Linoleic acid metabolism affected by SARS-CoV-2 (WP4853)

Homo sapiens

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Lipid metabolism alternations that are related to infection by corona viruses. The information comes from the Yan et al. in 2019 in the bibliography, particularly Figure 5. That paper uses the HCoV-229E virus as a model. Note that that is different from the virus that causes the 2020 pandemic SARS-CoV-2. Fig 5 is in turn taken from https://www.kegg.jp/kegg-bin/show_pathway?map00591, which is a very simplified pathway, omitting several steps. The paper mentions that after virus infection many of the metabolites in his figure are increased in concentration. Interestingly, exogenous supplement of LA or AA in HCoV-229E-infected cells significantly suppressed HCoV-229E virus replication and this also happened in MERS-CoV.

Authors

Egon Willighagen , Conroy lipids , Chris Evelo , Friederike Ehrhart , Martina Summer-Kutmon , Denise Slenter , Eric Weitz , Cedric Pluis , Lieke Van Den Bogaart , and B.P.E. Mennen

Activity

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Organisms

Homo sapiens

Communities

COVID-19

Annotations

Disease Ontology

Coronavirus infectious disease severe acute respiratory syndrome

Pathway Ontology

linoleic acid metabolic pathway lipid metabolic pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
Omega-6 Metabolite lipidmaps:LMGP01050035
palmitic acid Metabolite lipidmaps:LMFA01010001
Arachidonic acid Metabolite lipidmaps:LMFA01030001
linoleic acid Metabolite lipidmaps:LMFA01030120
LysoPC16:0 Metabolite lipidmaps:LMGP01050113
stearic acid Metabolite wikidata:Q209685
bishomo-gamma-linolenic acid Metabolite lipidmaps:LMFA01030158
oleic acid Metabolite lipidmaps:LMFA01030002
Glycerophospholipids Metabolite chebi:37739
Omega-3 Metabolite lipidmaps:LMFA01030818
gamma-linolenic acid Metabolite lipidmaps:LMFA01030141
CoA(18:2(9Z,12Z)) Metabolite lipidmaps:LMFA07050343
CoA(18:3(6Z,9Z,12Z)) Metabolite lipidmaps:LMFA07050322
CoA(20:3(8Z,11Z,14Z)) Metabolite lipidmaps:LMFA07050278
Arachidonoyl-CoA Metabolite lipidmaps:LMFA07050288 aka CoA(20:4)
Cytosolic phospholipase A2(cPLA2) GeneProduct brenda:3.1.1.4
Linoleoyl-CoAdesaturase GeneProduct brenda:1.14.19.3
ACE2 GeneProduct ensembl:ENSG00000130234
ACOT2 GeneProduct ensembl:ENSG00000119673 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:171210
ELOVL2 GeneProduct ensembl:ENSG00000197977 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:54326
ELOVL5 GeneProduct ensembl:ENSG00000012660 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:68801
FADS1 GeneProduct ensembl:ENSG00000149485 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:76267
FADS2 Protein uniprot:O95864
surfaceglycoprotein S Protein uniprot:P0DTC2
membraneglycoprotein M Protein uniprot:P0DTC5
nucleocapsidprotein N Protein uniprot:P0DTC9
envelopeprotein E Protein uniprot:P0DTC4

References

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