eIF5A regulation in response to inhibition of the nuclear export system (WP3302)

Homo sapiens

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Model of eIF5A regulation in response to inhibition of the nuclear export system. Under normal conditions, IGF2BP1 is exported by XPO1 and binds to eIF5A in cytoplasm. The binding with IGF2BP1 prevents eIF5A from accumulating in mitochondria. SINE (Selective Inhibitors of Nuclear Export) inhibits the nuclear export of IGF2BP1, resulting in decreased cytoplasmic IGF2BP1. Unbound eIF5A accumulates in mitochondria and induces apoptosis.

Authors

Kristina Hanspers , Alex Pico , Susan Coort , and Egon Willighagen

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

ExRNA

Annotations

Pathway Ontology

nuclear protein transport pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
EIF5A GeneProduct ensembl:ENSG00000132507
EXP4 GeneProduct ensembl:ENSG00000132953
IGF2BP1 GeneProduct ensembl:ENSG00000159217
CRM1 GeneProduct ensembl:ENSG00000082898

References

  1. XPO1/CRM1 Inhibition Causes Antitumor Effects by Mitochondrial Accumulation of eIF5A. Miyake T, Pradeep S, Wu SY, Rupaimoole R, Zand B, Wen Y, et al. Clin Cancer Res. 2015 Jul 15;21(14):3286–97. PubMed Europe PMC Scholia