DAMGO stimulates MOR and induces association of CCR5 and activated PRKCZ in M13 cells
CCR5 GeneProduct ncbiprotein:NP_000570.1 [Pubmed:21454526] have shown that DAMGO stimulates MOR and induces phosphorylation of CCR5 at S349 in a PRKCZ dependent manner in M13 cells
IGF1R GeneProduct ncbiprotein:NP_000866.1 [Pubmed: 21515255] have shown that NDMC stimulates DOR and induces phosphorylation of IGF1R at Tyr1135/ Tyr1136 in chinese hamster cells.
GSK3B GeneProduct ncbiprotein:NP_002084.2 [Pubmed: 21515255] have shown that NDMC stimulates DOR and induces phosphorylation of GSK3B at Ser9 in rat nuclear accumbens.
AKT1 GeneProduct ncbiprotein:NP_005154.2 [Pubmed:21250979] have shown that SNC80 and DPDPE stimulates DOR and induces phosphorylation of AKT1 at T308 in a PI3Kalpha dependent manner in CHO cells.
[Pubmed: 21515255] have shown that NDMC stimulates DOR and induces phosphorylation of AKT1 at T308 in rat nuclear accumbens.
[Pubmed:16249373] have shown that DADLE stimulates DOR and induces phophorylation of AKT1 at Ser473 in a PI3K independent manner in murine splenocytes.
STAT3 GeneProduct ncbiprotein:NP_003141.2 [Pubmed: 22033345] have shown that SNC80 stimulates DOR and induces phosphorylation of STAT3 at S727 in rat bone marrow derived mesenchymal stem cells.
CREB1 GeneProduct ncbiprotein:NP_604391.1 [Pubmed: 23682813] have shown that morphine stimulates MOR and induces phosphorylation of CREB1 at S133 in mice striatum
GRIN1 GeneProduct ncbiprotein:NP_001172020.1 [Pubmed:25445489] have shown that morphine stimulates MOR and induces phosphorylation of GRIN1 at S890 in male albino CD1 mice.
GRIN2A GeneProduct ncbiprotein:NP_000824.1 [Pubmed:25445489] have shown that morphine stimulates MOR and induces phosphorylation of GRIN2A at Y1325 in male albino CD1 mice.
CAMK2A GeneProduct ncbiprotein:NP_057065.2 [Pubmed:25445489] have shown that morphine stimulates MOR and induces phosphorylation of CAMK2A at T286 in male albino CD1 mice.
RAC1 GeneProduct ncbigene:5879 [Pubmed: 27634008] have shown that U50488 stimulate KOR and induces the downregulation of RAC1 in mouse hippocampus
BDNF GeneProduct ncbigene:627 [Pubmed: 27634008] have shown that U50488 stimulates KOR and induces the downregulation of BDNF in mouse Hippocampus, prefrontal cortex and primart cortical neurons
AKT1 GeneProduct ncbiprotein:NP_005154.2 [Pubmed:23775075] have shown that U-69,593 stimulates KOR and induces the phosphorylation of AKT1 at S473 in a G alpha i/0 mediated manner in CHO-KOR cells and mice striatal neurons
STAT5B GeneProduct ncbiprotein:NP_036580.2 [Pubmed:23906478] have shown that DSLET stimulates DOR and induces phosphorylation of STAT5B at Y699 in a G alpha i/0 dependent manner in Neuro 2A cells
STAT3 GeneProduct ncbiprotein:NP_003141.2 [Pubmed:23996400] have shown that BRL52537 stimulates KOR and induces phosphorylation of STAT3 at Y705 in ischemia reperfused rat hippocampal CA1 region.
CREB1 GeneProduct ncbiprotein:NP_604391.1 [Pubmed:28097228] have shown that U-50,488H stimulates KOR and induces phosphorylation of CREB1 at S133 in porcine articular chondrocytes.
CASP1 GeneProduct ncbiprotein:NP_150634.1 [Pubmed:26162710] have shown that morphine stimulates MOR and induces cleavage induced activation of CASP1 in a PI3K/AKT mediated manner in rat spinal cord tissue.
IL1B GeneProduct ncbiprotein:3553 [Pubmed:26162710] have shown that morphine stimulates MOR and induces upregulation of IL1B in a PI3K/AKT/CASP1 dependent manner in rat primary spinal neurons.
NOS1 GeneProduct ncbiprotein:NP_001191147.1 [Pubmed:21348811] have shown that morphine stimulates MOR and induces phosphorylation of NOS1 at Ser 1417 activated by AKt1 cascade in mouse PAG synaptosomes.
RGS17 GeneProduct ncbiprotein:NP_036551.3 [Pubmed:21348811] have shown that morphine stimulates MOR induces association of activated NOS1 and RGS17 in mouse PAG synaptosomes.
NOS1 GeneProduct ncbiprotein:NP_001191147.1 [Pubmed:21348811] have shown that morphine stimulates MOR induces association of OPRM1 and NOS1 in mouse PAG synaptosomes.
OPRM1 GeneProduct ncbiprotein:NP_001138751.1 [Pubmed:21348811] have shown that morphine stimulates MOR induces association of activated NOS1 and RGS17 in mouse PAG synaptosomes.
CACNA1B GeneProduct ncbigene:774 [Pubmed:16311589] have shown that nociceptin stimulates ORL1 and induces translocation of OPRL1-CACNA1B complex from cell membrane to cytosol in CHO cells and rat DRG neurons.
PRKCG GeneProduct ncbiprotein:NP_001303258.1 [Pubmed: 25806604] have shown that morphine stimulates MOR and induces phosphorylation of PRKCG at S729 in mouse spinal glial cells.
MAPK8 GeneProduct ncbiprotein:NP_001265476.1 [Pubmed: 25806604] have shown that morphine stimulates MOR and induces phosphorylation of MAPK8 at T183 in mouse spinal glial cells.
MAPK9 GeneProduct ncbiprotein:NP_620709.1 [Pubmed: 25806604] have shown that moprhine stimulates MOR and induces phosphorylation of MAPK9 at Y185 in mosue spinal glial cells
JUN GeneProduct ncbiprotein:NP_002219.1 [Pubmed: 25806604] have shown that morphine stimulates MOR and induces phosphorylation of JUN at S73 in mouse spinal glial cells.
MAPK9 GeneProduct ncbiprotein:NP_620709.1 [Pubmed:15056283] have shown that DAMGO stimulates MOR and U-50,488H stimulates KOR and induces phosphorylation of MAPK9 at Tyr185 in SHSY5Y cells and THP1 cells, respectively.
NFE2L2 GeneProduct ncbiprotein:NP_006155.2 [Pubmed:30595095] have shown that dynorphin A stimulates OPRK1 and induces translocation of NFE2L2 from cytosol to nucleus in rat hippocampal neurons.
