Vitamins A and D - action mechanisms (WP4342)

Homo sapiens

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The active forms of vitamins A and D both activate nuclear receptors. The generation of the vitamin metabolites and their role in the activation of the nuclear receptors is shown in the pathway.

Authors

Susan Coort , Kristina Hanspers , Alex Pico , and Eric Weitz

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Cell Type Ontology

kidney cell hepatocyte

Pathway Ontology

vitamin A and metabolites signaling pathway vitamin D signaling pathway vitamin D metabolic pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
Beta-carotene Metabolite chebi:17579
7-Dehydrocholesterol Metabolite hmdb:HMDB0000032
Retinol (vit A) Metabolite chebi:17336
Retinal Metabolite chebi:15035
ATRA Metabolite chebi:50648
9-cis-Retinoic acid Metabolite hmdb:HMDB0002369
25(OH)D3 Metabolite chebi:17933
Vitamin D3 Metabolite chebi:28940
Previtamin D3 Metabolite hmdb:HMDB0006500
1,25(OH)2D3 Metabolite hmdb:HMDB0000969
VDR GeneProduct ensembl:ENSG00000111424
RXR GeneProduct ensembl:ENSG00000186350
RXR GeneProduct ensembl:ENSG00000131759
RAR GeneProduct ensembl:ENSG00000131759

References

  1. Vitamin effects on the immune system: vitamins A and D take centre stage. Mora JR, Iwata M, von Andrian UH. Nat Rev Immunol. 2008 Sep;8(9):685–98. PubMed Europe PMC Scholia