Interleukin-1 induced activation of NF-kB (WP3656)

Homo sapiens

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Interleukin-1 Induced activation of NF-kB through the phosphorylated TRAF6/Ajuba/PKCz/SQST1 complex. The pathway is defined by multiple binding steps to the TRAF6/Ajuba/PKCz/SQST1 complex. The small arrows constitute a earlier binding. After binding occurs the complex is phosphorylated and activates NF-kB. This pathway is based on figure 6 from Li et al.

Authors

AAR&Co , Jonathan Mélius , Kristina Hanspers , Egon Willighagen , and Eric Weitz

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

signaling pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
ATP Metabolite hmdb:HMDB0000538
ADP Metabolite hmdb:HMDB0001341
AJUBA GeneProduct ensembl:ENSG00000129474
PKCZ GeneProduct ensembl:ENSG00000067606
IL-1 GeneProduct ensembl:ENSG00000115008
SQSTM1 GeneProduct ensembl:ENSG00000161011
NF-KB GeneProduct uniprot:P19838
TRAF6 GeneProduct ensembl:ENSG00000175104
TIFA GeneProduct ensembl:ENSG00000145365
UEV1A GeneProduct ensembl:ENSG00000244687
UBC13 GeneProduct ensembl:ENSG00000177889
IRAK1 GeneProduct ensembl:ENSG00000184216

References

  1. Identification of potential pathway mediation targets in Toll-like receptor signaling. Li F, Thiele I, Jamshidi N, Palsson BØ. PLoS Comput Biol. 2009 Feb;5(2):e1000292. PubMed Europe PMC Scholia