EGFR GeneProduct ncbiprotein:NP_005219.2 [Pubmed:17545478] have shown that DADLE stimulates DOR and induces phosphorylation of EGFR at Tyr 1173 in isolated rabbit heart
JUN GeneProduct ncbiprotein:NP_002219.1 [Pubmed:16249373] have shown that DADLE stimulates DOR and induces phosphorylation of JUN at Ser63 in an AKT dependent manner in mouse splenocytes.
AKT GeneProduct refseq:NP_005154.2 [Pubmed:24654606] have shown that morphine stimulates MOR and induces phosphorylation of AKT1 at Ser473 and Thr308 in µ-SK-N-LO cells and mouse sensory DRG neurons.
RELA Protein ncbigene:5970 [Pubmed:23402995] have shown that U50,488H stimulates OPRK1 and induces downregulation of RELA in Male Sprague Dawley rat myocardial infarction and reperfusion heart model.
MAP2K1 Protein ncbiprotein:NP_002746.1 [Pubmed:24061856] have shown that morphine stimulates OPRM1 and induces phosphorylation of MAP2K1 in a RAF1 dependent manner in HEK293 cells
KRAS Protein ncbiprotein:NP_004976.2 [Pubmed:24061856] have shown that morphine stimulates OPRM1 and induces activation of KRAS in HEK293 cells
RAF1 Protein ncbiprotein:NP_001341618.1 [Pubmed:24061856] have shown that morphine stimulates OPRM1 and induces activation of RAF1 in HEK293 cells.
[Pubmed:24061856] have shown that morphine stimulates OPRM1 and induces phosphorylation of RAF1 at Tyr340/341 in HEK293 cells
SRC Protein ncbiprotein:NP_005408.1 Pubmed:24061856] have shown that morphine stimulates OPRM1 and induces phosphorylation of SRC at Tyr416 in HEK293 cells.
AKT1 Protein ncbiprotein:NP_005154.2 [Pubmed:27226238] has shown that U50,488H stimulates OPRK1 and induces phosphorylation of AKT1 at Ser273 in human umbilical vein endothelial cell lines (HUVECs) and aorta of hyperlipidemic rat.
[Pubmed:30595095] have shown that dynorphin A stimulates KOR and induces phosphorylation of AKT1 at Ser 473 in a PI3K dependent manner in rat hippocampal neurons
NOS3 Protein ncbiprotein:NP_000594.2 [Pubmed:27226238] has shown that U50,488H stimulates OPRK1 and induces phosphorylation of NOS3 at Ser1177 in human umbilical vein endothelial cell lines (HUVECs) and aorta of hyperlipidemic rat.
[Pubmed: 27226238] have shown that U50,488H stimulates OPRK1 and induces activation of NOS3 in aorta of hyperlipidemic rats.
OPRD1 Protein ncbiprotein:NP_000902.3 [Pubmed:16539674] have shown that DPDPE stimulates OPRD1 and induces transport of OPRD1 from plasma membrane to cytosol in HEK293 cells.
OPRD1 Protein ncbiprotein:NP_000902.3 [Pubmed:16539674] have shown that DPDPE stimulates OPRD1 and induces transport of OPRD1 from plasma membrane to cytosol in HEK293 cells.
[Pubmed: 10893226] have shown that deltorphinII stimultes OPRD1 and induces transport of OPRD1 from the plasma membrane to cytosol in HEK293 cells.
[Pubmed:10884553] have shown that DTLET stimulates OPRD1 and induces transport of OPRM1 from plasma membrane to cytosol in C6 cells
PRKCE Protein ncbiprotein:NP_005391.1 [Pubmed:24113748] have shown that morphine stimulates OPRM1 and induces activation of PRKCE in HEK293 cells
[Pubmed:20043990] have shown that morphine stimulates OPRM1 and induces activation of PRKCE in HEK293 cells.
[Pubmed: 12750434] have shown that DAMGO stimulates MOR and ORL1 receptor induces translocation of PRKCE from cytosol to plasma membrane in SH-SY5Y cells.
OPRK1 Protein ncbiprotein:NP_001305426.1 [Pubmed:22736766] have shown that 6'-GNTI/EKC/U50488 stimulates KOR and induces activation of OPRK1 in HEK293T cells
[Pubmed: 10334841] have shown that U69,593 stimulates OPRK1 and induces activation of OPRK1 in CHO-K1 cells
PPP3CA Protein ncbiprotein:NP_000935.1 [Pubmed:24113748] have shown that morphine stimulates MOR and induces association of FKBP1A to OPRM1 in HEK293 cells
FKBP1A Protein ncbiprotein:NP_000792.1 [Pubmed:24113748] have shown that morphine stimulates MOR and induces association of FKBP1A to OPRM1 in HEK293 cells
SLC6A3 Protein ncbiprotein:NP_001035.1 [Pubmed:25107591] have shown that SalA, U69,593 and U50,488 stimulates OPRK1 and induces activation of SLC6A3 in a Gi/Go and ERK1/2 dependent manner in EM4 cells
[Pubmed:25107591] have shown that SalA stimulates KOR and induces upregulation of SLC6A3 protein in human EM4 cells and rat striatal synaptosomes.
FOS Protein ncbiprotein:NP_005243.1 [Pubmed:23062312] have shown that U50,488 stimulates OPRK1 and induces activation of FOS in mice hypothalamic arcuate nucleus neurons.
ELK1 Protein ncbiprotein:NP_001107595.1 [Pubmed: 12031654] have shown that morphine or enkaphalin stimulates OPRM1and induces phosphorylation of ELK1 at Ser383 in cord blood hematopoietic stem cells (CD34+ cells).
MAPK1 Protein ncbiprotein:NP_002736.3 [Pubmed:9721727] have shown that Nociceptin and DAMGO stimulates OPRL1 and OPRM1 respectively and induces activation of MAPK1 in CHO-ORL1, CHO-u and COS-7 cells in a Gi/G0, PI3K and SOS activity dependent manner.
MAPK3 Protein ncbiprotein:NP_002736.3 [Pubmed:9721727] have shown that Nociceptin and DAMGO stimulates OPRL1 and OPRM1 respectively and induces activation of MAPK3 in CHO-ORL1, CHO-u and COS-7 cells in a Gi/G0, PI3K and SOS activity dependent manner.
OPRD1 Protein ncbiprotein:NP_000902.3 [Pubmed:24976397] have shown that DAMGO, deltorphinII and DPDPE stimulates OPRM1, OPRM1-OPRD1 heteromer and OPRD1 respectively and induces activation of GNAI3 in rat striatum and hippocampus.
MAPK1 Protein ncbiprotein:NP_002736.3 [Pubmed:24113748] have shown that morphine stimulates OPRM1 and induces phosphorylation of MAPK1 at Thr202 in a PRKCE dependent manner in HEK293 cells.
[Pubmed:15944153] have shown that DAMGO and U-69,593 stimulate MOR and KOR and induce MAPK1 phosphorylation in a PLC/CAM mediated and PI3K mediated manner, respectively in rat cortical astrocytes.
