Lipid droplet metabolism (WP3901)

Rattus norvegicus

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Lipid droplets are cytosolic organelles present in nearly all cell types. Initially they were considered only as inert lipid-storage sites, but now they are recognized to be involved in other functions and even associated with liver and kidney disease. Still, the mechanisms for lipid accumulation into the lipid droplet are not totally understood. Even though the lipid and protein composition of the lipid droplets is highly dynamic, triglycerides and cholesterol esters are the main components of them. This pathway features the basic enzymatic steps necessary to esterify glycerol and cholesterol.

Authors

Agustin Gonzalez-Vicente , Egon Willighagen , Alex Pico , and Eric Weitz

Activity

last edited

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Organisms

Rattus norvegicus

Communities

Renal Genomics Pathways

Annotations

Disease Ontology

lipid metabolism disorder neutral lipid storage disease

Pathway Ontology

lipid metabolic pathway

Participants

Label Type Compact URI Comment
Fatty Acids Metabolite chebi:35366
Acyl-CoA Metabolite chebi:58342
Cholesterol Metabolite hmdb:HMDB0000067
PhosphatidicAcid Metabolite chebi:16337
Glycerol Metabolite hmdb:HMDB0000131
Triglycerides Metabolite chebi:17855
Cholesterol Esters Metabolite chebi:17002
Glycerol-3-P Metabolite hmdb:HMDB0000126
DHA-P Metabolite hmdb:HMDB0001473
Plin2 GeneProduct ncbigene:298199
Aup1 GeneProduct ncbigene:680423
Acsl1 GeneProduct ncbigene:25288
Bscl2 GeneProduct ncbigene:361722
Fitm2 GeneProduct ncbigene:311617
Acsl3 GeneProduct ncbigene:114024
Acsl4 GeneProduct ncbigene:113976
Pnpla2 GeneProduct ncbigene:361676
Dgat1 GeneProduct ncbigene:84497
Dgat2 GeneProduct ncbigene:252900
Soat1 GeneProduct ncbigene:81782
Soat2 GeneProduct ncbigene:266770
Lipa GeneProduct ncbigene:25055
Gk GeneProduct ncbigene:79223
Gpat2 GeneProduct ncbigene:296130
Agpat3 GeneProduct ncbigene:294324
Agpat1 GeneProduct ncbigene:406165
Agpat4 GeneProduct ncbigene:170919
Agpat2 GeneProduct ncbigene:311821
Agpat5 GeneProduct ncbigene:306582
Lpin1 GeneProduct ncbigene:313977
Lpin2 GeneProduct ncbigene:316737
Lpin3 GeneProduct ncbigene:362261
Gpd1 GeneProduct ncbigene:60666
Gpd2 GeneProduct ncbigene:25062

References

  1. Review: biogenesis of the multifunctional lipid droplet: lipids, proteins, and sites. Pol A, Gross SP, Parton RG. J Cell Biol. 2014 Mar 3;204(5):635–46. PubMed Europe PMC Scholia