Glycerophospholipid biosynthetic pathway (WP2533)

Homo sapiens

Open in new tab Open in NDEx Open in Newt (SBGN)
Download PNG Download SVG Download JSON Download GPML Learn more about Downloads
Glycerophospholipids or phosphoglycerides, in which the hydrophobic regions are composed of two fatty acids joined to glycerol; and sphingolipids, in which a single fatty acid is joined to a fatty amine, sphingosine, are glycerol-based phospholipids and the main component of biological membranes. The hydrophilic moieties in these amphipathic compounds may be as a simple as a single -OH at one end of the sterol ring system, or they may be more complex. Glycerophospholipds, as well as sphingolipids, contained polar or charged alcohols at their polar ends; some also contain phosphate groups. In glycerophospholipids, two fatty acids are ester-linked to glycerol at C-1 and C-2, and a highly polar or charged (and therefore hydrophilic) head group is attached to C-3 through a phosphodiester bond. All glycerophospholipds are derivatives of phosphatidic acid and are named for their polar head groups (e.g., phosphatidylethanolamine and phosphatidylcholine). All have a negative charge on the phosphate group at pH 7.0. The head-goup alcohol may also contribute one or more charges at pH near 7.0. The fatty acids in glycerophospholipds can be any of a wide variety. They are different in different species, in different tissues of the same species, and in different types of glycerophospholipids in the same cell or tissue. In general, glycerophospholipids contain a saturated fatty acid at C-1 and an unsaturated fatty acid at C-2, and, in general terms, the fatty acyl groups are generally 16 or 18 carbons long. Eukaryotic membranes contain significant amounts of two other types of glycerophospholipids: Plasmalogens and Alkylacylglycerophospholipids. Plasmalogens contain a hydrocarbon chain linked to glycerol C-1 via vinyl ether linkage whereas alkylacylglycerophospholipids the alkyl substituent at glycerol C-1 is attached via an ether linkage. About 20% of mammalian glycerophospholipids are plasmalogens, this percentage varies both from species to species and from tissue to tissue within a given organism. While plasmalogens comprise only about 0.8% of the phospholipids in human liver, they account for around 23% of those in human nervous tissue. The alkylacylglycerophospholipids are less abundant than the plasmalogens, e.g., about 59% of ethanolamine glycerophospholipids of human heart are plasmalogens, whereas only 3.6% are alkylacylglycerophospholipids. However, in bovine erythrocytes, 75% of the ethanolamine glycerophospholipids are of alkylacyl type.

Authors

Arturo Manzo-Fontes P D , Martina Summer-Kutmon , Egon Willighagen , Denise Slenter , Elisa Cirillo , Lauren J. Dupuis , Eric Weitz , Conroy lipids , and Kristina Hanspers

Activity

last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.

Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

phosphatidylcholine metabolic pathway glycerophospholipid metabolic pathway phosphoinositide metabolic pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
Shark liver oil Metabolite wikidata:Q4380845
1-Alkenyl-2-acyl-glycerophosphocholine Metabolite chebi:17810 (Plasmenylcholine)
1-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine Metabolite chebi:36712 (Plasmanylethanolamine)
1-Alkyl-sn-glycerol 3-phosphate Metabolite chebi:17106
1-alkyl-2-acyl-sn-glycero-3-phosphocholine(Plasmanylcholine) Metabolite chebi:36702
1-alkyl-2-acyl-sn-glycerol 3-phosphate(Plasmanic acid) Metabolite chebi:37296
1-alkenyl-2-acylglycero-phosphoethanolamine Metabolite chebi:17476 (Plasmenylethanolamine)
1-alkyl-2-acyl-sn-glycerol Metabolite pubchem.compound:17756737
NADPH + H+ Metabolite pubchem.compound:5884
NADP(Coenzyme II) Metabolite pubchem.compound:5886
Acyl-CoA Metabolite chebi:17984
CoA-SH Metabolite pubchem.compound:6816
Pi Metabolite pubchem.substance:1061
Cytidine diphosphate ethanolamine(CDP-ethanolamine) Metabolite pubchem.compound:123727
CMP Metabolite pubchem.compound:6131
2H2O Metabolite chebi:16240
CDP-choline Metabolite chebi:49086
Choline Metabolite pubchem.compound:305
Ethanolamine Metabolite pubchem.compound:700
1-Alkyl-2-acetyl-sn-glycerol 3-phosphate Metabolite chebi:17555
H2O Metabolite chebi:15377
Acetyl-CoA Metabolite pubchem.compound:444493
1-Alkyl-2-acetyl-sn-glycerol Metabolite chebi:16291
1-alkyl-2-acetyl-sn-glycero-3-phosphocholine(Platelet Activating Factor, PAF) Metabolite chebi:36707
S-Adenosylmethionine(AdoMet) Metabolite pubchem.compound:34756
S-Adenosylhomocysteine(AdoHcy) Metabolite pubchem.compound:439155
Ethanolamine phosphate Metabolite pubchem.compound:1015
CDP-ethanolamine Metabolite pubchem.compound:123727
1-alkyl-sn-glycero-3-phosphocholine(Lyso PAF) Metabolite chebi:36702