MAPK3 Protein ncbiprotein:NP_002736.3 [Pubmed:24113748] have shown that morphine stimulates OPRM1 and induces phosphorylation of MAPK3 at Tyr204 in a PRKCE dependent manner in HEK293 cells
[Pubmed:15944153] have shown that DAMGO and U-69,593 stimulate MOR and KOR and induce MAPK1 phosphorylation in a PLC/CAM mediated and PI3K mediated manner, respectively in rat cortical astrocytes.
OPRL1 Protein ncbiprotein:NP_001305782.1 [Pubmed: 10334841] have shown that Nociceptin stimulates OPRL1 and induces activation of OPRL1 in CHO-K1 cells
MAPK1 Protein ncbiprotein:NP_002736.3 [Pubmed:10884553] have shown that morphine stimulates OPRM1 and OPRD1; DAMGO and DTLET stimulates OPRM1 and OPRD1 respectively and induces phosphorylation of MAPK1 in CHO and C6 cells
[Pubmed:10884553] have shown that DTLET and DAMGO stimulate OPRD1 and OPRM1 respectively and induces activation of MAPK1 in CHO cells.
[Pubmed: 12031654] have shown that morphine or enkaphalin stimulates OPRM1 and induces phosphorylation of MAPK1 at Thr185/Y187 in cord blood hematopoietic stem cells (CD34+ cells)
Pubmed: 12031654] have shown that morphine or enkaphalin stimulates OPRM1 and induces activation of MAPK1 in cord blood hematopoietic stem cells (CD34+ cells).
[Pubmed:10452557] have shown that morphine and endomorphine-1 stimulate OPRM1 and induces the activation MAPK1 in a PI3K, PTK and PKC dependent manner in CHO- K1 cells
MAPK3 Protein ncbiprotein:NP_002736.3 Pubmed:10884553] have shown that morphine stimulates OPRM1 and OPRD1; DTLET and DAMGO stimulates OPRD1 and OPRM1 respectively and induces phosphorylation of MAPK3 in CHO and C6 cells
[Pubmed:10884553] have shown that DTLET and DAMGO stimulate OPRD1 and OPRM1 respectively and induces activation of MAPK3 in CHO cells.
[Pubmed: 12031654] have shown that morphine or enkaphalin stimulates OPRM1 and induces phosphorylation of MAPK3 at Thr202/Y204 in cord blood hematopoietic stem cells (CD34+ cells)
Pubmed: 12031654] have shown that morphine or enkaphalin stimulates OPRM1 and induces activation of MAPK3 in cord blood hematopoietic stem cells (CD34+ cells).
[Pubmed:10452557] have shown that morphine and endomorphine-1 stimulate OPRM1 and induces the activation MAPK1 in a PI3K, PTK and PKC dependent manner in CHO- K1 cells
MAPK1 Protein ncbiprotein:NP_002736.3 [Pubmed:9224649] have shown that DADLE stimulates OPRD1 and induces activation of MAPK1 in a PI3K independent manner in rat D2 cells.
MAPK3 Protein ncbiprotein:NP_002736.3 [Pubmed:9224649] have shown that DADLE stimulates OPRD1 and induces activation of MAPK3 in a PI3K independent manner in rat D2 cells.
TNF Protein ncbigene:7124 [Pubmed:23402995] have shown taht U50,488H stimulates OPRK1 and induces downregulation of TNF in Male Sprague Dawley rat myocardial infarction and reperfusion heart model.
[Pubmed:22806643] have shown that DAMGO stimulates OPRM1 and induces downregulation of TNF in ischemia and reperfusion heart model of mice.
MTOR Protein ncbiprotein:NP_004949.1 [Pubmed:26096047] have shown that morphine stimulates OPRM1 and induces phosphorylation of MTOR at Ser2448 in HEK293 cells ina PI3K-AKT1 dependent manner.
GPX1 Protein ncbiprotein:NP_000572.2 [Pubmed:19709398] have shown that DADLE stimulates OPRD1 and induces increased activation of GPX1 in ischemia and reperfusion brain model of rats.
CASP3 Protein ncbiprotein:836 [Pubmed:19709398] have shown that DADLE stimulates OPRD1 and induces downregulation of CASP3 in cerebral ischemia and reperfusion brain model of rat.
TLR4 Protein ncbigene:7099 [Pubmed:23402995] have shown that U50,488H stimulates OPRK1 and induces downregulation of TLR4 in Male Sprague Dawley rat's myocardial infarction and reperfusion heart model.
ADCY5 Protein ncbiprotein:NP_000792.1 [Pubmed:24061856] have shown that morphine stimulates MOR and induces association of OPRM1 and ADCY5 in HEK293 cells
ADCY6 Protein ncbiprotein:NP_000792.1 [Pubmed:24061856] have shown that morphine stimulates MOR and induces association of OPRM1 and ADCY6 in HEK293 cells
SRC Protein ncbiprotein:NP_005408.1 [Pubmed:21250979] have shown that SNC80 and DPDPE stimulates DOR and induces phosphorylation of SRC at Y416 in a Gi/G0 dependent manner in CHO cells.
MAPK1 Protein ncbiprotein:NP_002736.3 [Pubmed:21250979] has shown that SNC80 and DPDPE stimulates DOR and induces phosphorylation of MAPK1 in CHO cells.
MAPK3 Protein ncbiprotein:NP_002736.3 [Pubmed:21250979] has shown that SNC80 and DPDPE stimulates DOR and induces phosphorylation of MAPK3 in CHO cells.
MAPK8 Protein ncbiprotein:NP_001265476.1 [Pubmed:15056283] have shown that U-50,488H stimulates KOR and induces phosphorylation of MAPK8 at T183 in THP1 cells.
[Pubmed:26297384] have shown that salvinorin A stimulates KOR and induces phosphorylation of MAPK8 in rat peripheral sensory neurons.
[Pubmed:15056283] have shown that DAMGO stimulates MOR and U-50,488H stimulates KOR and induces activation of MAPK8 in SHSY5Y cells and THP1 cells, respectively.
MAPK8 Protein ncbiprotein:NP_001265476.1 [Pubmed:15056283] have shown that DAMGO stimulates MOR and U-50,488H stimulates KOR and induces activation of MAPK8 in SHSY5Y cells and THP1 cells, respectively.
RAC1 Protein ncbiprotein:NP_061485.1 [Pubmed:15056283] have shown that DAMGO stimulates MOR and induces activation of RAC1 in SHSY5Y and COS7 cells.
CDC42 Protein ncbiprotein:NP_001034891.1 [Pubmed:15056283] have shown that DAMGO stimulates MOR and induces activation of CDC42 in SHSY5Y and COS7 cells.
[Pubmed:14996948] have shown that U-50,488H stimulates OPRK1 and induces activation of CDC42 in a Gbetagamma/SRC-FAK dependent manner in THP1 cells.
