Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling (WP3612)

Homo sapiens

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Photodynamic therapy may induce an antioxidant response mediated by NFE2L2. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP3612 CPTAC Assay Portal]

Authors

Ruud Weijer , Kristina Hanspers , Friederike Ehrhart , Alex Pico , and Eric Weitz

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

altered regulatory pathway

Disease Ontology

cancer

Participants
Query Drugst.One

Label Type Compact URI Comment
GCLM GeneProduct ncbigene:2730
GCLC GeneProduct ncbigene:2729
GSTP1 GeneProduct ncbigene:2950
JUN GeneProduct ncbigene:3725
ABCG2 GeneProduct ncbigene:9429
FOS GeneProduct ncbigene:2353
ABCC3 GeneProduct ncbigene:8714
ABCC2 GeneProduct ncbigene:1244
KEAP1 GeneProduct ncbigene:9817
ABCC4 GeneProduct ncbigene:10257
ABCC6 GeneProduct ncbigene:368
HMOX1 GeneProduct ncbigene:3162
MAPK12 GeneProduct ncbigene:6300
MAPK13 GeneProduct ncbigene:5603
MAPK11 GeneProduct ncbigene:5600
NFE2L2 GeneProduct ncbigene:4780
MAPK14 GeneProduct ncbigene:1432
MAPK8 GeneProduct ncbigene:5599
EPHX1 GeneProduct ncbigene:2052
CES1 GeneProduct ncbigene:1066
NQO2 GeneProduct ncbigene:4835
SRXN1 GeneProduct ncbigene:140809
NQO1 GeneProduct ncbigene:1728

References

  1. Tumor cell survival pathways activated by photodynamic therapy: a molecular basis for pharmacological inhibition strategies. Broekgaarden M, Weijer R, van Gulik TM, Hamblin MR, Heger M. Cancer Metastasis Rev. 2015 Dec;34(4):643–90. PubMed Europe PMC Scholia
  2. Low-power photodynamic therapy induces survival signaling in perihilar cholangiocarcinoma cells. Weijer R, Broekgaarden M, van Golen RF, Bulle E, Nieuwenhuis E, Jongejan A, et al. BMC Cancer. 2015 Dec 26;15:1014. PubMed Europe PMC Scholia