1-Alkyl-sn-glycerol Metabolite chebi:15850
ATP Metabolite pubchem.compound:5957
ADP Metabolite pubchem.compound:6022
triacyl-sn-glycerol(Triacylglycerol; TAG) Metabolite lipidmaps:LMGL03010000
Adenosine triphosphate(ATP) Metabolite pubchem.compound:5957
sn-glycerol-3-phosphate(glycerol-3-P) Metabolite pubchem.compound:7048686
1,2-diacyl-sn-glycero-3-phosphate(Phosphatidic acid; PA) Metabolite lipidmaps:LMGP10010000
PPi Metabolite chebi:45212
NAD+(Coenzyme I) Metabolite pubchem.compound:5892
Fatty acyl-CoA Metabolite lipidmaps:LMFA07050000
Dihydroxyacetone phosphate Metabolite pubchem.compound:668
1,2-diacyl-sn-glycerol(1,2-diacylglycerol; 1,2-DAG) Metabolite lipidmaps:LMGL02010000
Glycerol Metabolite pubchem.compound:753
NADH + H+ Metabolite pubchem.compound:439153
Phosphocholine(Choline-P) Metabolite pubchem.compound:1014
1,2-diacyl-sn-glycero-3-phosphocholine(PC, Lecithin) Metabolite lipidmaps:LMGP01010000
1-acyl-sn-glycero-3-phosphate(Lysophosphatidic acid; LPA) Metabolite lipidmaps:LMGP10050000
Adenosine diphosphate(ADP) Metabolite pubchem.compound:6022
CTP Metabolite pubchem.compound:6176
Acyl coenzyme A(Acyl-CoA) Metabolite chebi:17984
Coenzyme A(CoA-SH) Metabolite pubchem.compound:6816
Cytidine triphosphate(CTP) Metabolite pubchem.compound:6176
3 (S-adenosylhomocysteine) Metabolite pubchem.compound:439155
1-Alkyldihydroxyacetone phosphate(Octanoyl DHAP) Metabolite pubchem.compound:53481029
1-Acyl dihydroxyacetone phosphate(Acyl-DHAP) Metabolite hmdb:HMDB0011750
1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(PG) Metabolite lipidmaps:LMGP04010000
Cardiolipin(DPG, CL) Metabolite chebi:28494
Inositol Metabolite pubchem.compound:892
Phosphatidylinositol3,4,5-triphosphate[PIP3(3',4',5')] Metabolite lipidmaps:LMGP09010001
1,2-diacyl-sn-glycero-3-phospho-(1'-myo-inositol)(PI) Metabolite lipidmaps:LMGP06010000
Cytidine monophosphate(CMP) Metabolite pubchem.compound:6131
1,2-diacyl-sn-glycero-3-cytidine-5'-diphosphate(CDP-DAG, CMP-PA) Metabolite lipidmaps:LMGP13010000
1D-myo-Inositol-1-P Metabolite pubchem.compound:5288642
Phosphatidylinositol-4,5-bisphosphate[PIP2(4',5')] Metabolite chebi:18348
D-Glucose-6-P Metabolite hmdb:HMDB0003498
Phosphatidylinositol-4-phosphate(PIP) Metabolite chebi:58178
Glycerol-3-P Metabolite pubchem.compound:7048686
CDP-DAG Metabolite lipidmaps:LMGP13010000
1,2-diacyl-sn-glycero-3-phosphoserine(PS) Metabolite lipidmaps:LMGP03010000
Phosphorylethanolamine Metabolite pubchem.compound:1015
1,2-diacyl-sn-glycero-3-phosphoethanolamine(PE) Metabolite lipidmaps:LMGP02010000
3 (S-adenosyl-methionine) Metabolite pubchem.compound:34756
Serine Metabolite pubchem.compound:5951
GPAT1 Protein uniprot:Q9HCL2
IPMK Protein uniprot:Q8NFU5
Acylglycerone-phosphate reductaseEC 1.1.1.101 Protein uniprot:P40471 (1-alkyl-sn-glycerol-3-phosphate dehydrogenase)
Acyl-CoA:EC 2.3.1.- Protein eccode:2.3.1.- 1-alkyl-sn-glycero-3-phosphate 2-O-acyltransferase
1-alkyl-2-acyl-sn-glycero-3-phosphate phosphatase(Phosphatidate phosphatase)EC 3.1.3.4 Protein uniprot:Q92539
CDP-ethanolamine:(Ethanolaminephosphotransferase)EC 2.7.8.1 Protein uniprot:Q92539 1-alkyl-2-acyl-sn-glycerophosphoethanolamine transferase
(Plasmanylethanolamine desaturase)EC 1.14.99.19 Protein eccode:1.14.99.19 1-alkyl-2-acyl-sn-glycerophoethanolamine desaturase
CDP-choline:1-alkyl-2-acyl-sn-glycerophosphocholine transferase(Diacylglycerol cholinephosphotransferase)EC 2.7.8.2 Protein uniprot:Q9Y6K0
Nitrogen group transferasaEC 2.6.-.- Protein eccode:2.6.-.-
Cytochrome b Protein interpro:IPR005797
Alkylglycerophosphate 2-O-acetyltransferaseEC 2.3.1.105 Protein eccode:2.3.1.105
AlkylacetylglycerophosphataseEC 3.1.3.59 Protein eccode:3.1.3.59
Diacylglycerol cholinephosphotransferase(Cholinephosphotransferase 1)EC 2.7.8.2 Protein uniprot:P17898
N-MethyltransferaseEC 2.1.1.- Protein eccode:2.1.1.-
Phospholipase CEC 3.1.4.3 Protein eccode:3.1.4.3
Ethanolamine-phosphotransferaseEC 2.7.8.1 Protein uniprot:Q9Y6K0
Phospholipase A2EC 3.1.1.4 Protein uniprot:P14555
1-Alkylglycerophosphocholine O-acetyltransferaseEC 2.3.1.67 Protein uniprot:P14555
Alkylglycerol kinaseEC 2.7.1.93 Protein eccode:2.7.1.93
Glycerol-3-phosphate dehydrogenase (NAD+)EC 1.1.1.8 Protein uniprot:P21695
Glycerol kinaseEC 2.7.1.30 Protein uniprot:P32189
2-acylglycerol-3-phosphate O-acyltransferaseEC 2.3.1.52 Protein eccode:2.3.1.52
Glycerol-3-phosphate 1-O-acyltransferaseEC 2.3.1.15, mitochondrial Protein eccode:2.3.1.15
Phosphatidate phosphataseEC 3.1.3.4 Protein uniprot:Q14693
Phosphatidate cytidylyltransferaseEC 2.7.7.41 Protein uniprot:O95674
Choline kinaseEC 2.7.1.32 Protein uniprot:Q9Y259
Choline-phosphate cytidylyltransferaseEC 2.7.7.15 Protein uniprot:Q9Y259
Diacylglycerol cholinephosphotransferaseEC 2.7.8.2 Protein uniprot:Q8WUD6
Phosphatidylethanolamine N-methyltransferaseEC 2.1.1.17 Protein uniprot:Q9UBM1