OPRD1 Protein ncbiprotein:NP_000902.3 [Pubmed:10334841] have shown that DPDPE stimulates OPRD1 and induces activation of OPRD1 in CHO-K1 cells
[Pubmed:10893226] have shown that deltorphinII stimulates OPRD1 and induces phosphorylation at Ser363 in OPRD1 in HEK293 cells.
[Pubmed:10884553] have shown that DTLET stimulates OPRD1 and induces transport of OPRD1 from cell membrane to cytosol in CHO delta OR cells.
[Pubmed:18463167] have shown that DPDPE stimulates OPRD1 and induces transport of OPRD1 from plasma membrane to cytosol in HEK293 cells
[Pubmed:21422164] have shown that DPDPE stimulates OPRD1 induces transport from plasma membrane to cytosol in HEK293 cells.
SOD1 Protein ncbiprotein:NP_000445.1 [Pubmed:19709398] have shown that DADLE stimulates OPRD1 and induces increased activation of SOD1 in ischemia and reperfusion brain model of rats.
PTK2 Protein ncbiprotein:NP_001339623.1 [Pubmed:14996948] have shown that U-50,488H stimulates OPRK1 and induces phosphorylation of PTK2 at Y397 in THP1 and COS7 cells.
SRC Protein ncbiprotein:NP_005408.1 [Pubmed:14996948] have shown that U-50,488H stimulates OPRK1 and induces phosphorylation of SRC at Y416 in THP1 and COS7 cells
MAPK14 Protein ncbiprotein:NP_001306.1 [Pubmed:23965172] have shown loperamide/fentanyl/methadone/beta-endorphin/morphine stimulate OPRM1 and induce phosphorylation of MAPK14 at T180/Y182 in human T-lymphocytes
[Pubmed:20354103] have shown that DAMGO and DPDPE stimulate OPRM1 and OPRD1 respectively, and incudes activation of MAPK14 in SHSY-5Y cells.
[Pubmed: 12031654] have shown that morphine or enkephalin stimulate MOR and induce phosphorylation of MAPK14 at Thr 180/Tyr 182 in cord blood hematopoietic stem cells (CD34+ cells)
CDK5R1 Protein ncbiprotein:8851 [Pubmed:16879821] have shown that DAMGO stimulates OPRM1 and induces upregulation of CDK5R1 in SH-SY5Y cells and rat embryonic hippocampal neurons.
MAPK1 Protein ncbiprotein:NP_002736.3 [Pubmed:17384143] have shown that deltorphin II stimulates OPRM1-OPRD1 heterodimer to induce beta arrestin 2 mediated MAPK1 phosphorylation in SKNSH cells.
[Pubmed:17384143] have shown that DAMGO stimulates OPRM1 and induces PKC mediated MAPK1 phosphorylation in CHO cells
[Pubmed:23965172] have shown that fentanyl/loperamide/morphine/beta-endorphin/methadone stimulate OPRM1 and induces phosphorylation of MAPK1 in human T-lymphocytes.
[Pubmed: 15647486] have shown that morphine stimulates MOR induces phosphorylation of MAPK1 at Thr 185/Tyr 187 in mouse microglial EOC2 cells.
[Pubmed:31347026] have shown that morphine stimulates MOR and induces phosphorylation of MAPK1 at Thr 185/Tyr 187 under NOTCH1 in mouse spinal cord.
MAPK3 Protein ncbiprotein:NP_002736.3 [Pubmed:17384143] have shown that DAMGO stimulates OPRM1-OPRD1 heterodimer to induce beta arrestin 2 mediated MAPK13 phosphorylation in SKNSH cells.
[Pubmed:23965172] have shown that fentanyl/loperamide/morphine/beta-endorphin/methadone stimulate OPRM1 and induces phosphorylation of MAPK3 in human T-lymphocytes.
[Pubmed:17384143] have shown that DAMGO stimulates OPRM1 and induces PKC mediated MAPK3 phosphorylation in CHO cells
[Pubmed: 15647486] have shown that morphine stimulates MOR and induces phosphorylation of MAPK3 at Thr 202/Tyr 204 in mouse microglial EOC2 cells
[Pubmed:31347026] have shown that morphine stimulates MOR and induces phosphorylation of MAPK3 at Thr 202/Tyr 204 under NOTCH1 in mouse spinal cord.
RPS6KA1 Protein ncbiprotein:NP_002944.2 [Pubmed:17384143] have shown that DAMGO stimulates OPRM1 and OPRM1-OPRD1 heteromer and induces MAPK1/3 mediated phosphorylation of RPS6KA1 at T359/S363 in CHO cells.
GNAI2 Protein ncbiprotein:NP_002061.1 [Pubmed: 20043990] have shown that morphine stimulates MOR and induces phosphorylation of GNAI2 at S44/S144/S302 by PRKCE in HEK293 cells.
MBP Protein ncbiprotein:4155 [Pubmed:22002899] have shown that methadone/Buprenorphine stimulates MOR and induces upregulation of MBP in rat oligodendrocytes.
MAPK9 Protein ncbiprotein:NP_002743.3 [Pubmed:26056051] have shown that morphine and fentanyl stimulate OPRM1 and induce activation of MAPK9 in a Src-PKC dependent and GRK3-ARBB2, Src dependent manner respectively in C57Bl/6 mice
OPRK1 Protein ncbiprotein:NP_001305426.1 [Pubmed:22736766] have shown that EKC/U50,488 stimulates KOR and induces association of OPRK1 and ARR3 in HEK293 cells
ARR3 Protein ncbiprotein:NP_004303.2 [Pubmed:22736766] have shown that EKC/U50488 stimulates KOR and induces association of OPRK1 and ARR3 in HEK293 cells
OPRK1 Protein ncbiprotein:NP_001305426.1 [Pubmed:22736766] have shown that EKC/U50488 stimulates KOR and induces translocation of OPRK1 from plasma membrane to cytoplasm in HEK293T cells.
OPRK1 Protein ncbiprotein:NP_001305426.1 [Pubmed:22736766] have shown that EKC/U50488 stimulates KOR and induces translocation of OPRK1 from plasma membrane to cytoplasm in HEK293T cells.
[Pubmed:23775075] have shown that U-69,593 stimulates KOR and induces translocation of OPRK1 from plasma membrane to endosomein CHHO-KOR cells and mice striatal neurons.
RGS9 Protein ncbigene:8787 [Pubmed:24561386] have shown that morphine stimulates MOR and induces downregulation of RGS9 in mouse D2-type neurons.
MAPK14 Protein ncbiprotein:NP_001306.1 [Pubmed:25857454] has shown that dynorphin stimulates KOR induce phosphorylation of MAPK14 in Chinese Hamster Ovary cell line.
ARRB2 Protein ncbiprotein:NP_001244257.1 [Pubmed:25857454] have shown that dynorphin stimulates OPRK1 and induces translocation of ARBB2 from cytosol to plasma membrane in CHO cells.
