Sphingolipid metabolism: integrated pathway (WP4726)

Homo sapiens

Authors

Denise Slenter , Kristina Hanspers , Eric Weitz , Conroy lipids , and Egon Willighagen

Activity

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Cited In

• Identification of the effects of COVID-19 on patients with pulmonary fibrosis and lung cancer: a bioinformatics analysis and literature review (2022).
• Tissue-specific pathway activities: A retrospective analysis in COVID-19 patients (2022).
• Reconstructed Human Skin with Hypodermis Shows Essential Role of Adipose Tissue in Skin Metabolism (2024).

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Organisms

Homo sapiens

Communities

Lipids and LIPID MAPS

Annotations

Pathway Ontology

cholesterol biosynthetic pathway sphingolipid biosynthetic pathway sphingomyelin metabolic pathway sphingolipid metabolic pathway

References

1. Characterization of murine sphingosine-1-phosphate phosphohydrolase. Le Stunff H, Peterson C, Thornton R, Milstien S, Mandala SM, Spiegel S. J Biol Chem. 2002 Mar 15;277(11):8920–7. PubMed Europe PMC Scholia
2. De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway. Merrill AH Jr. J Biol Chem. 2002 Jul 19;277(29):25843–6. PubMed Europe PMC Scholia
3. Mammalian Lass6 and its related family members regulate synthesis of specific ceramides. Mizutani Y, Kihara A, Igarashi Y. Biochem J. 2005 Aug 15;390(Pt 1):263–71. PubMed Europe PMC Scholia
4. LASS5 is a bona fide dihydroceramide synthase that selectively utilizes palmitoyl-CoA as acyl donor. Lahiri S, Futerman AH. J Biol Chem. 2005 Oct 7;280(40):33735–8. PubMed Europe PMC Scholia
5. Kinetic characterization of mammalian ceramide synthases: determination of K(m) values towards sphinganine. Lahiri S, Lee H, Mesicek J, Fuks Z, Haimovitz-Friedman A, Kolesnick RN, et al. FEBS Lett. 2007 Nov 13;581(27):5289–94. PubMed Europe PMC Scholia
6. A mouse macrophage lipidome. Dennis EA, Deems RA, Harkewicz R, Quehenberger O, Brown HA, Milne SB, et al. J Biol Chem. 2010 Dec 17;285(51):39976–85. PubMed Europe PMC Scholia
7. Ceramide Synthase 5 Is Essential to Maintain C16:0-Ceramide Pools and Contributes to the Development of Diet-induced Obesity. Gosejacob D, Jäger PS, Vom Dorp K, Frejno M, Carstensen AC, Köhnke M, et al. J Biol Chem. 2016 Mar 25;291(13):6989–7003. PubMed Europe PMC Scholia