Alkyldihydroxyacetonephosphate synthase(Alkyl-DHAP synthase)EC 2.5.1.26 Protein uniprot:O00116
Dihydroxyacetone phosphate acyltransferaseEC 2.3.1.42 Protein uniprot:O15228
CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferaseEC 2.7.8.5 Protein uniprot:Q32NB8
PhosphatidylglycerophosphataseEC 3.1.3.27 Protein uniprot:Q8WUK0
Cardiolipin synthaseEC 2.7.8.- Protein uniprot:Q9UJA2
CDP-diacylglyreol-inositol 3-phosphatidyltransferaseEC 2.7.8.11 Protein uniprot:O14735
1-phosphatidylinositol 4-kinaseEC 2.7.1.67 Protein uniprot:Q9BTU6
1-phosphatidylinositol 4-phosphate 5-kinaseEC 2.7.1.68 Protein uniprot:Q99755
Phosphatidylinositol-4,5-bisphosphate 3-kinaseEC 2.7.1.153 Protein eccode:2.7.1.153
Diacylglycerol O-acyltransferaseEC 2.3.1.20 Protein uniprot:Q86VF5
Ethanolamine kinaseEC 2.7.1.82 Protein uniprot:Q9Y259
Ethanolamine-phosphate cytidylyltransferaseEC 2.7.7.14 Protein uniprot:Q99447
EthanolaminephosphotransferaseEC 2.7.8.1 Protein uniprot:Q9Y6K0
L-serine-phosphatidylethanolamine phosphatidyltransferaseEC 2.7.8.29 Protein uniprot:P48651
GPAT2 Protein uniprot:Q6NUI2
GPAT3 Protein uniprot:Q53EU6
GPAT4 Protein uniprot:Q86UL3
Glycerol-3-phosphate 1-O-acyltransferaseEC 2.3.1.15 Protein eccode:2.3.1.15
PK3CG Protein uniprot:P48736
PK3CA Protein uniprot:P42336
PK3CB Protein uniprot:P42338
PK3CD Protein uniprot:O00329

References

  1. Phospholipid synthesis in isolated fat cells. Studies of microsomal diacylglycerol cholinephosphotransferase and diacylglycerol ethanolaminephosphotransferase activities. Coleman R, Bell RM. J Biol Chem. 1977 May 10;252(9):3050–6. PubMed Europe PMC Scholia
  2. The influence of exogenous and of membrane-bound phosphatidate concentration on the activity of CTP: phosphatidate cytidylyltransferase and phosphatidate phosphohydrolase. van Heusden GP, van den Bosch H. Eur J Biochem. 1978 Mar 15;84(2):405–12. PubMed Europe PMC Scholia
  3. Metabolism of alkyldihydroxyacetone phosphate in rat brain. El-Bassiouni EA, Piantadosi C, Snyder F. Biochim Biophys Acta. 1975 Apr 18;388(1):5–11. PubMed Europe PMC Scholia
  4. Glycerophospholipid synthesis: improved general method and new analogs containing photoactivable groups. Gupta CM, Radhakrishnan R, Khorana HG. Proc Natl Acad Sci U S A. 1977 Oct;74(10):4315–9. PubMed Europe PMC Scholia
  5. The biosynthesis of cytidine diphosphate diacylglycerol in the mammalian cerebral cortex. Thompson RJ. Biochem Soc Trans. 1977;5(1):49–51. PubMed Europe PMC Scholia
  6. Biosynthesis of plasmalogens by the microsomal fraction of fischer R-3259 sarcoma. Influence of specific 2-acyl chains on the desaturation of 1-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine. Wykle RL, Schremmer JM. Biochemistry. 1979 Aug 7;18(16):3512–7. PubMed Europe PMC Scholia
  7. Plasmenylethanolamine: growth factor for cholesterol-reducing Eubacterium. Mott GE, Brinkley AW. J Bacteriol. 1979 Sep;139(3):755–60. PubMed Europe PMC Scholia
  8. Isolation of soluble proteins capable of stimulating aerobic plasmalogen biosynthesis. Paltauf F. Eur J Biochem. 1978 Apr;85(1):263–70. PubMed Europe PMC Scholia
  9. Triglycerides in clinical medicine. A review. Tzagournis M. Am J Clin Nutr. 1978 Aug;31(8):1437–52. PubMed Europe PMC Scholia
  10. Diacylglycerol acyltransferase from rat liver microsomes. Separation and acyl-donor specificity. Hosaka K, Schiele U, Numa S. Eur J Biochem. 1977 Jun 1;76(1):113–8. PubMed Europe PMC Scholia
  11. Metabolism of glycerol monoethers in cultured liver cells and implications for monoglyceride pathways. Mackenzie CG, Reiss OK, Moritz E, Mackenzie JB. J Lipid Res. 1976 Nov;17(6):629–36. PubMed Europe PMC Scholia
  12. Enzymic synthesis of 1-alkyl-2-acyl-sn-glycero-3-phosphorylethanolamine through ethanolaminephosphotransferase activity in the neuronal and glial cells of rabbit in vitro. Roberti R, Binaglia L, Francescangeli E, Goracci G, Porcellati G. Lipids. 1975 Mar;10(3):121–7. PubMed Europe PMC Scholia
  13. CDP-choline: 1,2-diacylglycerol cholinephosphotransferase from rat liver microsomes. II. Photoaffinity labeling by radioactive CDP-choline analogs. Ishidate K, Matsuo R, Nakazawa Y. Biochim Biophys Acta. 1992 Feb 20;1124(1):36–44. PubMed Europe PMC Scholia
  14. Alkylglycerol phosphotransferase. Snyder F. Methods Enzymol. 1992;209:211–5. PubMed Europe PMC Scholia
  15. 1-alkyl-2-acetyl-sn-glycero-3-phosphate phosphatase. Snyder F, Lee TC. Methods Enzymol. 1992;209:230–4. PubMed Europe PMC Scholia
  16. CDPdiacylglycerol synthase from yeast. Carman GM, Kelley MJ. Methods Enzymol. 1992;209:242–7. PubMed Europe PMC Scholia
  17. Ethanolamine-phosphate cytidylyltransferase. Tijburg LB, Vermeulen PS, van Golde LM. Methods Enzymol. 1992;209:258–63. PubMed Europe PMC Scholia
