Eicosanoid metabolism via lipooxygenases (LOX) (WP4721)

Homo sapiens

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Authors

Denise Slenter , Eric Weitz , and Egon Willighagen

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

Lipids and LIPID MAPS

Annotations

Pathway Ontology

lipoxygenase mediated pathway of arachidonic acid metabolism eicosanoid metabolic pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
12(R)-HpETE Metabolite lipidmaps:LMFA03060070
LTA4 Metabolite lipidmaps:LMFA03020023
Arachidonic acid Metabolite lipidmaps:LMFA01030001
15-HpETE Metabolite lipidmaps:LMFA03060014 'Various cell types metabolize arachidonic acid to 15(S)-hydroperoxyeicosatetraenoic acid (15(S)-HpETE). This initial hydroperoxide product is extremely short-lived in cells: if not otherwise metabolized, it is rapidly reduced to 15(S)-HETE.' [https://en.wikipedia.org/wiki/15-Hydroxyeicosatetraenoic_acid]
15-HETE Metabolite lipidmaps:LMFA03060087 'Various cell types metabolize arachidonic acid to 15(S)-hydroperoxyeicosatetraenoic acid (15(S)-HpETE). This initial hydroperoxide product is extremely short-lived in cells: if not otherwise metabolized, it is rapidly reduced to 15(S)-HETE.' [https://en.wikipedia.org/wiki/15-Hydroxyeicosatetraenoic_acid]
8-HpETE Metabolite lipidmaps:LMFA03060073
8-HETE Metabolite lipidmaps:LMFA03060086
15-oxoETE Metabolite lipidmaps:LMFA03060051
LXA4 Metabolite lipidmaps:LMFA03040001
12-HpETE Metabolite lipidmaps:LMFA03060013 AKA 12S-HpETE
12-HETE Metabolite lipidmaps:LMFA03060088
12-oxoETE Metabolite lipidmaps:LMFA03060019
HXB3 Metabolite lipidmaps:LMFA03090003
HXA3 Metabolite lipidmaps:LMFA03090005
TXA3 Metabolite lipidmaps:LMFA03030005
TXB3 Metabolite lipidmaps:LMFA03030006
LXB4 Metabolite lipidmaps:LMFA03040002
LTB4 Metabolite lipidmaps:LMFA03020001
12-epi-LTB4 Metabolite lipidmaps:LMFA03020015
6-trans-12-epi-delta-LTB4 Metabolite lipidmaps:LMFA03020014
6-trans-delta-LTB4 Metabolite lipidmaps:LMFA03020013
LTC4 Metabolite lipidmaps:LMFA03020003
LTD4 Metabolite lipidmaps:LMFA03020006
LTE4 Metabolite lipidmaps:LMFA03020002
EXC4 Metabolite lipidmaps:LMFA03020031
EXD4 Metabolite lipidmaps:LMFA03020032
EXE4 Metabolite lipidmaps:LMFA03020033
20-hydroxy-LTB4 Metabolite lipidmaps:LMFA03020018
20-carboxy-LTB4 Metabolite lipidmaps:LMFA03020016
18-carboxy-dinor-LTB4 Metabolite lipidmaps:LMFA03020056
11-trans-LTC4 Metabolite lipidmaps:LMFA03020020
11-trans-LTD4 Metabolite lipidmaps:LMFA03020021
11-trans-LTE4 Metabolite lipidmaps:LMFA03020022
5-HpETE Metabolite lipidmaps:LMFA03060108
5-HETE Metabolite lipidmaps:LMFA03060084
5-oxoETE Metabolite lipidmaps:LMFA03060011
15-oxo-LXA4 Metabolite lipidmaps:LMFA03040009
13,14-dihydro-15-oxo-LXA4 Metabolite lipidmaps:LMFA03040008
12-oxo-LTB4 Metabolite lipidmaps:LMFA03020024
5,12-diHETE Metabolite lipidmaps:LMFA03060052
CYP4A11 GeneProduct ensembl:ENSG00000187048 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13117
LTA4H GeneProduct ensembl:ENSG00000111144 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16993
ALOX5 GeneProduct ensembl:ENSG00000012779 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11689
ALOX15 GeneProduct ensembl:ENSG00000161905 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11687
HPGD GeneProduct ensembl:ENSG00000164120 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15446
ALOX12 GeneProduct ensembl:ENSG00000108839 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11684
LTC4S GeneProduct ensembl:ENSG00000213316 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17001
CYP4A22 GeneProduct ensembl:ENSG00000162365 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:277753
CYP4A22 GeneProduct ensembl:ENSG00000162365 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13118
CYP4F12 GeneProduct ensembl:ENSG00000186204 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:64385
CYP4F2 GeneProduct ensembl:ENSG00000186115 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:72054
ACOX1 GeneProduct ensembl:ENSG00000161533 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11430
ACOX2 GeneProduct ensembl:ENSG00000168306 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:93732
ACOX3 GeneProduct ensembl:ENSG00000087008 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:80911
