Measles virus infection (WP4630)

Homo sapiens

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The measles virus is a single-stranded, negative-sense virus that exclusively infects humans. The measles virus has two surface proteins responsible for binding and fusion to target cells: hemagglutinin (H) and membrane fusion protein (F). Multiple receptors have been identified to bind these surface proteins: CD46, SLAM, Nectin-4 and TLR. The viral proteins P, V and C suppress the innate immune response by inhibiting signaling for both type I IFN induction and JAK/STAT-mediated interferon-stimulated gene (ISG) induction. The virus also causes inhibition of IL-12 expression in dendritic cells, via H proteins on viral particles as well as N proteins from infected cells. This pathway is based on [https://www.genome.jp/kegg-bin/show_pathway?hsa05162 KEGG].

Authors

Kristina Hanspers , Egon Willighagen , Finterly Hu , and Eric Weitz

Activity

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Organisms

Homo sapiens

Communities

CPTAC

Annotations

Cell Type Ontology

lymphocyte dendritic cell epithelial cell

Disease Ontology

measles viral infectious disease

Pathway Ontology

signaling pathway pertinent to immunity

Participants
Query Drugst.One

Label Type Compact URI Comment
LPS Metabolite chebi:16412
NECTIN4 GeneProduct ensembl:ENSG00000143217
CSNK2A2 GeneProduct ensembl:ENSG00000070770
CSNK2A1 GeneProduct ensembl:ENSG00000101266
EIF2AK2 GeneProduct ensembl:ENSG00000055332
F GeneProduct ncbiprotein:AAB26145.1
STAT3 GeneProduct ensembl:ENSG00000168610
IRF7 GeneProduct ensembl:ENSG00000185507
CDKN1B GeneProduct ensembl:ENSG00000111276
TLR7 GeneProduct ensembl:ENSG00000196664
IFNA8 GeneProduct ensembl:ENSG00000120242
OAS1 GeneProduct ensembl:ENSG00000089127
EIF2AK1 GeneProduct ensembl:ENSG00000086232
HSPA1A GeneProduct ensembl:ENSG00000204389
IFNA14 GeneProduct ensembl:ENSG00000228083
EIF2S1 GeneProduct ensembl:ENSG00000134001
IFNA6 GeneProduct ensembl:ENSG00000120235
V GeneProduct ncbiprotein:AB481088.1
HSPA6 GeneProduct ensembl:ENSG00000173110
JAK1 GeneProduct ensembl:ENSG00000162434
IFNA16 GeneProduct ensembl:ENSG00000147885
EIF2AK3 GeneProduct ensembl:ENSG00000172071
IRF3 GeneProduct ensembl:ENSG00000126456
CCND1 GeneProduct ensembl:ENSG00000110092
IFNA13 GeneProduct ensembl:ENSG00000233816
HSPA8 GeneProduct ensembl:ENSG00000109971
IFNB1 GeneProduct ensembl:ENSG00000171855
TRADD GeneProduct ensembl:ENSG00000102871
IFNA10 GeneProduct ensembl:ENSG00000186803
CSNK2A3 GeneProduct ensembl:ENSG00000254598
FADD GeneProduct ensembl:ENSG00000168040
EIF2AK4 GeneProduct ensembl:ENSG00000128829
BID GeneProduct ensembl:ENSG00000015475
CASP8 GeneProduct ensembl:ENSG00000064012
FAS GeneProduct ensembl:ENSG00000026103
IRF9 GeneProduct ensembl:ENSG00000213928
CD3D GeneProduct ensembl:ENSG00000167286
IFNA5 GeneProduct ensembl:ENSG00000147873
RCHY1 GeneProduct ensembl:ENSG00000163743
TNFAIP3 GeneProduct ensembl:ENSG00000118503
DDX58 GeneProduct ensembl:ENSG00000107201
CSNK2B GeneProduct ensembl:ENSG00000204435
TP53 GeneProduct ensembl:ENSG00000141510
CD28 GeneProduct ensembl:ENSG00000178562
CBLB GeneProduct ensembl:ENSG00000114423
IFNA7 GeneProduct ensembl:ENSG00000214042
FASLG GeneProduct ensembl:ENSG00000117560
RAB9A GeneProduct ensembl:ENSG00000123595
IFNA2 GeneProduct ensembl:ENSG00000188379
CD46 GeneProduct ensembl:ENSG00000117335
BBC3 GeneProduct ensembl:ENSG00000105327
EIF3H GeneProduct ensembl:ENSG00000147677
CYCS GeneProduct ensembl:ENSG00000172115
P GeneProduct ncbiprotein:BAB60859.1
IFNA1 GeneProduct ensembl:ENSG00000197919
ADAR GeneProduct ensembl:ENSG00000160710
IL2 GeneProduct ensembl:ENSG00000109471
PIK3CA GeneProduct ensembl:ENSG00000121879
CDK2 GeneProduct ensembl:ENSG00000123374
IL2RA GeneProduct ensembl:ENSG00000134460
IL1A GeneProduct ensembl:ENSG00000115008
IFNA4 GeneProduct ensembl:ENSG00000236637
IL6 GeneProduct ensembl:ENSG00000136244
RACK1 GeneProduct ensembl:ENSG00000204628
HSPA1L GeneProduct ensembl:ENSG00000204390
MAVS GeneProduct ensembl:ENSG00000088888
TLR2 GeneProduct ensembl:ENSG00000137462
SLAMF1 GeneProduct ensembl:ENSG00000117090
MSN GeneProduct ensembl:ENSG00000147065