  18. Cholinephosphotransferase from mammalian sources. Cornell RB. Methods Enzymol. 1992;209:267–72. PubMed Europe PMC Scholia
  19. Glycerophospholipid metabolism: back to the future. Holmsen H, Hindenes JO, Fukami M. Thromb Res. 1992 Aug 1;67(3):313–23. PubMed Europe PMC Scholia
  20. Glycerophospholipid metabolism: back to the future. Holmsen H, Hindenes JO, Fukami M. Thromb Res. 1992 Aug 1;67(3):313–23. PubMed Europe PMC Scholia
  21. Reversibility of the reactions catalyzed by cholinephosphotransferase and ethanolaminephosphotransferase solubilized from rat-brain microsomes. Roberti R, Mancini A, Freysz L, Binaglia L. Biochim Biophys Acta. 1992 Dec 2;1165(2):183–8. PubMed Europe PMC Scholia
  22. Occurrence and functions of the phosphatidylinositol cycle in the myocardium. Lamers JM, Dekkers DH, Bezstarosti K, Meij JT, van Heugten HA. Mol Cell Biochem. 1992 Oct 21;116(1–2):59–67. PubMed Europe PMC Scholia
  23. Alkyldihydroxyacetonephosphate synthase. Brown A, Snyder F. Methods Enzymol. 1992;209:377–84. PubMed Europe PMC Scholia
  24. Acyl/alkyldihydroxyacetone phosphate reductase from guinea pig liver peroxisomes. Hajra AK, Datta SC, Ghosh MK. Methods Enzymol. 1992;209:402–7. PubMed Europe PMC Scholia
  25. Dihydroxyacetone phosphate acyltransferase. Webber KO, Hajra AK. Methods Enzymol. 1992;209:92–8. PubMed Europe PMC Scholia
  26. Diacylglycerol acyltransferase and monoacylglycerol acyltransferase from liver and intestine. Coleman RA. Methods Enzymol. 1992;209:98–104. PubMed Europe PMC Scholia
  27. Relative amounts of 1-O-alkyl- and 1-acyl-2-acetyl-sn-glycero-3-phosphocholine in stimulated endothelial cells. Whatley RE, Clay KL, Chilton FH, Triggiani M, Zimmerman GA, McIntyre TM, et al. Prostaglandins. 1992 Jan;43(1):21–9. PubMed Europe PMC Scholia
  28. Cardiolipins and biomembrane function. Hoch FL. Biochim Biophys Acta. 1992 Mar 26;1113(1):71–133. PubMed Europe PMC Scholia
  29. An update on PAF. Spencer DA. Clin Exp Allergy. 1992 May;22(5):521–4. PubMed Europe PMC Scholia
  30. PAF. A review of its effects, antagonists and possible future clinical implications (Part II). Koltai M, Hosford D, Guinot P, Esanu A, Braquet P. Drugs. 1991 Aug;42(2):174–204. PubMed Europe PMC Scholia
  31. Platelet activating factor (PAF). A review of its effects, antagonists and possible future clinical implications (Part I). Koltai M, Hosford D, Guinot P, Esanu A, Braquet P. Drugs. 1991 Jul;42(1):9–29. PubMed Europe PMC Scholia
  32. Platelet-activating factor (PAF): an introduction. Nojima S. Lipids. 1991 Dec;26(12):965–6. PubMed Europe PMC Scholia
  33. Biosynthesis of choline plasmalogens in neonatal rat myocytes. Lee TC, Qian CG, Snyder F. Arch Biochem Biophys. 1991 May 1;286(2):498–503. PubMed Europe PMC Scholia
  34. 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine: acetylhydrolase is associated primarily with low density lipoproteins in human blood. Muzia TI, Kulikov VN. Biokhimiia. 1991 Jun;56(6):1140–4. PubMed Europe PMC Scholia
  35. Synthesis of phosphatidylethanolamine and ethanolamine plasmalogen by the CDP-ethanolamine and decarboxylase pathways in rat heart, kidney and liver. Arthur G, Page L. Biochem J. 1991 Jan 1;273(Pt 1)(Pt 1):121–5. PubMed Europe PMC Scholia
  36. Structural and enzymological properties of cellular phospholipases A2. van den Bosch H, Aarsman AJ, van Schaik RH, Schalkwijk CG, Neijs FW, Sturk A. Biochem Soc Trans. 1990 Oct;18(5):781–5. PubMed Europe PMC Scholia
  37. Comparative anatomy of phospholipase A2 structures. Ward KB, Pattabiraman N. Adv Exp Med Biol. 1990;279:23–36. PubMed Europe PMC Scholia
  38. Molecular structure, developmental regulation, and evolution of the gene encoding glycerol-3-phosphate dehydrogenase isozymes in Drosophila melanogaster. Bewley GC, Cook JL. Prog Clin Biol Res. 1990;344:341–74. PubMed Europe PMC Scholia
  39. Structure, biosynthesis, and function of glycosylphosphatidylinositols. Thomas JR, Dwek RA, Rademacher TW. Biochemistry. 1990 Jun 12;29(23):5413–22. PubMed Europe PMC Scholia
  40. The sn-1,2-diacylglycerol cholinephosphotransferase of Saccharomyces cerevisiae. Nucleotide sequence, transcriptional mapping, and gene product analysis of the CPT1 gene. Hjelmstad RH, Bell RM. J Biol Chem. 1990 Jan 25;265(3):1755–64. PubMed Europe PMC Scholia
  41. Regulation of the synthesis of platelet-activating factor and its inactive storage precursor (1-alkyl-2-acyl-sn-glycero-3-phosphocholine) from 1-alkyl-2-acetyl-sn-glycerol by rabbit platelets. Lee TC, Malone B, Blank ML, Fitzgerald V, Snyder F. J Biol Chem. 1990 Jun 5;265(16):9181–7. PubMed Europe PMC Scholia
  42. Inositol lipids and phosphates. Downes CP, Carter AN. Curr Opin Cell Biol. 1990 Apr;2(2):185–91. PubMed Europe PMC Scholia
  43. Plasmenylcholine and phosphatidylcholine membrane bilayers possess distinct conformational motifs. Han XL, Gross RW. Biochemistry. 1990 May 22;29(20):4992–6. PubMed Europe PMC Scholia
