Mevalonate arm of cholesterol biosynthesis pathway with inhibitors (WP4189)
Homo sapiens
An analysis of the mevalonate branch of the cholesterol biosynthesis pathway, and a set of inhibitors directed against targets in this pathway. Inhibitors which have been found for Homo Sapiens are coloured red, those found for Rattus norvegicus orange. View more details on where these reactions in the cell take place at [https://www.wikipathways.org/index.php/Pathway:WP4190]. View the broader scope of cholesterol metabolism at [https://www.wikipathways.org/index.php/Pathway:WP430].
Authors
Denise Slenter , Egon Willighagen , and Jesse VercoulenActivity
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Organisms
Homo sapiensCommunities
Annotations
Pathway Ontology
cholesterol biosynthetic pathway altered cholesterol biosynthetic pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| (+)-Zaragozic acid | Metabolite | chebi:83934 | |
| dimethylallyl-PP | Metabolite | wikidata:Q417398 | |
| 6-fluoromevalonate 5-diphosphate | Metabolite | wikidata:Q27074009 | |
| L-659699 | Metabolite | pubchem.compound:6440895 | Only found for Rattus norvegicus. L-659699 is a.k.a. (E,E)-11-[3-(hydroxymethyl)-4-oxo-2-oxytanyl]-3,5,7-trimethyl-2,4-undecadienenoic acid |
| rosuvastatin | Metabolite | wikidata:Q415159 | |
| Cinnamic acid | Metabolite | hmdb:HMDB0000567 | Only found for Rattus norvegicus. |
| 2-fluoromevalonate 5-diphosphate | Metabolite | wikidata:Q27071897 | Only found for Rattus norvegicus. |
| Acetyl-CoA | Metabolite | chebi:15351 | |
| zoledronic acid | Metabolite | wikidata:Q28852343 | |
| BPH-628 | Metabolite | wikidata:Q27075447 | |
| 3-hydroxy-3-methylglutaryl-CoA | Metabolite | wikidata:Q27108899 | |
| acetoacetyl-CoA | Metabolite | wikidata:Q2639429 | |
| farnesyl thiodiphosphate | Metabolite | wikidata:Q27077283 | |
| mevalonate | Metabolite | wikidata:Q27109878 | |
| mevalonate-P | Metabolite | wikidata:Q27464491 | |
| mevalonate-PP | Metabolite | wikidata:Q45415198 | |
| isopenthyl-PP | Metabolite | wikidata:Q417403 | |
| geranyl-PP | Metabolite | wikidata:Q418125 | |
| famesyl-PP | Metabolite | wikidata:Q2699676 | |
| geranylgeranyl-PP | Metabolite | wikidata:Q774795 | |
| presqualene-PP | Metabolite | wikidata:Q27088444 | |
| squalene | Metabolite | wikidata:Q407560 | |
| cerivastatin | Metabolite | wikidata:Q423439 | |
| atorvastatin | Metabolite | wikidata:Q668093 | |
| lovastatin | Metabolite | wikidata:Q417740 | |
| simvastatin | Metabolite | wikidata:Q670131 | |
| CHEMBL39312 | Metabolite | chembl.compound:CHEMBL39312 | |
| CHEMBL39102 | Metabolite | chembl.compound:CHEMBL39102 | |
| Fluvastatin | Metabolite | wikidata:Q417942 | |
| 3-hydroxy-3-methyl-6-phosphohexanoic acid | Metabolite | wikidata:Q27073729 | Only found for Rattus norvegicus. |
| isoferulic acid | Metabolite | wikidata:Q27096447 | Only found for Rattus norvegicus. |
| p-coumaric acid | Metabolite | wikidata:Q99374 | Only found for Rattus norvegicus. |
| diphosphoglycolyl proline | Metabolite | wikidata:Q27077077 | |
| CHEMBL1160330 | Metabolite | chembl.compound:CHEMBL1160330 | |
| CHEMBL1160328 | Metabolite | chembl.compound:CHEMBL1160328 | |
| P'-geranyl 2-fluoromevalonate 5-diphosphate | Metabolite | wikidata:Q27088347 | |
| P'-geranyl 3,5,9-trihydroxy-3-methylnonanate 9-diphosphate | Metabolite | pubchem.compound:11650985 | Only found for Rattus norvegicus. |
| NE97220 | Metabolite | wikidata:Q27087890 | |
| Risedronate | Metabolite | hmdb:HMDB0015022 | |
| NE58062 | Metabolite | wikidata:Q27087889 | |
| NE58018 | Metabolite | pubchem.compound:405372 | |
| BPH-608 | Metabolite | wikidata:Q27075443 | |
| BPH-675 | Metabolite | wikidata:Q27075451 | |
| BPH-629 | Metabolite | wikidata:Q27075449 | |
| BPH-676 | Metabolite | wikidata:Q27075453 | |
| BPH-830 | Metabolite | wikidata:Q27075459 | |
| CHEMBL24362 | Metabolite | chembl.compound:CHEMBL24362 | |
| sq-109 | Metabolite | wikidata:Q7392720 | |
| CHEMBL1208103 | Metabolite | chembl.compound:CHEMBL1208103 | |
| [1-(Hydroxycarbamoyl)-4-(3-phenoxyphenyl)butyl]phosphonate | Metabolite | pubchem.compound:44185382 | |
| CHEMBL1207858 | Metabolite | chembl.compound:CHEMBL1207858 | |
| Compound 13 | Metabolite | pubchem.compound:44185378 | PMID: 19456099 |
| (1-Methyl-1-{[3-(3-phenoxyphenyl)propyl]carbamoyl}ethyl)phosphonate | Metabolite | pubchem.compound:44185378 | |
| FDFT1 | Protein | wikidata:Q21108578 | |
| HMGCS1 | Protein | wikidata:Q21118293 | |
| HMGCR | Protein | uniprot:P04035 | |
| IDI1 | Protein | wikidata:Q21151146 | |
| MVK | Protein | wikidata:Q424031 | |
| FDPS | Protein | wikidata:Q21107439 | |
| PMVK | Protein | wikidata:Q22676988 | |
| MVD | Protein | uniprot:P53602 | |
| GGPS1 | Protein | wikidata:Q21106540 | |
| IDI2 | Protein | wikidata:Q21132842 |
References
- Antidepressant drugs affect dopamine uptake. Halaris AE, Belendiuk KT, Freedman DX. Biochem Pharmacol. 1975 Oct 15;24(20):1896–7. PubMed Europe PMC Scholia
- Inhibition of hydroxymethylglutaryl-coenzyme A synthase by L-659,699. Greenspan MD, Yudkovitz JB, Lo CY, Chen JS, Alberts AW, Hunt VM, et al. Proc Natl Acad Sci U S A. 1987 Nov;84(21):7488–92. PubMed Europe PMC Scholia
- The increasingly complex mechanism of HMG-CoA reductase. Haines BE, Wiest O, Stauffacher CV. Acc Chem Res. 2013 Nov 19;46(11):2416–26. PubMed Europe PMC Scholia
- Is systems pharmacology ready to impact upon therapy development? A study on the cholesterol biosynthesis pathway. Benson HE, Watterson S, Sharman JL, Mpamhanga CP, Parton A, Southan C, et al. Br J Pharmacol. 2017 Dec;174(23):4362–82. PubMed Europe PMC Scholia