Omega-9 fatty acid synthesis (WP4724)
Homo sapiens
This pathway is inspired by the Lipidmaps>Omega-9 and other fatty acids [1]. Omega-9 FAs (Fatty acids) are fats which can be obtained from diet, but also produced endogenously. These lipids are monounsaturated (indicating one double bonds in the lipid tail).The position of the double bond is counted from the tail end of the lipid chain. This pathway also indicated saturated fats (without a double bond), such as stearic acid, arachidic acid etc.
For a description of pathway objects, see the WikiPathways Legend.
Authors
Denise Slenter , Eric Weitz , Egon Willighagen , and Daniela DiglesActivity
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Cited In
- The differential expression of adipose tissue genes in short, medium and long-term periods after bariatric surgery (2024).
- Etodolac Single Dose Metabolic Profile Elucidation: Pharmacokinetics and Adverse Events in Healthy Volunteers (2025).
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Organisms
Homo sapiensCommunities
Lipids and LIPID MAPS ONTOXAnnotations
Pathway Ontology
unsaturated fatty acid biosynthetic pathway fatty acid elongation pathway fatty acid metabolic pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| CoA(20:0) | Metabolite | lipidmaps:LMFA07050329 | |
| Lauric acid | Metabolite | lipidmaps:LMFA01010012 | |
| Myristic acid | Metabolite | lipidmaps:LMFA01010014 | |
| CoA(16:0) | Metabolite | lipidmaps:LMFA07050360 | |
| CoA(16:1(9Z)) | Metabolite | lipidmaps:LMFA07050359 | |
| CoA(18:1(9Z)) | Metabolite | lipidmaps:LMFA07050356 | |
| CoA(18:2(6Z,9Z)) | Metabolite | lipidmaps:LMFA07050060 | |
| CoA(20:1(11Z)) | Metabolite | lipidmaps:LMFA07050093 | |
| CoA(20:2(8Z,11Z)) | Metabolite | lipidmaps:LMFA07050061 | |
| 18:2(6Z,9Z) | Metabolite | lipidmaps:LMFA07050060 | |
| Stearic acid | Metabolite | lipidmaps:LMFA01010018 | |
| 16:1(9Z) | Metabolite | lipidmaps:LMFA01030056 | |
| CoA(18:0) | Metabolite | lipidmaps:LMFA07050369 | |
| Palmitic acid | Metabolite | lipidmaps:LMFA01010001 | |
| CoA(22:0) | Metabolite | lipidmaps:LMFA07050289 | |
| CoA(24:0) | Metabolite | lipidmaps:LMFA07050372 | |
| CoA(26:0) | Metabolite | lipidmaps:LMFA07050327 | |
| Arachidic acid | Metabolite | lipidmaps:LMFA01010020 | |
| Behenic acid | Metabolite | lipidmaps:LMFA01010022 | |
| Lignoceric acid | Metabolite | lipidmaps:LMFA01010024 | |
| Cerotic acid | Metabolite | lipidmaps:LMFA01010026 | |
| CoA(22:1(13Z)) | Metabolite | lipidmaps:LMFA07050318 | |
| CoA(24:1(15Z)) | Metabolite | lipidmaps:LMFA07050098 | |
| 20:2(8Z,11Z) | Metabolite | lipidmaps:LMFA01030377 | |
| CoA(20:3(5Z,8Z,11Z)) | Metabolite | lipidmaps:LMFA07050062 | |
| 20:3(5Z,8Z,11Z) | Metabolite | lipidmaps:LMFA01030381 | |
| Oleic acid | Metabolite | lipidmaps:LMFA01030002 | |
| 24:1(15Z)) | Metabolite | lipidmaps:LMFA01030377 | AKA cis-selacholeic acid |
| cis-erucic acid | Metabolite | cas:112-86-7 | AKA cis-selacholeic acid |
| FADS1 | GeneProduct | ensembl:ENSG00000149485 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:76267 |
| ACSL1 | GeneProduct | ensembl:ENSG00000151726 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14081 |
| FASN | GeneProduct | ensembl:ENSG00000169710 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14104 |
| ACSL3 | GeneProduct | ensembl:ENSG00000123983 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74205 |
| ACSL4 | GeneProduct | ensembl:ENSG00000068366 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:50790 |
| ELOVL2 | GeneProduct | ensembl:ENSG00000197977 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:54326 |
| ELOVL5 | GeneProduct | ensembl:ENSG00000012660 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:68801 |
| ELOVL6 | GeneProduct | ensembl:ENSG00000170522 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:170439 |
| ELOVL3 | GeneProduct | ensembl:ENSG00000119915 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12686 |
| ELOVL1 | GeneProduct | ensembl:ENSG00000066322 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:54325 |
| FADS2 | GeneProduct | ensembl:ENSG00000134824 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:56473 |
| ACOT2 | GeneProduct | ensembl:ENSG00000119673 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:171210 |
| SCD5 | Protein | uniprot:Q86SK9 | AKA SCD2, hSCD2. Soucre: [https://www.uniprot.org/uniprot/Q86SK9].'highly expressed in brain' [PMID:22745828]; 'most abundantly expressed in pancreas and brain' [PMID:15610069], 'transcripts from adult and foetal tissues exhibit different sizes because of alternative splicing in the non-coding region, suggesting that hSCD2 (aka SCD5, red.) expression is developmentally regulated.' [PMID:15610069] |
| hSCD1 | Protein | uniprot:O00767 | No homologues found for original id L:20250 (Scd2) Human ortholog is SCD, which had mouse orthologs Scd2 and Scd4.'SCD catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA' Source:[https://www.uniprot.org/uniprot/O00767].'predominantly expressed in liver' [PMID:15610069]. |
References
- Characterization of human SCD2, an oligomeric desaturase with improved stability and enzyme activity by cross-linking in intact cells. Zhang S, Yang Y, Shi Y. Biochem J. 2005 May 15;388(Pt 1):135–42. PubMed Europe PMC Scholia
- Characterization of HSCD5, a novel human stearoyl-CoA desaturase unique to primates. Wang J, Yu L, Schmidt RE, Su C, Huang X, Gould K, et al. Biochem Biophys Res Commun. 2005 Jul 8;332(3):735–42. PubMed Europe PMC Scholia
- A mouse macrophage lipidome. Dennis EA, Deems RA, Harkewicz R, Quehenberger O, Brown HA, Milne SB, et al. J Biol Chem. 2010 Dec 17;285(51):39976–85. PubMed Europe PMC Scholia