CREB1 Protein ncbiprotein:NP_604391.1 [Pubmed: 10708700] have shown that morphine and DPDPE stimulates DOR induce phosphorylation of CREB1 at Ser133 in NG108-15 cells
MAPK1 Protein ncbiprotein:NP_002736.3 [Pubmed: 10646507] have shown that U69,593 stimulates of OPRK1 induces phosphorylation of MAPK1 at Thr185/Tyr187 in C6 glioma cells in a Gβγ subunits and Ras dependent manner
MAPK3 Protein ncbiprotein:NP_002736.3 [Pubmed: 10646507] have shown that U69,593 stimulates KOR induces phosphorylation of MAPK3 at Thr202/Tyr204 in C6 glioma cells in a Gβγ subunit and Ras dependent manner
PTK2B Protein ncbiprotein:NP_775266.1 [Pubmed:10646507] have shown that stimulation of OPRK1 with U69,593 induces Tyr phosphorylation of PTK2B in C6 glioma cell line
FTH1 Protein ncbigene:2498 [Pubmed: 19244528] have shown that Morphine and DAMGO stimulates OPRM1 and induces upregulation of FTH1 in rat cortical neurons and brain homogenates.
RGS4 Protein ncbigene:5999 [Pubmed: 22056472] have shown that morphine stimulates MOR and induces upregulation of RGS4 in rat prefrontal cortex.
MCL1 Protein ncbiprotein:4170 [Pubmed:22033345] have shown that methadone/Buprenorphine stimulates MOR and induces upregulation of MCL1 in rat oligodendrocytes.
RGS4 Protein ncbiprotein:NP_001095915.1 [Pubmed:26119705] have shown that DAMGO stimulates MOR and induces the assciation of RGS4 and OPRM1 in rat brain membrane.
OPRM1 Protein ncbiprotein:NP_001138751.1 [Pubmed:24113748] have shown that morphine stimulates MOR and induces association of FKBP1A to OPRM1 in HEK293 cells
GNAO1 Protein ncbiprotein:NP_620073.2 [Pubmed:26119705] have shown that DAMGO stimulates MOR and induces the assciation of OPRM1 and GNAO1 in rat brain membrane.
OPRM1 Protein ncbiprotein:NP_001138751.1 [Pubmed: 10334841] have shown that DAMGO stimulates OPRM1 and induces activation of OPRM1 in CHO-K1 cells
BCL2 Protein ncbiprotein:596 [Pubmed: 15644942] have shown that endomorphins EM1 and EM2 stimulates MOR induces downregulation of BCL2 in HL60 cells
BAX Protein ncbiprotein:581 [Pubmed: 15644942] have shown that endomorphins EM1 and EM2 stimulates MOR induces upregulation of BAX in HL60 cells
FAS Protein ncbiprotein:355 [Pubmed: 15644942] have shown that endomorphins EM1 and EM2 stimulates MOR induces upregulation of FAS in HL60 cells
FASLG Protein ncbiprotein:356 [Pubmed: 15644942] have shown that endomorphins EM1 and EM2 stimulates MOR induces upregulation of FASLG in HL60 cells
GRK2 Protein ncbiprotein:NP_001610.2 [Pubmed: 12750434] have shown that DAMGO stimulates MOR and ORL1 receptor induces translocation of GRK2 from cytosol to plasma membrane in BE(2)-C cells
GRK3 Protein ncbiprotein:NP_005151.2 [Pubmed: 12750434] have shown that DAMGO stimulates MOR and ORL1 receptor induces translocation of GRK3 from cytosol to plasma membrane in BE(2)-C cells
GATA4 Protein ncbigene:2626 [Pubmed: 12623878] have shown that Dynorphin stimulatesKOR induces upregulation of GATA4 gene in a PKC dependent manner in nuclei isolated from undifferentiated ES cells
NKX2-5 Protein ncbiprotein:1482 [Pubmed: 12623878] have shown that Dynorphin stimulates OPRM1 induces upregulation of NKX2-5 gene in a PKC dependent manner in nuclei isolated from undifferentiated ES cells
PDYN Protein ncbiprotein:5173 [Pubmed: 12623878] have shown that Dynorphin stimulates KOR induces upregulation of PDYN gene in a PKC dependent manner in nuclei isolated from undifferentiated ES cells
ARRB2 Protein ncbiprotein:NP_001244257.1 [Pubmed: 17565992] have shown that DPDPE stimulates association of OPRD1 with ARRB2 in HEK293 cells
ARRB1 Protein ncbiprotein:NP_004032.2 [Pubmed: 17565992] have shown that DPDPE stimulates association of OPRD1 with ARRB1 in HEK293 cells.
CD14 Protein ncbiprotein:929 [Pubmed: 17583593] have shown that morphine stimulates MOR induces downregulation of CD14 expression on the surface of human neutrophils
ADCY1 Protein ncbigene:107 [Pubmed: 23682813] have shown that DAMGO treatment stimulates OPRM1 and induces upregulation of ADCY1 in mice striatum and prefrontal cortex
ADCY8 Protein ncbigene:114 [Pubmed: 23682813] have shown that DAMGO treatment stimulates OPRM1 and induces upregulation of ADCY8 in mice striatum and prefrontal cortex
OPRM1 Protein ncbiprotein:NP_001138751.1 [Pubmed: 26363797] have shown that DAMGO stimulates MOR and induces molecular association of OPRM1 and NISCH in CHO cells
NISCH Protein ncbiprotein:NP_009115.2 [Pubmed: 26363797] have shown that DAMGO stimulates MOR and induces molecular association of OPRM1 and NISCH in CHO cells
SRC Protein ncbiprotein:NP_005408.1 [Pubmed: 27634008] have shown that U50488 and Dynorphin stimulates OPRK1 and induces phosphorylation of SRC at Y416 in mouse primary hippocampal neurons
GRIN2B Protein ncbiprotein:NP_000825.2 [Pubmed: 27634008] have shown that U50488 and Dynorphin stimulates KOR and induces phosphorylation of GRIN2B at Y1472 in mouse primary hippocampus
OPRK1 Protein ncbiprotein:NP_001305426.1 [Pubmed:23775075] have shown that U-69,593 stimulates KOR and induces translocation of OPRK1 from plasma membrane to endosomein CHHO-KOR cells and mice striatal neurons.
[Pubmed:23775075] have shown that U-69,593 stimulates KOR and induces molecular association of OPRK1 and ARRB2 in CHO-KOR cells and mice striatal neurons.
ARRB2 Protein ncbiprotein:NP_001244257.1 [Pubmed:23775075] have shown that U-69,593 stimulates KOR and induces molecular association of OPRK1 and ARRB2 in CHO-KOR cells and mice striatal neurons.
