miRNA role in immune response in sepsis (WP4329)

Homo sapiens

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Involvement of cellular miRNAs in the signaling pathway of the immune response in sepsis. Cellular immune miRNAs target important components of the NF-κB signaling pathway at different levels regulating the inflammatory response in the pathogenesis of sepsis. Lower part of the figure illustrates the pathophysiological events in sepsis that lead to tissue injury and subsequent multiple organs failure.

Authors

Kristina Hanspers , Egon Willighagen , and Eric Weitz

Activity

last edited

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Organisms

Homo sapiens

Communities

ExRNA

Annotations

Pathway Ontology

nuclear factor kappa B signaling pathway immune response pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
LPS Metabolite chebi:16412
TLR4 GeneProduct ensembl:ENSG00000136869
TLR7 GeneProduct ensembl:ENSG00000196664
MAP3K7 GeneProduct ensembl:ENSG00000135341
IRAK1 GeneProduct ensembl:ENSG00000184216
IL1A GeneProduct ensembl:ENSG00000115008
MYD88 GeneProduct ensembl:ENSG00000172936
ICAM1 GeneProduct ensembl:ENSG00000090339
MIRLET7I GeneProduct ensembl:ENSG00000199179
MIR146B GeneProduct ensembl:ENSG00000202569
MIR223 GeneProduct ensembl:ENSG00000274536
IRAK4 GeneProduct ensembl:ENSG00000198001
TRAF6 GeneProduct ensembl:ENSG00000175104
TAB2 GeneProduct ensembl:ENSG00000055208
TAB1 GeneProduct ensembl:ENSG00000100324
MIR155HG GeneProduct ensembl:ENSG00000234883
IKBKG GeneProduct ensembl:ENSG00000269335
CHUK GeneProduct ensembl:ENSG00000213341
IKBKB GeneProduct ensembl:ENSG00000104365
MIR16-1 GeneProduct ensembl:ENSG00000208006
MIR16-2 GeneProduct ensembl:ENSG00000198987
MIR199A1 GeneProduct ensembl:ENSG00000207752
MIR199A2 GeneProduct ensembl:ENSG00000208024
MIR126 GeneProduct ensembl:ENSG00000199161
MIR9-1 GeneProduct ensembl:ENSG00000207933
TRAF3 GeneProduct ensembl:ENSG00000131323
TLR8 GeneProduct ensembl:ENSG00000101916
MIR149 GeneProduct ensembl:ENSG00000207611
MIR200B GeneProduct ensembl:ENSG00000207730
MIR200C GeneProduct ensembl:ENSG00000207713
MIR203A GeneProduct ensembl:ENSG00000207568
MIR203B GeneProduct ensembl:ENSG00000283165
MIR758 GeneProduct ensembl:ENSG00000211582
MAPK14 GeneProduct ensembl:ENSG00000112062
MAPK8 GeneProduct ensembl:ENSG00000107643
IRF5 GeneProduct ensembl:ENSG00000128604
IRF1 GeneProduct ensembl:ENSG00000125347
IRF7 GeneProduct ensembl:ENSG00000185507
IkB GeneProduct uniprot:P25963 IkB Not Specified
RELA GeneProduct ncbigene:5970
NFKB2 GeneProduct ensembl:ENSG00000077150
RELB GeneProduct ncbigene:5971
c-REL GeneProduct ncbigene:5966
NFKB1 GeneProduct ensembl:ENSG00000109320
CXCL8 GeneProduct ensembl:ENSG00000169429
CCL3 GeneProduct ensembl:ENSG00000277632
CCL4 GeneProduct ensembl:ENSG00000275302
VCAM1 GeneProduct ensembl:ENSG00000162692
ELANE GeneProduct ensembl:ENSG00000197561
LCN2 GeneProduct ensembl:ENSG00000148346
GZMB GeneProduct ensembl:ENSG00000100453
IL6 GeneProduct ensembl:ENSG00000136244
MIR21 GeneProduct ensembl:ENSG00000284190
MIR29A GeneProduct hgnc.symbol:MIR29A
MIR145 GeneProduct ensembl:ENSG00000276365
MIR155 GeneProduct ensembl:ENSG00000283904
TNF GeneProduct ensembl:ENSG00000232810
IL10 GeneProduct ensembl:ENSG00000136634
MIR106A GeneProduct ensembl:ENSG00000284157
MIR106B GeneProduct ensembl:ENSG00000208036
MIR4461 GeneProduct ensembl:ENSG00000263963
MIR19A GeneProduct ensembl:ENSG00000284204
MIR125B1 GeneProduct ensembl:ENSG00000207971
MIR125B2 GeneProduct ensembl:ENSG00000207863
MIR187 GeneProduct ensembl:ENSG00000207797
MIR122 GeneProduct ensembl:ENSG00000284440

References

  1. Cellular and viral microRNAs in sepsis: mechanisms of action and clinical applications. Giza DE, Fuentes-Mattei E, Bullock MD, Tudor S, Goblirsch MJ, Fabbri M, et al. Cell Death Differ. 2016 Dec;23(12):1906–18. PubMed Europe PMC Scholia