ERK pathway in Huntington's disease (WP3853)
Homo sapiens
This ERK pathway is implicated in Huntington's disease. The ligands BDNF, EGF, and Glu bind to their respective receptors (TrkB, EGFR, mGluR) and start a signal transduction pathway starting with RAS and RAF1, which leads to the stimulation of MEK then ERK. ERK promotes function of MSK1 (a downstream kinase), ElK1 and CREB (transcription factors), and caspases 3/7 (apoptotic molecules). These downstream targets are implicated in producing the effects of Huntington's disease at the cellular level. This pathway is based on Figure 1 from Bodai et al. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP3853 CPTAC Assay Portal]
Authors
AAR&Co , Martina Summer-Kutmon , Kristina Hanspers , Andika Tan , Nirupama Benis , Eric Weitz , and Aishwarya IyerActivity
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Organisms
Homo sapiensCommunities
Diseases Rare DiseasesAnnotations
Pathway Ontology
signaling pathway disease pathway Huntington's disease pathwayDisease Ontology
Huntington's diseaseLabel | Type | Compact URI | Comment |
---|---|---|---|
Glutamate | Metabolite | hmdb:HMDB0000148 | |
CREB | GeneProduct | ensembl:ENSG00000118260 | |
CASP7 | GeneProduct | ensembl:ENSG00000165806 | |
RAS | GeneProduct | ensembl:ENSG00000174775 | |
CASP3 | GeneProduct | ensembl:ENSG00000164305 | |
NTRK2 | GeneProduct | ensembl:ENSG00000148053 | |
MSK1 | GeneProduct | ensembl:ENSG00000100784 | |
GRM1 | GeneProduct | ensembl:ENSG00000152822 | |
ELK1 | GeneProduct | ensembl:ENSG00000126767 | |
MAPK1 | GeneProduct | ensembl:ENSG00000100030 | |
BDNF | GeneProduct | ensembl:ENSG00000176697 | |
HTT | GeneProduct | ensembl:ENSG00000197386 | mutant Huntingtin |
EGF | GeneProduct | ensembl:ENSG00000138798 | |
EGFR | GeneProduct | ensembl:ENSG00000146648 | |
RAF1 | GeneProduct | ensembl:ENSG00000132155 | |
MAP2K1 | GeneProduct | hgnc.symbol:MAP2K1 | |
MAP2K2 | GeneProduct | hgnc.symbol:MAP2K2 | |
MAPK3 | GeneProduct | hgnc.symbol:MAPK3 |
References
- A novel target for Huntington’s disease: ERK at the crossroads of signaling. The ERK signaling pathway is implicated in Huntington’s disease and its upregulation ameliorates pathology. Bodai L, Marsh JL. Bioessays. 2012 Feb;34(2):142–8. PubMed Europe PMC Scholia