  44. Plasmenylethanolamine is the major storage depot for arachidonic acid in rabbit vascular smooth muscle and is rapidly hydrolyzed after angiotensin II stimulation. Ford DA, Gross RW. Proc Natl Acad Sci U S A. 1989 May;86(10):3479–83. PubMed Europe PMC Scholia
  45. Biosynthesis of phosphatidylethanolamine via the CDP-ethanolamine route is an important pathway in isolated rat hepatocytes. Tijburg LB, Geelen MJ, Van Golde LM. Biochem Biophys Res Commun. 1989 May 15;160(3):1275–80. PubMed Europe PMC Scholia
  46. The relationship between phospholipases A2 and C in signal transduction. Lapetina EG, Crouch MF. Ann N Y Acad Sci. 1989;559:153–7. PubMed Europe PMC Scholia
  47. The de novo biosynthesis of platelet-activating factor in rat brain. Francescangeli E, Goracci G. Biochem Biophys Res Commun. 1989 May 30;161(1):107–12. PubMed Europe PMC Scholia
  48. An improved procedure for the purification of ethanolaminephosphotransferase. Reconstitution of the purified enzyme with lipids. Roberti R, Vecchini A, Freysz L, Masoom M, Binaglia L. Biochim Biophys Acta. 1989 Jul 17;1004(1):80–8. PubMed Europe PMC Scholia
  49. Regulation of the biosynthesis of triacylglycerol, phosphatidylcholine and phosphatidylethanolamine in the liver. Tijburg LB, Geelen MJ, van Golde LM. Biochim Biophys Acta. 1989 Jul 17;1004(1):1–19. PubMed Europe PMC Scholia
  50. The metabolism of glycerophospholipid and its regulation in monocytes and macrophages. Nakagawa Y, Waku K. Prog Lipid Res. 1989;28(3):205–43. PubMed Europe PMC Scholia
  51. Modulation of acetyl-CoA:1-alkyl-2-lyso-sn-glycero-3-phosphocholine (lyso-PAF) acetyltransferase in human polymorphonuclears. The role of cyclic AMP-dependent and phospholipid sensitive, calcium-dependent protein kinases. Nieto ML, Velasco S, Sanchez Crespo M. J Biol Chem. 1988 Apr 5;263(10):4607–11. PubMed Europe PMC Scholia
  52. Stimulation of the de novo pathway for the biosynthesis of platelet-activating factor (PAF) via cytidylyltransferase activation in cells with minimal endogenous PAF production. Blank ML, Lee YJ, Cress EA, Snyder F. J Biol Chem. 1988 Apr 25;263(12):5656–61. PubMed Europe PMC Scholia
  53. Ethanolaminephosphotransferase in rat lung: selectivity for endogenous and exogenous diacylglycerol. Ide H, Miller JC, Weinhold PA. Biochim Biophys Acta. 1988 May 2;960(1):119–24. PubMed Europe PMC Scholia
  54. Metabolism of 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine: a precursor of platelet-activating factor in macrophages. Waku K, Sugiura T, Nakagawa Y. Adv Prostaglandin Thromboxane Leukot Res. 1985;15:697–9. PubMed Europe PMC Scholia
  55. Phosphatidylinositol turnover in receptor mechanism and signal transduction. Hirasawa K, Nishizuka Y. Annu Rev Pharmacol Toxicol. 1985;25:147–70. PubMed Europe PMC Scholia
  56. Measurement of key enzyme activities involved in the metabolism of platelet activating factor. Snyder F, Blank M, Lee TC, Robinson M, Woodard D. Methods Enzymol. 1987;141:379–96. PubMed Europe PMC Scholia
  57. Metabolism of platelet activating factor and related ether lipids: enzymatic pathways, subcellular sites, regulation, and membrane processing. Snyder F. Prog Clin Biol Res. 1988;282:57–72. PubMed Europe PMC Scholia
  58. Phospholipase A2: function and pharmacological regulation. Chang J, Musser JH, McGregor H. Biochem Pharmacol. 1987 Aug 1;36(15):2429–36. PubMed Europe PMC Scholia
  59. Histochemical demonstration of cytosolic alpha-glycerophosphate dehydrogenase (EC 1.1.1.8) and mitochondrial alpha-glycerophosphate dehydrogenase (EC 1.1.99.5). Lake BD. J Neurol Sci. 1987 Dec;82(1–3):305–6. PubMed Europe PMC Scholia
  60. Distribution of alkylglycerone-phosphate synthase in subcellular fractions of rat liver. Rabert U, Völkl A, Debuch H. Biol Chem Hoppe Seyler. 1986 Mar;367(3):215–22. PubMed Europe PMC Scholia
  61. Metabolism of platelet activating factor (1-alkyl-2-acetyl-sn-glycero-3-phosphocholine) and 1-alkyl-2-acetyl-sn-glycerol by human endothelial cells. Blank ML, Spector AA, Kaduce TL, Lee TC, Snyder F. Biochim Biophys Acta. 1986 May 21;876(3):373–8. PubMed Europe PMC Scholia
  62. The catabolism of plasmenylcholine in the guinea pig heart. Arthur G, Page L, Mock T, Choy PC. Biochem J. 1986 Jun 1;236(2):475–80. PubMed Europe PMC Scholia
  63. Peroxisomal dihydroxyacetone phosphate acyltransferase. Effect of acetaldehyde on the intact and solubilized activity. Dobrowsky RT, Ballas LM. J Biol Chem. 1987 Mar 5;262(7):3136–9. PubMed Europe PMC Scholia
  64. Diacylglycerol synthesized in vitro from sn-glycerol 3-phosphate and the endogenous diacylglycerol are different substrate pools for the biosynthesis of phosphatidylcholine in rat lung microsomes. Rüstow B, Kunze D. Biochim Biophys Acta. 1985 Jul 9;835(2):273–8. PubMed Europe PMC Scholia
