Purine metabolism (WP4792)
Homo sapiens
Overview of purine metabolism. Metabolic markers are highlighted in red, with graphical arrows indicating if a marker is present in higher or lower concentrations compared to normal (healthy) levels. This pathway was inspired by Chapter 13, edition 5 of the book of Blau (in press). The full version including disorders, based on ed. 4, can be found [https://www.wikipathways.org/index.php/Pathway:WP4224 here]. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP4792 CPTAC Assay Portal]
Authors
Denise Slenter , Martina Summer-Kutmon , Lauren J. Dupuis , Finterly Hu , Egon Willighagen , and Eric WeitzActivity
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Organisms
Homo sapiensCommunities
Inherited Metabolic Disorders (IMD) Pathways Rare DiseasesAnnotations
Pathway Ontology
purine metabolic pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| PRPP | Metabolite | chebi:17111 | |
| ATP | Metabolite | chebi:30616 | |
| XMP | Metabolite | chebi:57464 | |
| SAICARP | Metabolite | chebi:58443 | |
| AICA-riboside | Metabolite | chebi:28498 | |
| AMP | Metabolite | chebi:456215 | |
| Xanthosine | Metabolite | chebi:18107 | |
| 2'-Deoxyadenosine | Metabolite | chebi:17256 | |
| Inosine | Metabolite | chebi:17596 | |
| GDP | Metabolite | chebi:58189 | |
| Ribose-5-P | Metabolite | chebi:52742 | |
| SAICA-riboside | Metabolite | chebi:18319 | |
| dGDP | Metabolite | chebi:58595 | |
| Succinyladenosine | Metabolite | chebi:71169 | |
| dATP | Metabolite | chebi:61404 | |
| AICARP | Metabolite | chebi:58475 | |
| 2,8-Dihydroxyadenine | Metabolite | wikidata:Q4596812 | |
| dADP | Metabolite | chebi:57667 | |
| Adenosine | Metabolite | chebi:16335 | |
| dAMP | Metabolite | chebi:58245 | |
| ITP | Metabolite | chebi:61402 | is a nucleoside triphosphate(4−) |
| Hypoxanthine | Metabolite | chebi:17368 | |
| Guanosine | Metabolite | chebi:16750 | |
| S-AMP | Metabolite | chebi:57567 | succinyladenosine monophosphate |
| Xanthine | Metabolite | chebi:17712 | |
| ADP | Metabolite | chebi:456216 | |
| GTP | Metabolite | chebi:37565 | |
| dGTP | Metabolite | chebi:16497 | |
| Urate | Metabolite | chebi:17775 | |
| Adenine | Metabolite | chebi:16708 | |
| Guanine | Metabolite | chebi:16235 | |
| dGMP | Metabolite | chebi:57673 | |
| FAICARP | Metabolite | chebi:58467 | |
| 2-Deoxyguanosine | Metabolite | chebi:17172 | |
| GMP | Metabolite | chebi:58115 | |
| 2'-deoxyinosine | Metabolite | chebi:28997 | |
| IMP | Metabolite | chebi:58053 | |
| APRT | Protein | uniprot:P07741 | |
| ATIC | Protein | uniprot:P31939 | |
| ADA | Protein | uniprot:P00813 | aka Adenosine deaminase |
| ADSL | Protein | uniprot:P30566 | |
| PRPS1 | Protein | uniprot:P60891 | |
| ADSS | Protein | uniprot:P30520 | Adenylosuccinate synthetase isozyme 2 |
| PRPPs | Protein | eccode:2.7.6.1 | |
| IMPDH1 | Protein | uniprot:P20839 | |
| HPRT1 | Protein | uniprot:P00492 | |
| DGUOK | Protein | uniprot:Q16854 | |
| AMPD1 | Protein | uniprot:P23109 | |
| PNP | Protein | uniprot:P00491 | |
| ITPA | Protein | uniprot:Q9BY32 | |
| RR | Protein | eccode:1.17.4.1 | ribonucleotide reductase |
| XO | Protein | uniprot:P47989 | |
| RR | Protein | eccode:1.17.4.1 | |
| ADA | Protein | uniprot:P00813 |
References
- Combined Immune Deficiencies. Su HC, Lenardo MJ. In: Stiehm’s Immune Deficiencies [Internet]. Elsevier; 2014. p. 143–69. Available from: http://dx.doi.org/10.1016/B978-0-12-405546-9.00005-4 DOI Scholia
- Physician’s Guide to the Diagnosis, Treatment, and Follow-Up of Inherited Metabolic Diseases [Internet]. Blau N, Duran M, Gibson KM, Vici CD. Springer; 2014. 867 p. Available from: https://play.google.com/store/books/details?id=t9i6BQAAQBAJ OpenLibrary Worldcat