MAPK1 Protein ncbiprotein:NP_002736.3 [Pubmed:23775075] have shown that U-69,593 stimulates KOR and induces phosphorylation of MAPK1 in a G alpha-io dependent manner in CHO-KOR cells and mice striatal neurons.
[Pubmed:25107591] have shown that SalA, U69,593 and U50,488 stimulates OPRK1 and induces phosphorylation of MAPK1 at Thr185/Tyr187 in EM4 cells.
[Pubmed:26297384] have shown that U50,488 stimulates KOR and induces phosphorylation of MAPK1 at Thr185/Tyr187 in rat peripheral sensory neurons
MAPK3 Protein ncbiprotein:NP_002736.3 [Pubmed:23775075] have shown that U-69,593 stimulates KOR and induces phosphorylation of MAPK3 in a G alpha-io dependent in CHO-KOR cells and mice striatal neurons.
[Pubmed: 25107591] have shown that SalA, U69,593 and U50,488 stimulates OPRK1 and induces phosphorylation of MAPK3 at Thr202/Tyr204 in EM4 cells.
[Pubmed:26297384] have shown that U50488 stimulates KOR and induces phosphorylation of MAPK3 at Thr202/Tyr204 in rat peripheral sensory neurons
ITGAM Protein ncbiprotein:3684 [Pubmed:23844255] have shown that TAN-67 stimulates DOR and induces downregulation of ITGAM in rat cortex.
NCAM1 Protein ncbiprotein:4684 [Pubmed:23906478] have shown that DSLET stimulates DOR and induces upregulation of NCAM1 in a STAT5B mediated manner in Neuro 2A cells.
SYP Protein ncbiprotein:6855 [Pubmed:23906478] have shown that DSLET stimulates DOR and induces upregulation of SYP in a STAT5B mediated manner in Neuro 2A cells.
TUBB3 Protein ncbiprotein:10381 [Pubmed:23906478] have shown that DSLET stimulates DOR and induces upregulation of NCAM1 in a STAT5B mediated manner in Neuro 2A cells.
OPRM1 Protein ncbiprotein:NP_001138751.1 [Pubmed:23911290] have shown that morphine stimulates MOR and induces association of OPRM1 and TRPM8 in HEK293 cells.
TRPM8 Protein ncbiprotein:NP_076985.4 [Pubmed:23911290] have shown that morphine stimulates MOR and induces association of OPRM1 and TRPM8 in HEK293 cells.
NTRK2 Protein ncbiprotein:4915 [Pubmed:24055683] have shown that morphine stimulates MOR and induces downregulation of NTRK2 in rat dorsal raphe nucleus.
CRHR1 Protein ncbiprotein:1394 [Pubmed:24055683] have shown that morphine stimulates MOR and induces downregulation of CRHR1 in rat dorsal raphe nucleus.
HTR1A Protein ncbiprotein:3350 [Pubmed:24055683] have shown that morphine stimulates MOR and induces downregulation of HTR1A in rat dorsal raphe nucleus.
PRG4 Protein ncbiprotein:10216 [Pubmed:28097228] have shown that dynorphinA/U-50,488H stimulates KOR and induces upregulation of PRG4 in a cAMP/PKA alpha/CREB dependent manner in human chondrocytes.
OPRM1 Protein ncbiprotein:NP_001138751.1 [Pubmed:22375000] have shown that DAMGO stimulates OPRM1 and induces translocation of OPRM1 from plasma membrane to cytosol in human neuroblastoma SH-SY5Y cells.
[Pubmed:31575621] have shown that DAMGO stimulates OPRM1 and induces phosphorylation of OPRM1 at Ser 363 in a G beta-gamma/PLC/PKC mediated manner in HEK293 cells
ARRB2 Protein ncbiprotein:NP_001244257.1 [Pubmed:22375000] have hown that DAMGO stimulates MOR and induces translocation of ARRB2 from cytosol to plasma membrane in SH-SY5Y cells.
[Pubmed: 22079772] have shown that co-administration of morphine and fentanyl stimulates OPRM1 and induces activation of ARRB2 in rat brain locus coeruleus and periaqueductal gray section
ARRB1 Protein ncbiprotein:NP_004032.2 [Pubmed:22375000] have shown that DAMGO stimulates MOR and induces association of OPRM1 and ARRB1 in human neuroblastoma SH-SY5Y cells
OPRM1 Protein ncbiprotein:NP_001138751.1 [Pubmed:22375000] have shown that DAMGO stimulates MOR and induces association of OPRM1 and ARRB1 in human neuroblastoma SH-SY5Y cells
MAPK14 Protein ncbiprotein:NP_001306.1 Pubmed:25052197] have shown that UFP-512 stimulates DOR and induces phosphorylation of MAPK14 on Thr/Tyr at 180/182 in a MEK/ERK dependent manner in mouse astrocyte culture.
SLC1A3 Protein ncbiprotein:6507 [Pubmed:25052197] have shown that UFP-512 stimulates DOR and induces upregulation of SLC1A3 protein in mouse astrocyte cultures
SLC1A2 Protein ncbiprotein:6506 [Pubmed:25052197] have shown that UFP-512 stimulates DOR and induces upregulation of SLC1A2 protein in mouse astrocyte cultures
ECE2 Protein ncbiprotein:9718 [Pubmed:24990314] have shown that DAMGO/dynorphin B stimulates MOR and induces upregulation of ECE2 in CHO cells.
OPRM1 Protein ncbiprotein:NP_001138751.1 [Pubmed:24990314] have shown that DAMGO/fentanyl/dynorphin B stimulates MOR and induces translocation (recycling) of OPRM1 from endosome to plasma membrane in CHO and F11 cells.
[Pubmed:31575621] have shown that DAMGO stimulates OPRM1 and induces translocation of OPRM1 from endosome to plasma membranel in HEK293 cells
KDR Protein ncbiprotein:3791 [Pubmed:21460241] have shown that U-50,488H/TRK820 stimulates KOR and induces Gi/cAMP/PKA mediated downregulation of KDR in mouse endothelial cels.
NRP1 Protein ncbiprotein:8829 [Pubmed:21460241] have shown that U-50,488H/TRK820 stimulates KOR and induces Gi/cAMP/PKA mediated downregulation of NRP1 in mouse endothelial cels.
AIF1 Protein ncbiprotein:199 [Pubmed:19176808] have shown that morphine stimulates MOR and induces upregulation of AIF1 in rat microglia.
P2RX4 Protein ncbiprotein:5025 [Pubmed:19176808] have shown that morphine stimulates MOR and induces upregulation of P2RX4 in rat microglia.
MAPK1 Protein ncbiprotein:NP_002736.3 [Pubmed: 26763532] have shown that leucine-enkephalin stimulates DOR and induces phosphorylation of MAPK1 in HaCaT cells.
MAPK3 Protein ncbiprotein:NP_002736.3 [Pubmed: 26763532] have shown that leucine-enkephalin stimulates DOR and induces phosphorylation of MAPK3 in HaCaT cells.