  65. Alkyldihydroxyacetonephosphate synthase mechanism: 18O studies of fatty acid release from acyldihydroxyacetone phosphate. Brown AJ, Glish GL, McBay EH, Snyder F. Biochemistry. 1985 Dec 31;24(27):8012–6. PubMed Europe PMC Scholia
  66. Biosynthesis of 1-alkyl-sn-glycero-3-phosphate via adenosine triphosphate:1-alkyl-sn-glycerol phosphotransferase. Rock CO, Snyder F. J Biol Chem. 1974 Sep 10;249(17):5382–7. PubMed Europe PMC Scholia
  67. The acyl dihydroxyacetone phosphate pathway for glycerolipid biosynthesis in mouse liver and Ehrlich ascites tumor cells. Agranoff BW, Hajra AK. Proc Natl Acad Sci U S A. 1971 Feb;68(2):411–5. PubMed Europe PMC Scholia
  68. Phosphatidylglycerols and lipoamino acids. Macfarlane MG. Adv Lipid Res. 1964;2:91–125. PubMed Europe PMC Scholia
  69. Synthesis and characterization of 1-O-alkyldihydroxyacetone phosphates and derivatives. Piantadosi C, Ishaq KS, Wykle RL, Snyder F. Biochemistry. 1971 Apr 13;10(8):1417–21. PubMed Europe PMC Scholia
  70. Studies on the CDP-ethanolamine-1,2-diglyceride ethanolaminephosphotransferase of rat brain. Ansell GB, Metcalfe RF. J Neurochem. 1971 Apr;18(4):647–65. PubMed Europe PMC Scholia
  71. Molecular cloning of the gene encoding CDPdiacylglycerol-inositol 3-phosphatidyl transferase in Saccharomyces cerevisiae. Nikawa J, Yamashita S. Eur J Biochem. 1984 Sep 3;143(2):251–6. PubMed Europe PMC Scholia
  72. Changes in CTP:phosphatidate cytidylyltransferase activity during rabbit lung development. Longmuir KJ, Johnston JM. Biochim Biophys Acta. 1980 Dec 5;620(3):500–8. PubMed Europe PMC Scholia
  73. Lung surfactant. Rooney SA. Environ Health Perspect. 1984 Apr;55:205–26. PubMed Europe PMC Scholia
  74. Partial purification and properties of mammalian phosphatidylglycerophosphatase. MacDonald PM, McMurray WC. Biochim Biophys Acta. 1980 Oct 6;620(1):80–9. PubMed Europe PMC Scholia
  75. The stimulation of rat liver microsomal CTP: phosphatidate cytidylyltransferase activity by guanosine triphosphate. Liteplo RG, Sribney M. Biochim Biophys Acta. 1980 Sep 8;619(3):660–8. PubMed Europe PMC Scholia
  76. Regulation of triacylglycerol synthesis in the liver: a decrease in diacylglycerol acyltransferase activity after treatment of isolated rat hepatocytes with glucagon. Haagsman HP, de Haas CG, Geelen MJ, van Golde LM. Biochim Biophys Acta. 1981 Apr 23;664(1):74–81. PubMed Europe PMC Scholia
  77. Optimal assay and subcellular location of phosphatidylglycerol synthesis in lung. Mavis RD, Vang MJ. Biochim Biophys Acta. 1981 May 22;664(2):409–15. PubMed Europe PMC Scholia
  78. Glycerolipid acyltransferases from rat liver: 1-acylglycerophosphate acyltransferase, 1-acylglycerophosphorylcholine acyltransferase, and diacylglycerol acyltransferase. Yamashita S, Hosaka K, Miki Y, Numa S. Methods Enzymol. 1981;71 Pt C:528–36. PubMed Europe PMC Scholia
  79. Yeast mutant defective in synthesis of phosphatidylinositol. Isolation and characterization of a CDPdiacylglycerol--inositol 3-phosphatidyltransferase Km mutant. Nikawa J, Yamashita S. Eur J Biochem. 1982 Jul;125(2):445–51. PubMed Europe PMC Scholia
  80. Phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate: lipids in search of a function. Downes P, Michell RH. Cell Calcium. 1982 Oct;3(4–5):467–502. PubMed Europe PMC Scholia
  81. The isozymes of membrane-associated enzymes: acetylcholinesterase, succinate dehydrogenase, and glycerol-3-phosphate dehydrogenase. Edwards YH, Shaw MA. Isozymes Curr Top Biol Med Res. 1983;10:125–46. PubMed Europe PMC Scholia
  82. Estimation of acyldihydroxyacetone phosphate and lysophosphatidate in animal tissues. Das AK, Hajra AK. Biochim Biophys Acta. 1984 Nov 14;796(2):178–89. PubMed Europe PMC Scholia
  83. Inhibition of the glycerol 3-phosphate oxidation by free fatty acids. Rauchová H, Drahota Z. Int J Biochem. 1984;16(2):243–5. PubMed Europe PMC Scholia
  84. Studies on ether phospholipids. II. Comparative composition of various tissues from human, rat and guinea pig. Diagne A, Fauvel J, Record M, Chap H, Douste-Blazy L. Biochim Biophys Acta. 1984 Apr 18;793(2):221–31. PubMed Europe PMC Scholia
  85. Structure and function of phospholipase A2. Verheij HM, Slotboom AJ, de Haas GH. Rev Physiol Biochem Pharmacol. 1981;91:91–203. PubMed Europe PMC Scholia
  86. Regulation of triacylglycerol synthesis in the liver. Modulation of diacylglycerol acyltransferase activity in vitro. Haagsman HP, de Haas CG, Geelen MJ, van Golde LM. J Biol Chem. 1982 Sep 25;257(18):10593–8. PubMed Europe PMC Scholia
  87. Glycerol-3-phosphate content and triacylglycerol synthesis in isolated hepatocytes from fed and starved rats. Debeer LJ, Declercq PE, Mannaerts GP. FEBS Lett. 1981 Feb 9;124(1):31–4. PubMed Europe PMC Scholia
