Omega-9 fatty acid synthesis (WP4724)

Homo sapiens

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Authors

Denise Slenter and Eric Weitz

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

Lipids and LIPID MAPS

Annotations

Pathway Ontology

fatty acid elongation pathway fatty acid metabolic pathway unsaturated fatty acid biosynthetic pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
CoA(20:0) Metabolite lipidmaps:LMFA07050329
Lauric acid Metabolite lipidmaps:LMFA01010012
Myristic acid Metabolite lipidmaps:LMFA01010014
CoA(16:0) Metabolite lipidmaps:LMFA07050360
CoA(16:1(9Z)) Metabolite lipidmaps:LMFA07050359
CoA(18:1(9Z)) Metabolite lipidmaps:LMFA07050356
CoA(18:2(6Z,9Z)) Metabolite lipidmaps:LMFA07050060
CoA(20:1(11Z)) Metabolite lipidmaps:LMFA07050093
CoA(20:2(8Z,11Z)) Metabolite lipidmaps:LMFA07050061
18:2(6Z,9Z) Metabolite lipidmaps:LMFA07050060
Stearic acid Metabolite lipidmaps:LMFA01010018
16:1(9Z) Metabolite lipidmaps:LMFA01030056
CoA(18:0) Metabolite lipidmaps:LMFA07050369
Palmitic acid Metabolite lipidmaps:LMFA01010001
CoA(22:0) Metabolite lipidmaps:LMFA07050289
CoA(24:0) Metabolite lipidmaps:LMFA07050372
CoA(26:0) Metabolite lipidmaps:LMFA07050327
Arachidic acid Metabolite lipidmaps:LMFA01010020
Behenic acid Metabolite lipidmaps:LMFA01010022
Lignoceric acid Metabolite lipidmaps:LMFA01010024
Cerotic acid Metabolite lipidmaps:LMFA01010026
CoA(22:1(13Z)) Metabolite lipidmaps:LMFA07050318
CoA(24:1(15Z)) Metabolite lipidmaps:LMFA07050098
20:2(8Z,11Z) Metabolite lipidmaps:LMFA01030377
CoA(20:3(5Z,8Z,11Z)) Metabolite lipidmaps:LMFA07050062
20:3(5Z,8Z,11Z) Metabolite lipidmaps:LMFA01030381
Oleic acid Metabolite lipidmaps:LMFA01030002
24:1(15Z)) Metabolite lipidmaps:LMFA01030377 AKA cis-selacholeic acid
cis-erucic acid Metabolite cas:112-86-7 AKA cis-selacholeic acid
FADS1 GeneProduct ensembl:ENSG00000149485 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:76267
ACSL1 GeneProduct ensembl:ENSG00000151726 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14081
FASN GeneProduct ensembl:ENSG00000169710 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14104
ACSL3 GeneProduct ensembl:ENSG00000123983 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74205
ACSL4 GeneProduct ensembl:ENSG00000068366 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:50790
ELOVL2 GeneProduct ensembl:ENSG00000197977 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:54326
ELOVL5 GeneProduct ensembl:ENSG00000012660 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:68801
ELOVL6 GeneProduct ensembl:ENSG00000170522 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:170439
ELOVL3 GeneProduct ensembl:ENSG00000119915 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12686
ELOVL1 GeneProduct ensembl:ENSG00000066322 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:54325
FADS2 GeneProduct ensembl:ENSG00000134824 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:56473
ACOT2 GeneProduct ensembl:ENSG00000119673 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:171210
SCD5 Protein uniprot:Q86SK9 AKA SCD2, hSCD2. Soucre: [https://www.uniprot.org/uniprot/Q86SK9].
'highly expressed in brain' [PMID:22745828]; 'most abundantly expressed in pancreas and brain' [PMID:15610069], 'transcripts from adult and foetal tissues exhibit different sizes because of alternative splicing in the non-coding region, suggesting that hSCD2 (aka SCD5, red.) expression is developmentally regulated.' [PMID:15610069]
hSCD1 Protein uniprot:O00767 No homologues found for original id L:20250 (Scd2) Human ortholog is SCD, which had mouse orthologs Scd2 and Scd4.
'SCD catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA' Source:[https://www.uniprot.org/uniprot/O00767].
'predominantly expressed in liver' [PMID:15610069].

References

  1. Characterization of human SCD2, an oligomeric desaturase with improved stability and enzyme activity by cross-linking in intact cells. Zhang S, Yang Y, Shi Y. Biochem J. 2005 May 15;388(Pt 1):135–42. PubMed Europe PMC Scholia
  2. Characterization of HSCD5, a novel human stearoyl-CoA desaturase unique to primates. Wang J, Yu L, Schmidt RE, Su C, Huang X, Gould K, et al. Biochem Biophys Res Commun. 2005 Jul 8;332(3):735–42. PubMed Europe PMC Scholia
  3. A mouse macrophage lipidome. Dennis EA, Deems RA, Harkewicz R, Quehenberger O, Brown HA, Milne SB, et al. J Biol Chem. 2010 Dec 17;285(51):39976–85. PubMed Europe PMC Scholia