RPS6KA1 Protein ncbiprotein:NP_002944.2 [Pubmed: 26763532] have shown that leucine-enkephalin stimulates DOR and induces phosphorylation of RPS6KA1 in HaCaT cells.
ELK1 Protein ncbiprotein:NP_001107595.1 [Pubmed: 26763532] have shown that leucine-enkephalin stimulates DOR and induces phosphorylation of ELK1 in HaCaT cells.
MMP2 Protein ncbiprotein:4313 [Pubmed:26763532] have shown that leucin enkephalin stimulates DOR and induces upregulation of MMP2 in HaCaT cells.
MMP9 Protein ncbiprotein:4318 [Pubmed:26763532] have shown that leucin enkephalin stimulates DOR and induces upregulation of MMP9 in HaCaT cells.
OPRM1 Protein ncbiprotein:NP_001138751.1 [Pubmed:20214800] have shown that morphine stimulates MOR and induces association of OPRM1 and WLS in HEK293 cells.
WLS Protein ncbiprotein:NP_001002292.3 [Pubmed:20214800] have shown that morphine stimulates MOR and induces association of OPRM1 and WLS in HEK293 cells.
OPRL1 Protein ncbigene:4987 [Pubmed:16311589] have shown that nociceptin stimulates ORL1 and induces translocation of OPRL1-CACNA1B complex from cell membrane to cytosol in CHO cells and rat DRG neurons.
E2F1 Protein ncbigene:1869 [Pubmed:19765550] have shown that morphine stimulates MOR and induces upregulation of E2F1 in CEMx174 cells.
E2F1 Protein refseq:NP_005216.1 [Pubmed:19765550] have shown that morphine stimulates MOR and induces association of E2F1 and YY1 in CEMx174 cells.
YY1 Protein ncbiprotein:NP_003394.1 [Pubmed:19765550] have shown that morphine stimulates MOR and induces association of E2F1 and YY1 in CEMx174 cells.
E2F1 Protein refseq:NP_005216.1 [Pubmed:19765550] have shown that morphine stimulates MOR and induces association of E2F1 and SP1 in CEMx174 cells.
SP1 Protein ncbiprotein:NP_612482.2 [Pubmed:19765550] have shown that morphine stimulates MOR and induces association of E2F1 and SP1 in CEMx174 cells.
E2F1 Protein refseq:NP_005216.1 [Pubmed:19765550] have shown that morphine stimulates MOR and induces the DNA binding of E2F1 to MOR promoter in CEMx174 cells.
RGS9 Protein refseq:NP_001075424.1 [Pubmed:15632124] have shown that morphine stimulates MOR and induces phosphorylation of RGS9 at S475 in mouse PAG synaptosomes
GNAI2 Protein refseq:NP_002061.1 [Pubmed:15632124] have shown that morphine stimulates MOR and induces association of RGS9 and GNAI2 in mouse PAG synaptosomes
GNAZ Protein refseq:NP_002064.1 [Pubmed:15632124] have shown that morphine stimulates MOR and induces association of RGS9 and GNAZ in mouse PAG synaptosomes
YWHAQ Protein refseq:NP_006817.1 [Pubmed:15632124] have shown that morphine stimulates MOR and induces association of RGS9 and YWHAQ in mouse PAG synaptosomes
SRC Protein ncbiprotein:NP_005408.1 [Pubmed:24578342] have shown that DPDPE stimulates DOR and induces phosphorylation of SRC at Y416 in rabbit cultured smooth muscle cells
GNAI2 Protein ncbiprotein:NP_002061.1 [Pubmed:24578342] have shown that DPDPE stimulates DOR and induces association of GNAI2 and RGS12 in a Gbeta/gamma-PI2K-cSRC mediated manner in rabbit cultured smooth muscle cells.
RGS12 Protein ncbiprotein:NP_937872.1 [Pubmed:24578342] have shown that DPDPE stimulates DOR and induces association of GNAI2 and RGS12 in a Gbeta/gamma-PI2K-cSRC mediated manner in rabbit cultured smooth muscle cells.
GNAI2 Protein ncbigene:2771 [Pubmed:15987828] have shown that DAMGO stimulates MOR and induces downregulation of GNAI2 in CHO cells.
NEU2 Protein ncbigene:4759 [Pubmed:15987828] have shown that morphine stimulates MOR and induces downregulation of NEU2 in CHO cells.
GNA12 Protein ncbigene:2768 [Pubmed:15987828] have shown that DAMGO stimulates MOR and induces upregulation of GNA12 in CHO cells.
RPLP2 Protein ncbigene:6181 [Pubmed:15987828] have shown that morphine stimulates MOR and induces downregulation of RPLP2 in CHO cells.
JUP Protein ncbigene:3728 [Pubmed:15987828] have shown that morphine stimulates MOR and induces up regulation of JUP in CHO cells.
PGM1 Protein ncbigene:5236 [Pubmed:15987828] have shown that morphine stimulates MOR and induces up regulation of PGM1 in CHO cells.
UBQLN1 Protein ncbiprotein:29979 [Pubmed:15987828] have shown that morphine stimulates MOR and induces up regulation of UBQLN1 in CHO cells.
TUBB Protein ncbigene:203068 [Pubmed:15987828] have shown that morphine stimulates MOR and induces upregulation of TUBB in CHO cells.
HSPA8 Protein ncbigene:3312 [Pubmed:15987828] have shown that morphine stimulates MOR and induces up regulation of HSPA8 in CHO cells.
ALDH9A1 Protein ncbigene:223 [Pubmed:15987828] have shown that morphine stimulates MOR and induces up regulation of ALDH9A1 in CHO cells.
CAMK2A Protein ncbiprotein:NP_057065.2 [Pubmed:16697745] have shown that DPDPE stimulates DOR and induces CAMK2A phosphorylation at Thr286 in rat BDL cholangiocytes
PCNA Protein ncbigene:511
PRKCA Protein ncbiprotein:NP_002728.1 [Pubmed:16697745] have shown that DPDPE stimulates DOR and induces PRKCA phosphorylation at Ser 657 in rat BDL cholangiocytes
PCNA Protein ncbigene:511
ARC Protein ncbigene:23237 [Pubmed:16211563] have shown that morphine stimulates MOR and induces upregulation of ARC in a PKC/MEK dependent manner in mouse striatum and Neuro2A cells.
GCK Protein ncbiprotein:2645 [Pubmed:16140165] have shown that tramadol stimulates OPRM1 and induces upregulation of GCK in rat cortex and hypothalamus.
IRS2 Protein ncbiprotein:8660 [Pubmed:16140165] have shown that tramadol stimulates OPRM1 and induces upregulation of IRS2 in rat primary neuronal cells.
NEUROD1 Protein ncbiprotein:4790 [Pubmed:20554861] have shown that fentanyl stimulates MOR and induces upregulation of NEUROD1 in rat hippocampal neurons.