CLEC4M GeneProduct ensembl:ENSG00000104938
CD209 GeneProduct ensembl:ENSG00000090659
TLR4 GeneProduct ensembl:ENSG00000136869
TRAF6 GeneProduct ncbigene:7189 Original kegg element: gene;53;hsa:7189
TAB2 GeneProduct ncbigene:23118 Original kegg element: gene;61;hsa:23118
IRAK1 GeneProduct ncbigene:3654 Original kegg element: gene;41;hsa:3654
MAP3K7 GeneProduct ncbigene:6885 Original kegg element: gene;37;hsa:6885
IRAK4 GeneProduct ncbigene:51135 Original kegg element: gene;86;hsa:51135
MYD88 GeneProduct ncbigene:4615 Original kegg element: gene;8;hsa:4615
MAPK10 GeneProduct ncbigene:5602 Original kegg element: gene;50;hsa:5599 hsa:5601 hsa:5602
MAPK8 GeneProduct ncbigene:5599 Original kegg element: gene;50;hsa:5599 hsa:5601 hsa:5602
MAPK9 GeneProduct ncbigene:5601 Original kegg element: gene;50;hsa:5599 hsa:5601 hsa:5602
JUN GeneProduct ncbigene:3725 Original kegg element: gene;35;hsa:2353 hsa:3725
FOS GeneProduct ncbigene:2353 Original kegg element: gene;35;hsa:2353 hsa:3725
IL1B GeneProduct ensembl:ENSG00000125538
IL12A GeneProduct ensembl:ENSG00000168811
IL12B GeneProduct ensembl:ENSG00000113302
IFIH1 GeneProduct ensembl:ENSG00000115267
TRAF3 GeneProduct ensembl:ENSG00000131323
TBK1 GeneProduct ncbigene:29110 Original kegg element: gene;52;hsa:29110
IKBKE GeneProduct ncbigene:9641 Original kegg element: gene;54;hsa:9641
C GeneProduct ncbiprotein:BAB60863.1
N GeneProduct ncbiprotein:BAX00474.1
IFNA17 GeneProduct ensembl:ENSG00000234829
IFNA21 GeneProduct ensembl:ENSG00000137080
TLR9 GeneProduct ensembl:ENSG00000239732
CHUK GeneProduct ncbigene:1147 Original kegg element: gene;42;hsa:1147
IKBKG GeneProduct ncbigene:8517 Original kegg element: gene;85;hsa:8517
IKBKB GeneProduct ncbigene:3551 Original kegg element: gene;36;hsa:3551
NFKB1 GeneProduct ncbigene:4790 Original kegg element: gene;10;hsa:4790 hsa:4791 hsa:5970
NFKBIA GeneProduct ncbigene:4792 Original kegg element: gene;64;hsa:4792
RELA GeneProduct ncbigene:5970 Original kegg element: gene;10;hsa:4790 hsa:4791 hsa:5970
NFKB2 GeneProduct ncbigene:4791 Original kegg element: gene;10;hsa:4790 hsa:4791 hsa:5970
IFNAR1 GeneProduct ensembl:ENSG00000142166
IFNAR2 GeneProduct ensembl:ENSG00000159110
TYK2 GeneProduct ensembl:ENSG00000105397
STAT1 GeneProduct ensembl:ENSG00000115415
STAT2 GeneProduct ensembl:ENSG00000170581
OAS2 GeneProduct ensembl:ENSG00000111335
OAS3 GeneProduct ensembl:ENSG00000111331
MX1 GeneProduct ensembl:ENSG00000157601
BAD GeneProduct ensembl:ENSG00000002330
BAX GeneProduct ensembl:ENSG00000087088
BAK1 GeneProduct ensembl:ENSG00000030110
BCL2 GeneProduct ensembl:ENSG00000171791
BCL2L1 GeneProduct ensembl:ENSG00000171552
APAF1 GeneProduct ensembl:ENSG00000120868
CASP9 GeneProduct ensembl:ENSG00000132906
CASP3 GeneProduct ensembl:ENSG00000164305
H GeneProduct ncbiprotein:AAB26146.1
N GeneProduct ncbigene:1489804
P GeneProduct ncbigene:1489805
L GeneProduct ncbigene:1489802
RAB9B GeneProduct ensembl:ENSG00000123570
TP73 GeneProduct ensembl:ENSG00000078900
HSPA1B GeneProduct ensembl:ENSG00000204388
HSPA2 GeneProduct ensembl:ENSG00000126803
CDK4 GeneProduct ensembl:ENSG00000135446
CDK6 GeneProduct ensembl:ENSG00000105810
CCND2 GeneProduct ensembl:ENSG00000118971
CCND3 GeneProduct ensembl:ENSG00000112576
CCNE1 GeneProduct ensembl:ENSG00000105173
CCNE2 GeneProduct ensembl:ENSG00000175305
IL2RB GeneProduct ensembl:ENSG00000100385
IL2RG GeneProduct ensembl:ENSG00000147168
CD3E GeneProduct ensembl:ENSG00000198851
CD3G GeneProduct ensembl:ENSG00000160654
JAK3 GeneProduct ensembl:ENSG00000105639
STAT5A GeneProduct ensembl:ENSG00000126561
STAT5B GeneProduct ensembl:ENSG00000173757
PIK3CB GeneProduct ensembl:ENSG00000051382
PIK3CD GeneProduct ensembl:ENSG00000171608
PIK3R1 GeneProduct ensembl:ENSG00000145675
PIK3R2 GeneProduct ensembl:ENSG00000105647
PIK3R3 GeneProduct ensembl:ENSG00000117461
IKBKG GeneProduct ensembl:ENSG00000269335
IKBKB GeneProduct ensembl:ENSG00000104365
CHUK GeneProduct ensembl:ENSG00000213341
NFKB1 GeneProduct ncbigene:4790
RELA GeneProduct ensembl:ENSG00000173039
NFKBIA GeneProduct ensembl:ENSG00000100906
NFKBIB GeneProduct ensembl:ENSG00000104825
FCGR2B GeneProduct ensembl:ENSG00000072694

