Netrin-UNC5B signaling (WP4747)

Homo sapiens

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UNC-5 Homolog B (UNC5B) is a member of the dependence receptor family. It can induce two opposite intracellular signaling cascades depending on the presence or absence of the ligand and is thus capable of driving two opposing processes. UNC5B signaling has been implicated in several cancers, where it promotes cell death in the absence of its ligand netrin-1 and increases cell survival in its presence. In addition, inhibition of the ligand has been reported to decrease invasiveness and angiogenesis in tumors. UNC5B signaling pathway has also been reported to be involved in several processes such as neural development, developmental angiogenesis and inflammatory processes. Interaction of UNC5B with netrins activates various signaling modules including ERK1/ERK2, p38 MAPK signaling and PI3k-AKT pathway modules

Authors

Yashwanth Subbannayya , Friederike Ehrhart , Lauren J. Dupuis , Marvin Martens , Denise Slenter , Eric Weitz , and Egon Willighagen

Activity

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Disease Ontology

cancer

Pathway Ontology

cancer pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
NTN1 GeneProduct ncbigene:9423
NTN3 GeneProduct ncbigene:4917
NTN4 GeneProduct ncbigene:59277
DAPK1 GeneProduct ncbigene:1612
PPP1CA GeneProduct ncbigene:5499
NEO1 GeneProduct ncbigene:4756
ARHGEF12 GeneProduct ncbigene:23365
RGMA GeneProduct ncbigene:56963
DCSTAMP GeneProduct ncbigene:81501
PRKCA GeneProduct ncbigene:5578
PPP2R1B GeneProduct ncbigene:5519
SRC GeneProduct ncbigene:6714
CIP2A GeneProduct ncbigene:57650
AGAP2 GeneProduct ncbigene:116986
FYN GeneProduct ncbigene:2534
YAP1 GeneProduct ncbigene:10413
INPP5D GeneProduct ncbigene:3635
PLEKHH1 GeneProduct ncbigene:57475
PTPN11 GeneProduct ncbigene:5781
AKT1 GeneProduct ncbigene:207
JUN GeneProduct ncbigene:3725
PTK2B GeneProduct ncbigene:2185
GSK3B GeneProduct ncbigene:4617
TP53 GeneProduct ncbigene:7157
PIK3CA GeneProduct ncbigene:5290
RAC1 GeneProduct ncbigene:5879
RHOA GeneProduct ncbigene:387
UNC5B GeneProduct ncbigene:219699
ITGB4 GeneProduct ncbigene:3691
IL6 GeneProduct ncbigene:6018
CCL2 GeneProduct ncbigene:6347
PTK2 GeneProduct ncbigene:5747
RAF1 GeneProduct ncbigene:5894
MAP2K1 GeneProduct ncbigene:5604
MAP2K2 GeneProduct ncbigene:5605
MAPK1 GeneProduct ncbigene:5594
MAPK3 GeneProduct ncbigene:5595
PPP2CA GeneProduct ncbigene:5499
CTGF GeneProduct ncbigene:1490
PTPA GeneProduct ncbigene:5524
TNF GeneProduct ncbigene:7124
IL1A GeneProduct ncbigene:3552
IL10 GeneProduct ncbigene:3586
COL1A GeneProduct ncbigene:1277
ALPL GeneProduct ncbigene:249
ICAM1 GeneProduct ncbigene:3383
VCAM1 GeneProduct ncbigene:7412
SELE GeneProduct ncbigene:6401
MAPK14 GeneProduct ncbigene:1432
CASP3 GeneProduct ncbigene:836
ROBO4 GeneProduct ncbigene:54538
KDR GeneProduct ncbigene:3791
CDH5 GeneProduct ncbigene:1003
Protein Protein ncbigene:5894

References

  1. Netrin-3, a mouse homolog of human NTN2L, is highly expressed in sensory ganglia and shows differential binding to netrin receptors. Wang H, Copeland NG, Gilbert DJ, Jenkins NA, Tessier-Lavigne M. J Neurosci. 1999 Jun 15;19(12):4938–47. PubMed Europe PMC Scholia
  2. Netrin-1 acts as a survival factor via its receptors UNC5H and DCC. Llambi F, Causeret F, Bloch-Gallego E, Mehlen P. EMBO J. 2001 Jun 1;20(11):2715–22. PubMed Europe PMC Scholia
  3. MAX-1, a novel PH/MyTH4/FERM domain cytoplasmic protein implicated in netrin-mediated axon repulsion. Huang X, Cheng HJ, Tessier-Lavigne M, Jin Y. Neuron. 2002 May 16;34(4):563–76. PubMed Europe PMC Scholia
  4. Oxytocin improves long-lasting spatial memory during motherhood through MAP kinase cascade. Tomizawa K, Iga N, Lu YF, Moriwaki A, Matsushita M, Li ST, et al. Nat Neurosci. 2003 Apr;6(4):384–90. PubMed Europe PMC Scholia
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  12. Unc5B associates with LARG to mediate the action of repulsive guidance molecule. Hata K, Kaibuchi K, Inagaki S, Yamashita T. J Cell Biol. 2009 Mar 9;184(5):737–50. PubMed Europe PMC Scholia
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  14. Netrin-1 regulates Th1/Th2/Th17 cytokine production and inflammation through UNC5B receptor and protects kidney against ischemia-reperfusion injury. Tadagavadi RK, Wang W, Ramesh G. J Immunol. 2010 Sep 15;185(6):3750–8. PubMed Europe PMC Scholia
  15. The dependence receptor UNC5H2/B triggers apoptosis via PP2A-mediated dephosphorylation of DAP kinase. Guenebeaud C, Goldschneider D, Castets M, Guix C, Chazot G, Delloye-Bourgeois C, et al. Mol Cell. 2010 Dec 22;40(6):863–76. PubMed Europe PMC Scholia
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