EHHADH GeneProduct ensembl:ENSG00000113790 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74147
ACAA1 GeneProduct ensembl:ENSG00000060971 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:113868
GGT5 GeneProduct ensembl:ENSG00000099998 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:23887
DPEP1 GeneProduct ensembl:ENSG00000015413 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13479
PTGR1 GeneProduct ensembl:ENSG00000106853 AKA Ltb4dh
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:67103
PTGR2 GeneProduct ensembl:ENSG00000140043 AKA Zadh1
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:77219
LTB4R Protein ensembl:ENSG00000213903 AKA Leukotriene B4 receptor 1[https://en.wikipedia.org/wiki/Leukotriene_B4_receptor_1]
Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:O88855
ALOX15B Protein ensembl:ENSG00000179593 Alox15b (also termed 8-lipoxygenase, 8-lox, and 15-lipoxygenase type II) [https://en.wikipedia.org/wiki/Lipoxygenase#Mouse_lipoxygenases]
Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:O35936
LTB4R2 Protein ensembl:ENSG00000213906 AKA Leukotriene B4 receptor 2, also known as BLT2, BLT2 receptor, and BLTR2 [https://en.wikipedia.org/wiki/Leukotriene_B4_receptor_2]
Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q9JJL9
PPARA Protein ensembl:ENSG00000186951 AKA Peroxisome proliferator-activated receptor alpha
Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:P23204
CYSLTR1 Protein ensembl:ENSG00000173198 AKA Cysteinyl leukotriene receptor 1, also termed CYSLTR1 [https://en.wikipedia.org/wiki/Cysteinyl_leukotriene_receptor_1]
Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q99JA4
CYSLTR2 Protein ensembl:ENSG00000152207 AKA Cysteinyl leukotriene receptor 2, also termed CYSLTR [https://en.wikipedia.org/wiki/Cysteinyl_leukotriene_receptor_2]
Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q920A1
FPR2 Protein ensembl:ENSG00000171049 AKA N-formyl peptide receptor 2 (FPR2), because of its interaction with lipoxin A4, FPR2 is also commonly named the ALX/FPR2 or just ALX receptor. [https://en.wikipedia.org/wiki/Formyl_peptide_receptor_2]
Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:O88536
ALOX15 Protein ensembl:ENSG00000161905 Alox15 (also termed leukocyte-type 12-Lox, 12-Lox-l, and 12/15-Lox) [https://en.wikipedia.org/wiki/Lipoxygenase#Mouse_lipoxygenases]
Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:P39654
ALOX12 Protein ensembl:ENSG00000108839 Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:P39655
PPARD Protein ensembl:ENSG00000112033 AKA Peroxisome proliferator-activated receptor beta or delta (PPAR-β or PPAR-δ) [https://en.wikipedia.org/wiki/Peroxisome_proliferator-activated_receptor_delta]
Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:P35396
TRPA1 Protein ensembl:ENSG00000104321 AKA Transient receptor potential cation channel, subfamily A, member 1, also known as transient receptor potential ankyrin 1 or TRPA1 [https://en.wikipedia.org/wiki/TRPA1]
Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q8BLA8
TRPV1 Protein ensembl:ENSG00000196689 AKA The transient receptor potential cation channel subfamily V member 1 (TrpV1), also known as the capsaicin receptor and the vanilloid receptor 1 [https://en.wikipedia.org/wiki/TRPV1]
Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q704Y3
ALOX5 Protein ensembl:ENSG00000012779 AKA Arachidonate 5-lipoxygenase, also known as ALOX5, 5-lipoxygenase, 5-LOX, or 5-LO [https://en.wikipedia.org/wiki/Arachidonate_5-lipoxygenase]
Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:P48999
ALOX15 Protein ensembl:ENSG00000161905 AKA ALOX15 (also termed arachidonate 15-lipoxygenase, 15-lipoxygenase-1, 15-LO-1, 15-LOX-1) [https://en.wikipedia.org/wiki/ALOX15]
Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:P39654

References

  1. New aspects of the role of hydroxyeicosatetraenoic acids in cell growth and cancer development. Moreno JJ. Biochem Pharmacol. 2009 Jan 1;77(1):1–10. PubMed Europe PMC Scholia
  2. A mouse macrophage lipidome. Dennis EA, Deems RA, Harkewicz R, Quehenberger O, Brown HA, Milne SB, et al. J Biol Chem. 2010 Dec 17;285(51):39976–85. PubMed Europe PMC Scholia
  3. Eicosanoid storm in infection and inflammation. Dennis EA, Norris PC. Nat Rev Immunol. 2015 Aug;15(8):511–23. PubMed Europe PMC Scholia