ADM Protein ncbiprotein:133 [Pubmed:20844145] have shown that morphine stimulates MOR and induces upregulation of ADM in a PKC mediated manner in rat DRG neurons.
CALCA Protein ncbiprotein:796 [Pubmed:20844145] have shown that morphine stimulates MOR and induces upregulation of CALCA in a PKC mediated manner in rat DRG neurons.
GJA1 Protein ncbiprotein:2697 [Pubmed:23011166] have shown that U50,488H stimulates KOR and induces upregulation of GJA1 mRNA in rat ventricles.
GFAP Protein ncbiprotein:2670 [Pubmed: 25806604] have shown that morphine stimulates MOR and induces the upregulation of GFAP in mouse spinal cord.
ARR3 Protein ncbiprotein:NP_004303.2 [Pubmed:22553358] have shown that morphine stimulates MOR and induces OPRM1 and ARR3 association in HEK293 cells
OPRM1 Protein ncbiprotein:NP_001138751.1 [Pubmed:22553358] have shown that morphine stimulates MOR and induces OPRM1 and ARR3 association in HEK293 cells
PIK3R1 Protein ncbiprotein:5295 [Pubmed: 18588537] have shown that chronic morphine treatment stimulates MOR and induces upregulation of PIK3R1 in mouse central extended amygdala
GNAI3 Protein ncbiprotein:NP_006487.1 [Pubmed:24976397] have shown that DAMGO, deltorphinII and DPDPE stimulates MOR, MOR-DOR heteromer and DOR respectively and induces activation of GNAI3 in rat striatum and hippocampi
SLC6A4 Protein ncbiprotein:NP_001036.1 [Pubmed:25107591] have shown that SalA stimulates KOR and induces activation of SLC6A4 in EM4 cells
MAPK8 Protein ncbiprotein:NP_001265476.1 [Pubmed:31347026] have shown that morphine stimulates MOR and induces phosphorylation of MAPK8 at Tyr 185 in mouse spinal cord.
NOTCH1 Protein ncbiprotein:4851 [Pubmed:31347026] have shown that morphine stimulates MOR and induces upregulation of NOTCH1 in mouse spinal cord
PRKCE Protein ncbigene:5581 [Pubmed:31347026] have shown that morphine stimulates MOR and induces upregulation of PRKCE in mouse spinal cord.
PRKCG Protein ncbigene:5582 [Pubmed:31347026] have shown that morphine stimulates MOR and induces upregulation of PRKCG in mouse spinal cord.
HDAC1 Protein ncbigene:3065 [Pubmed:31347026] have shown that morphine stimulates MOR and induces downregulation of HDAC1 in mouse spinal cord.
DNMT3A Protein ncbigene:1788 [Pubmed:31347026] have shown that morphine stimulates MOR and induces upregulation of DNMT3A in mouse spinal cord.
OPRM1 Protein ncbiprotein:NP_001138751.1 [Pubmed:31347026] have shown that morphine stimulates MOR and induces molecular association of OPRM1 and HDAC1 in mouse spinal cord.
PRKCE Protein ncbiprotein:NP_005391.1 [Pubmed:31347026] have shown that morphine stimulates MOR and induces phosphorylation of PRKCE at Ser 729 in mouse spinal cord.
PRKCG Protein ncbiprotein:NP_001303258.1 [Pubmed:31347026] have shown that morphine stimulates MOR and induces phosphorylation of PRKCG at Thr 512 in mouse spinal cord.
HMOX1 Protein ncbigene:3162 [Pubmed:30595095] have shown that dynorphin A stimulates KOR and induces upregulation of HMOX1 in rat hippocampal neurons.
MAP1LC3B Protein ncbigene:81631 [Pubmed:32955950] have shown that BW373U86 stimulates DOR and induces upregulation of MAP1LC3B in hypoxic rat cardiomyocytes.
SQSTM1 Protein ncbigene:8878 [Pubmed:32955950] have shown that BW373U86 stimulates DOR and induces downregulation of SQSTM1 in hypoxic rat cardiomyocytes.
MAPK14 Protein ncbiprotein:NP_001306.1 [Pubmed:10501195] have shown that DPDPE or N/OFQ stimulate DOR and ORL1 respectively and induce phosphorylation of MAPK14 at Thr 180 /Tyr 182 in a PKA dependent manner in NG108-15 cells.
ATF2 Protein ncbiprotein:NP_001871.2 [Pubmed:10501195] have shown that DPDPE and N/OFQ stimulate DOR and ORL1 respectively and induce phosphorylation of ATF2 downstream of MAPK14 in NG108-15 cells.
MBP Protein ncbigene:4155 [Pubmed:10501195] have shown that DPDPE and N/OFQ stimulate DOR and ORL1 respectively and induce upregulation of MBP downstream of MAPK14 in NG108-15 cells.
HDAC1 Protein ncbigene:3065 [Pubmed:31347026] have shown that morphine stimulates MOR and induces molecular association of OPRM1 and HDAC1 in mouse spinal cord.
MAPK1 Protein ncbiprotein:NP_002736.3 [Pubmed:10501195] have shown that DPDPE and N/OFQ stimulate DOR and ORL1 respectively and induce phosphorylation of MAPK1 at Thr185 and Tyr187 in a PKC dependent manner in NG108-15 cells.
MAPK3 Protein ncbiprotein:NP_002736.3 [Pubmed:10501195] have shown that DPDPE and N/OFQ stimulate DOR and ORL1 respectively and induce phosphorylation of MAPK3 at Thr202 and Tyr204 in a PKC dependent manner in NG108-15 cells
OPRM1 Protein ncbiprotein:NP_001138751.1 [Pubmed:24061856] have shown that morphine stimulates MOR and induces phosphorylation of OPRM1 at Tyr336 in HEK293 cells.
BDNF Protein ncbiprotein:627 [Pubmed:24055683] have shown that morphine stimulates MOR and induces downregulation of BDNF in rat dorsal raphe nucleus.

References

  1. MAP kinase activation by mu opioid receptor in cord blood CD34(+)CD38(-) cells. Rozenfeld-Granot G, Toren A, Amariglio N, Nagler A, Rosenthal E, Biniaminov M, et al. Exp Hematol. 2002 May;30(5):473–80. PubMed Europe PMC Scholia
  2. ADP-ribosylation factor 6 regulates mu-opioid receptor trafficking and signaling via activation of phospholipase D2. Rankovic M, Jacob L, Rankovic V, Brandenburg LO, Schröder H, Höllt V, et al. Cell Signal. 2009 Dec;21(12):1784–93. PubMed Europe PMC Scholia
  3. PI3Kγ integrates cAMP and Akt signalling of the μ-opioid receptor. Madishetti S, Schneble N, König C, Hirsch E, Schulz S, Müller JP, et al. Br J Pharmacol. 2014 Jul;171(13):3328–37. PubMed Europe PMC Scholia