  88. Glycerophospholipid metabolism in neuronal and glial cell-enriched fractions. Arienti G, Goracci G, Porcellati G. Neurochem Res. 1981 Jul;6(7):729–42. PubMed Europe PMC Scholia
  89. Solubilization, partial purification and characterization of rat liver microsomal diacylglycerol acyltransferase. Polokoff MA, Bell RM. Biochim Biophys Acta. 1980 Apr 18;618(1):129–42. PubMed Europe PMC Scholia
  90. Glycerol 3-phosphate-induced ATP production in intact mitochondria from pancreatic B-cells. Idahl LA, Lembert N. Biochem J. 1995 Nov 15;312 ( Pt 1)(Pt 1):287–92. PubMed Europe PMC Scholia
  91. Phospholipase A2 and G proteins. Axelrod J. Trends Neurosci. 1995 Feb;18(2):64–5. PubMed Europe PMC Scholia
  92. Eukaryotic phospholipid biosynthesis. Kent C. Annu Rev Biochem. 1995;64:315–43. PubMed Europe PMC Scholia
  93. Metabolic processing of PAF. Snyder F. Clin Rev Allergy. 1994;12(4):309–27. PubMed Europe PMC Scholia
  94. Lysophosphatidic acid, a multifunctional phospholipid messenger. Moolenaar WH. J Biol Chem. 1995 Jun 2;270(22):12949–52. PubMed Europe PMC Scholia
  95. Plasmenylethanolamine in human intestinal mucosa detected by an improved method for analysis of phospholipid. Nakanishi K, Yasugi E, Morita H, Dohi T, Oshima M. Biochem Mol Biol Int. 1994 Jun;33(3):457–62. PubMed Europe PMC Scholia
  96. Functional redundancy of CDP-ethanolamine and CDP-choline pathway enzymes in phospholipid biosynthesis: ethanolamine-dependent effects on steady-state membrane phospholipid composition in Saccharomyces cerevisiae. McGee TP, Skinner HB, Bankaitis VA. J Bacteriol. 1994 Nov;176(22):6861–8. PubMed Europe PMC Scholia
  97. Plasmenylcholine (1-O-alk-1’-enyl-2-acyl-sn-glycero-3-phosphocholine) biosynthesis in guinea-pig heart and liver: cholinephosphotransferase is a bifunctional enzyme for the synthesis of phosphatidylcholine and plasmenylcholine. Xu YF, O K, Choy PC. Biochem J. 1994 Jul 1;301 ( Pt 1)(Pt 1):131–7. PubMed Europe PMC Scholia
  98. Chimeric enzymes. Structure-function analysis of segments of sn-1,2-diacylglycerol choline- and ethanolaminephosphotransferases. Hjelmstad RH, Morash SC, McMaster CR, Bell RM. J Biol Chem. 1994 Aug 19;269(33):20995–1002. PubMed Europe PMC Scholia
  99. Phases and phase transitions of the hydrated phosphatidylethanolamines. Koynova R, Caffrey M. Chem Phys Lipids. 1994 Jan;69(1):1–34. PubMed Europe PMC Scholia
  100. sn-1,2-diacylglycerol cholinephosphotransferase from pig liver: mixed micellar assay and kinetic analysis of the partially pure enzyme. Bru R, Blöchliger E, Luisi PL. Arch Biochem Biophys. 1993 Dec;307(2):295–303. PubMed Europe PMC Scholia
  101. Organization of the phosphoinositide cycle. Assessment of inositol transferase activity in purified plasma membranes. Santiago OM, Rosenberg LI, Monaco ME. Biochem J. 1993 Feb 15;290 ( Pt 1)(Pt 1):179–83. PubMed Europe PMC Scholia
  102. CDPcholine:1,2-diacylglycerol cholinephosphotransferase from rat liver microsomes. I. Solubilization and characterization of the partially purified enzyme and the possible existence of an endogenous inhibitor. Ishidate K, Matsuo R, Nakazawa Y. Lipids. 1993 Feb;28(2):89–96. PubMed Europe PMC Scholia
  103. Evidence for biosynthesis of plasmenylcholine from plasmenylethanolamine in HL-60 cells. Blank ML, Fitzgerald V, Lee TC, Snyder F. Biochim Biophys Acta. 1993 Feb 24;1166(2–3):309–12. PubMed Europe PMC Scholia
  104. Factors affecting the stability of detergent-solubilized cholinephosphotransferase and ethanolaminephosphotransferase. Mancini A, Roberti R, Binaglia L, el Missiri A, Freysz L. Membr Biochem. 1993;10(1):43–52. PubMed Europe PMC Scholia
  105. Platelet-activating factor: receptors and signal transduction. Chao W, Olson MS. Biochem J. 1993 Jun 15;292 ( Pt 3)(Pt 3):617–29. PubMed Europe PMC Scholia
  106. Outer-membrane porins from gram-negative bacteria stimulate platelet-activating-factor biosynthesis by cultured human endothelial cells. Tufano MA, Biancone L, Rossano F, Capasso C, Baroni A, De Martino A, et al. Eur J Biochem. 1993 Jun 15;214(3):685–93. PubMed Europe PMC Scholia
  107. Phosphatidylethanolamine: ceramide-ethanolaminephosphotransferase activity in synaptic plasma membrane vesicles. Influence of some cations and phospholipid environment on transferase activity. Further proof of its location. Maurice A, Malgat M. Int J Biochem. 1993 Aug;25(8):1183–7. PubMed Europe PMC Scholia
  108. Biosynthesis of platelet-activating factor (PAF) induced by chemotactic peptide is modulated at the lyso-PAF:acetyl-CoA acetyltransferase level by calcium transient and phosphatidic acid. Garcia C, Montero M, Alvarez J, Sanchez Crespo M. J Biol Chem. 1993 Feb 25;268(6):4001–8. PubMed Europe PMC Scholia
