Host-pathogen interaction of human coronaviruses - interferon induction (WP4880)
Homo sapiens
Figure 8 of review.
Authors
Friederike Ehrhart , Egon Willighagen , Alex Pico , Chris Evelo , Eric Weitz , Finterly Hu , and Nhung PhamActivity
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Cited In
- An endogenously activated antiviral state restricts SARS-CoV-2 infection in differentiated primary airway epithelial cells (2022).
- Bioinformatics and systems-biology analysis to determine the effects of Coronavirus disease 2019 on patients with allergic asthma (2022).
- Identification of host genomic biomarkers from multiple transcriptomics datasets for diagnosis and therapies of SARS-CoV-2 infections (2023).
- Discovering common pathogenetic processes between COVID-19 and tuberculosis by bioinformatics and system biology approach (2023).
- Combination of Enrichment Using Gene Ontology and Transcriptomic Analysis Revealed Contribution of Interferon Signaling to Severity of COVID-19 (2022).
- Longitudinal Neuropathological Consequences of Extracranial Radiation Therapy in Mice (2024).
- Transcriptional Profiling of SARS-CoV-2-Infected Calu-3 Cells Reveals Immune-Related Signaling Pathways (2024).
- A Practical Strategy for Exploring the Pharmacological Mechanism of Luteolin Against COVID-19/Asthma Comorbidity: Findings of System Pharmacology and Bioinformatics Analysis (2024).
- Parallel use of human stem cell lung and heart models provide insights for SARS-CoV-2 treatment (2023).
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Organisms
Homo sapiensCommunities
COVID-19Annotations
Pathway Ontology
signaling pathway type I interferon signaling pathwayDisease Ontology
severe acute respiratory syndrome viral infectious disease| Label | Type | Compact URI | Comment |
|---|---|---|---|
| MAVS | GeneProduct | ensembl:ENSG00000088888 | |
| TICAM1 | GeneProduct | ncbigene:148022 | TRIF |
| IFIH1 | GeneProduct | ensembl:ENSG00000115267 | MDA5 |
| DDX58 | GeneProduct | ensembl:ENSG00000107201 | RIG1 |
| RIPK1 | GeneProduct | ensembl:ENSG00000137275 | RIP1 |
| IKBKE | GeneProduct | ensembl:ENSG00000263528 | |
| IRF3 | GeneProduct | ensembl:ENSG00000126456 | |
| TRAF6 | GeneProduct | ensembl:ENSG00000175104 | |
| CHUK | GeneProduct | ensembl:ENSG00000213341 | IKKα, IκB kinase α |
| MYD88 | GeneProduct | ensembl:ENSG00000172936 | |
| IKBKB | GeneProduct | ensembl:ENSG00000104365 | IKKb, IκB kinase b |
| TRAF3 | GeneProduct | ensembl:ENSG00000131323 | |
| NFKB1 | GeneProduct | ensembl:ENSG00000109320 | NFKB not specified |
| TBK1 | GeneProduct | ensembl:ENSG00000183735 | |
| JAK1 | GeneProduct | ensembl:ENSG00000162434 | |
| TLR7 | GeneProduct | ensembl:ENSG00000196664 | |
| IKBKG | GeneProduct | ensembl:ENSG00000269335 | NEMO |
| NFKBIA | GeneProduct | ensembl:ENSG00000100906 | IκBα, NF-κB inhibitor alpha |
| OAS1 | GeneProduct | ensembl:ENSG00000089127 | |
| PKR | GeneProduct | ensembl:ENSG00000055332 | |
| MAP3K7 | GeneProduct | ensembl:ENSG00000135341 | TAK1 |
| MAPK8 | GeneProduct | ensembl:ENSG00000107643 | |
| MAPK14 | GeneProduct | ensembl:ENSG00000112062 | |
| JUN | GeneProduct | ensembl:ENSG00000177606 | NFKB not specified |
| FOS | GeneProduct | ensembl:ENSG00000170345 | NFKB not specified |
| IFNAR1 | GeneProduct | ensembl:ENSG00000142166 | |
| IFNAR2 | GeneProduct | ensembl:ENSG00000159110 | |
| TYK2 | GeneProduct | ensembl:ENSG00000105397 | |
| STAT1 | GeneProduct | ensembl:ENSG00000115415 | |
| STAT2 | GeneProduct | ensembl:ENSG00000170581 | |
| IRF9 | GeneProduct | ensembl:ENSG00000213928 | |
| OAS2 | GeneProduct | ensembl:ENSG00000111335 | |
| OAS3 | GeneProduct | ensembl:ENSG00000111331 | |
| PLpro (nsp3) | Protein | refseq:YP_009725299.1 | |
| 6 | Protein | uniprot:P59634 | PDB structure for SARS-CoV strain: 6JYT |
| M | Protein | uniprot:P59596 | PDB structure for SARS-CoV strain: 6JYT |
| N | Protein | wikidata:Q89457519 | PDB structure for SARS-CoV strain: 6JYT |
| 9b | Protein | uniprot:P59636 | PDB structure for SARS-CoV strain: 6JYT |
| E | Protein | uniprot:P59637 | PDB structure for SARS-CoV strain: 6JYT |
| S | Protein | uniprot:694009 | PDB structure for SARS-CoV strain: 6JYT |
| 3a | Protein | uniprot:P59632 | PDB structure for SARS-CoV strain: 6JYT |
| 7a | Protein | uniprot:P59635 | PDB structure for SARS-CoV strain: 6JYT |
| 3b | Protein | uniprot:P59633 | PDB structure for SARS-CoV strain: 6JYT |
References
- Human Coronavirus: Host-Pathogen Interaction. Fung TS, Liu DX. Annu Rev Microbiol. 2019 Sep 8;73:529–57. PubMed Europe PMC Scholia