References

  1. Viruses, lipid rafts and signal transduction. Rauch S, Fackler OT. Signal Transduction [Internet]. 2007 Feb;7(1):53–63. Available from: http://dx.doi.org/10.1002/sita.200600113 DOI Scholia
  2. KEGG Pathway: hsa05162
  3. Consequences of Fas-mediated human dendritic cell apoptosis induced by measles virus. Servet-Delprat C, Vidalain PO, Azocar O, Le Deist F, Fischer A, Rabourdin-Combe C. J Virol. 2000 May;74(9):4387–93. PubMed Europe PMC Scholia
  4. Measles virus interacts with and alters signal transduction in T-cell lipid rafts. Avota E, Müller N, Klett M, Schneider-Schaulies S. J Virol. 2004 Sep;78(17):9552–9. PubMed Europe PMC Scholia
  5. Nectin 4 is the epithelial cell receptor for measles virus. Noyce RS, Richardson CD. Trends Microbiol. 2012 Sep;20(9):429–39. PubMed Europe PMC Scholia
  6. Measles virus suppresses RIG-I-like receptor activation in dendritic cells via DC-SIGN-mediated inhibition of PP1 phosphatases. Mesman AW, Zijlstra-Willems EM, Kaptein TM, de Swart RL, Davis ME, Ludlow M, et al. Cell Host Microbe. 2014 Jul 9;16(1):31–42. PubMed Europe PMC Scholia