Altered glycosylation of MUC1 in tumor microenvironment (WP4480)
Homo sapiens
Altered MUC1 glycosylation extends to its role as a promoter of chronic inflammatory conditions that lead to malignant transformation and cancer progression.
Authors
Laurent Winckers , Kristina Hanspers , Eric Weitz , and Egon WillighagenActivity
Discuss this pathway
Check for ongoing discussions or start your own.
Cited In
Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.
Organisms
Homo sapiensCommunities
CPTAC PancCanNetAnnotations
Pathway Ontology
disease pathway cancer pathwayCell Type Ontology
T cell dendritic cell macrophageDisease Ontology
cancerLabel | Type | Compact URI | Comment |
---|---|---|---|
IkKB | GeneProduct | ncbigene:8517 | |
TNF | GeneProduct | ncbigene:7124 | |
IkKA | GeneProduct | ncbigene:1147 | |
IkKG | GeneProduct | ncbigene:3551 | |
IkBA | GeneProduct | ncbigene:4792 | |
RELA | GeneProduct | ncbigene:5970 | |
IL6 | GeneProduct | ncbigene:3569 | |
MUC1 | GeneProduct | ncbigene:4582 | |
NFKB1 | GeneProduct | ncbigene:4790 |
References
- Introduction to NF-kappaB: players, pathways, perspectives. Gilmore TD. Oncogene. 2006 Oct 30;25(51):6680–4. PubMed Europe PMC Scholia
- Intra- and Extra-Cellular Events Related to Altered Glycosylation of MUC1 Promote Chronic Inflammation, Tumor Progression, Invasion, and Metastasis. Cascio S, Finn OJ. Biomolecules. 2016 Oct 13;6(4):39. PubMed Europe PMC Scholia