Non-genomic actions of 1,25-dihydroxyvitamin D3 (WP4341)

Homo sapiens

The pathway summarizes non-genomic actions of the hormonally active form of vitamin D: 1,25-dihydroxyvitamin D3. It is based the pathway figure published by Hii and Ferrante (Nutrients, 2016).

Authors

Susan Coort , Denise Slenter , Eric Weitz , and Egon Willighagen

Activity

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

vitamin D signaling pathway signaling pathway

Participants

Label Type Compact URI Comment
PMA Metabolite chebi:37537
1,25D Metabolite hmdb:HMDB0001903
DAG Metabolite lipidmaps:LMGL0201
25D Metabolite hmdb:HMDB0003550
AA Metabolite hmdb:HMDB0001043
CaMK2A GeneProduct ensembl:ENSG00000070808
CaMK2B GeneProduct ensembl:ENSG00000058404
CaMK2G GeneProduct ensembl:ENSG00000148660
PLCB1 GeneProduct ensembl:ENSG00000182621
PLCB2 GeneProduct ensembl:ENSG00000137841
PLCB3 GeneProduct ensembl:ENSG00000149782
PLCB4 GeneProduct ensembl:ENSG00000101333
PLCG1 GeneProduct ensembl:ENSG00000187091
PLCD1 GeneProduct ensembl:ENSG00000187091
PLCD3 GeneProduct ensembl:ENSG00000187091
PLCD4 GeneProduct ensembl:ENSG00000187091
PLCE1 GeneProduct ensembl:ENSG00000138193
TLR2 GeneProduct ensembl:ENSG00000137462
TLR8 GeneProduct ensembl:ENSG00000101916
PRKCE GeneProduct ensembl:ENSG00000171132
PRKCH GeneProduct ensembl:ENSG00000027075
PRKCQ GeneProduct ensembl:ENSG00000065675
PIK3CA GeneProduct insdc:ENSG00000121879
PIK3CB GeneProduct insdc:ENSG00000051382
PIK3CG GeneProduct insdc:ENSG00000105851
PIK3CD GeneProduct insdc:ENSG00000171608
PIK3R1 GeneProduct insdc:ENSG00000145675
PIK3R3 GeneProduct insdc:ENSG00000117461
PIK3R4 GeneProduct insdc:ENSG00000196455
PIK3R5 GeneProduct insdc:ENSG00000141506
PIK3C2A GeneProduct insdc:ENSG00000011405
PIK3C2B GeneProduct insdc:ENSG00000133056
PIK3C2G GeneProduct insdc:ENSG00000139144 
AKT1 GeneProduct insdc:ENSG00000142208
AKT2 GeneProduct insdc:ENSG00000105221
AKT3 GeneProduct insdc:ENSG00000117020
RXRB GeneProduct ensembl:ENSG00000204231
STAT1 GeneProduct ensembl:ENSG00000115415
STAT2 GeneProduct ensembl:ENSG00000170581
JAK1 GeneProduct ensembl:ENSG00000162434
IFI44L GeneProduct ensembl:ENSG00000137959
ISG15 GeneProduct ensembl:ENSG00000187608
OAS1 GeneProduct ensembl:ENSG00000089127 
OAS2 GeneProduct ensembl:ENSG00000111335
OAS3 GeneProduct ensembl:ENSG00000111331 
RSAD2 GeneProduct ensembl:ENSG00000134321
IKK2 GeneProduct ensembl:ENSG00000104365
PIK3R2 GeneProduct insdc:ENSG00000105647
MED1 GeneProduct ensembl:ENSG00000125686
PLA2 GeneProduct interpro:IPR001211 Enzyme family, EC 3.1.1.4 [https://en.wikipedia.org/wiki/Phospholipase_A2]
PLCG2 GeneProduct ensembl:ENSG00000197943
IFI27L GeneProduct ensembl:ENSG00000119632
PIK3C3 GeneProduct insdc:ENSG00000078142 
CYP27B1 GeneProduct ensembl:ENSG00000111012
SP3 GeneProduct ensembl:ENSG00000172845
PRKCG GeneProduct ensembl:ENSG00000126583
PRKCB GeneProduct ensembl:ENSG00000166501
PRKCA GeneProduct ensembl:ENSG00000154229
RXRG GeneProduct ensembl:ENSG00000143171
CD40LG GeneProduct ensembl:ENSG00000102245
PRKCD GeneProduct ensembl:ENSG00000163932
VDR GeneProduct ensembl:ENSG00000111424
RXRA GeneProduct ensembl:ENSG00000186350
CaMK2D GeneProduct ensembl:ENSG00000145349
ETS1 GeneProduct ensembl:ENSG00000134954
TLR4 GeneProduct ensembl:ENSG00000136869
VDRn GeneProduct ensembl:ENSG00000111424
CD40 GeneProduct ensembl:ENSG00000101017
TYK2 GeneProduct ensembl:ENSG00000105397
VDRm/n GeneProduct ensembl:ENSG00000111424
SP1 GeneProduct ensembl:ENSG00000185591
cJUN GeneProduct ensembl:ENSG00000177606
KRAS GeneProduct ensembl:ENSG00000133703
HRAS GeneProduct ensembl:ENSG00000174775
NRAS GeneProduct ensembl:ENSG00000213281
MAPK3 GeneProduct ensembl:ENSG00000102882
MAPK1 GeneProduct ensembl:ENSG00000100030
MAPK7 GeneProduct ensembl:ENSG00000166484
MAPK8 GeneProduct ensembl:ENSG00000107643
MAPK9 GeneProduct ensembl:ENSG00000050748
PKC zeta GeneProduct ensembl:ENSG00000067606
NFKB1 GeneProduct ensembl:ENSG00000109320
RELB GeneProduct ensembl:ENSG00000104856
NFKB2 GeneProduct ensembl:ENSG00000077150
TNFR1 GeneProduct ensembl:ENSG00000067182
TNF GeneProduct ensembl:ENSG00000232810
MAPK11 GeneProduct ensembl:ENSG00000185386
MAPK14 GeneProduct ensembl:ENSG00000112062
MAPK13 GeneProduct ensembl:ENSG00000156711
MAPK12 GeneProduct ensembl:ENSG00000188130
CYP24A1 GeneProduct ensembl:ENSG00000019186
CAMP GeneProduct ensembl:ENSG00000164047
DEFB4A GeneProduct ensembl:ENSG00000171711
NOD2 GeneProduct ensembl:ENSG00000167207
CCL2 GeneProduct ensembl:ENSG00000108691
CXCL8 GeneProduct ensembl:ENSG00000169429
IL-6 GeneProduct ensembl:ENSG00000136244
Caveolin-1 Protein uniprot:Q03135
IFNR gamma 1 Protein uniprot:P15260 The IFN-γ receptor (IFNGR) is a heterodimeric receptor composed of the IFNGR-1 (α chain) and IFNGR-2 (β chain) chains
IFN gamma Protein uniprot:P01579
IFN alpha Protein uniprot:P01563
IFNR alpha Protein uniprot:P48551 AKA interferon-α/β receptor (IFNAR)
IFNR gamma 2 Protein uniprot:P38484 The IFN-γ receptor (IFNGR) is a heterodimeric receptor composed of the IFNGR-1 (α chain) and IFNGR-2 (β chain) chains

References

  1. The Non-Genomic Actions of Vitamin D. Hii CS, Ferrante A. Nutrients. 2016 Mar 2;8(3):135. PubMed Europe PMC Scholia