  109. Exclusive localization in peroxisomes of dihydroxyacetone phosphate acyltransferase and alkyl-dihydroxyacetone phosphate synthase in rat liver. Singh H, Beckman K, Poulos A. J Lipid Res. 1993 Mar;34(3):467–77. PubMed Europe PMC Scholia
  110. Phospholipase A2 enzymes: regulation and inhibition. Glaser KB, Mobilio D, Chang JY, Senko N. Trends Pharmacol Sci. 1993 Mar;14(3):92–8. PubMed Europe PMC Scholia
  111. Mass spectrometric identification and quantitation of arachidonate-containing phospholipids in pancreatic islets: prominence of plasmenylethanolamine molecular species. Ramanadham S, Bohrer A, Mueller M, Jett P, Gross RW, Turk J. Biochemistry. 1993 May 25;32(20):5339–51. PubMed Europe PMC Scholia
  112. Metabolism of glycerol 3-phosphate by mature boar spermatozoa. Jones AR, Gillan L. J Reprod Fertil. 1996 Mar;106(2):321–7. PubMed Europe PMC Scholia
  113. CDP-choline: pharmacological and clinical review. Secades JJ, Frontera G. Methods Find Exp Clin Pharmacol. 1995 Oct;17 Suppl B:1–54. PubMed Europe PMC Scholia
  114. Alkylglycerophosphate acetyltransferase and lyso platelet activating factor acetyltransferase, two key enzymes in the synthesis of platelet activating factor, are found in neuronal nuclei isolated from cerebral cortex. Baker RR, Chang HY. Biochim Biophys Acta. 1996 Aug 16;1302(3):257–63. PubMed Europe PMC Scholia
  115. Cytosolic phospholipase A2. Clark JD, Schievella AR, Nalefski EA, Lin LL. J Lipid Mediat Cell Signal. 1995 Oct;12(2–3):83–117. PubMed Europe PMC Scholia
  116. Enzymes of platelet activating factor synthesis in brain. Baker RR. Neurochem Res. 1995 Nov;20(11):1345–51. PubMed Europe PMC Scholia
  117. Plasmalogens, phospholipases A2 and signal transduction. Farooqui AA, Yang HC, Horrocks LA. Brain Res Brain Res Rev. 1995 Sep;21(2):152–61. PubMed Europe PMC Scholia
  118. Phosphatidate phosphatases of mammals, yeast, and higher plants. Kocsis MG, Weselake RJ. Lipids. 1996 Aug;31(8):785–802. PubMed Europe PMC Scholia
  119. Activities of enzymes in platelet activating factor biosynthetic pathways in the gerbil model of cerebral ischemia. Siegel A, Baker RR. Biochem Cell Biol. 1996;74(3):347–54. PubMed Europe PMC Scholia
  120. Lipid biosynthesis in peroxisomes. Hajra AK, Das AK. Ann N Y Acad Sci. 1996 Dec 27;804:129–41. PubMed Europe PMC Scholia
  121. Cloning of a human cDNA for CTP-phosphoethanolamine cytidylyltransferase by complementation in vivo of a yeast mutant. Nakashima A, Hosaka K, Nikawa J. J Biol Chem. 1997 Apr 4;272(14):9567–72. PubMed Europe PMC Scholia
  122. Biosynthesis of platelet-activating factor and enzyme inhibitors. Snyder F, Fitzgerald V, Blank ML. Adv Exp Med Biol. 1996;416:5–10. PubMed Europe PMC Scholia
  123. Platelet-activating factor (PAF): signalling and adhesion in cell-cell interactions. Zimmerman GA, Elstad MR, Lorant DE, Mclntyre TM, Prescott SM, Topham MK, et al. Adv Exp Med Biol. 1996;416:297–304. PubMed Europe PMC Scholia
  124. Biosynthesis of plasmenylethanolamine (1-O-alk-1’-enyl-2-acyl-sn-glycero-3-phosphoethanolamine) in the guinea pig heart. Xu FY, O K, Choy PC. J Lipid Res. 1997 Apr;38(4):670–9. PubMed Europe PMC Scholia
  125. cDNA cloning and expression of murine 1-acyl-sn-glycerol-3-phosphate acyltransferase. Kume K, Shimizu T. Biochem Biophys Res Commun. 1997 Aug 28;237(3):663–6. PubMed Europe PMC Scholia
  126. Mammalian mitochondrial glycerol-3-phosphate acyltransferase. Dircks LK, Sul HS. Biochim Biophys Acta. 1997 Sep 4;1348(1–2):17–26. PubMed Europe PMC Scholia
  127. Dihydroxyacetone phosphate acyltransferase. Hajra AK. Biochim Biophys Acta. 1997 Sep 4;1348(1–2):27–34. PubMed Europe PMC Scholia
  128. Alkyl-dihydroxyacetonephosphate synthase. van den Bosch H, de Vet EC. Biochim Biophys Acta. 1997 Sep 4;1348(1–2):35–44. PubMed Europe PMC Scholia
  129. Phosphatidate phosphatases and diacylglycerol pyrophosphate phosphatases in Saccharomyces cerevisiae and Escherichia coli. Carman GM. Biochim Biophys Acta. 1997 Sep 4;1348(1–2):45–55. PubMed Europe PMC Scholia
  130. Choline kinase from yeast. Yamashita S, Hosaka K. Biochim Biophys Acta. 1997 Sep 4;1348(1–2):63–9. PubMed Europe PMC Scholia
  131. Choline/ethanolamine kinase from mammalian tissues. Ishidate K. Biochim Biophys Acta. 1997 Sep 4;1348(1–2):70–8. PubMed Europe PMC Scholia
  132. CTP:phosphocholine cytidylyltransferase. Kent C. Biochim Biophys Acta. 1997 Sep 4;1348(1–2):79–90. PubMed Europe PMC Scholia
  133. CDP-choline:1,2-diacylglycerol cholinephosphotransferase. McMaster CR, Bell RM. Biochim Biophys Acta. 1997 Sep 4;1348(1–2):100–10. PubMed Europe PMC Scholia
  134. CDP-choline:alkylacetylglycerol cholinephosphotransferase catalyzes the final step in the de novo synthesis of platelet-activating factor. Snyder F. Biochim Biophys Acta. 1997 Sep 4;1348(1–2):111–6. PubMed Europe PMC Scholia
  135. CDP-ethanolamine:1,2-diacylglycerol ethanolaminephosphotransferase. McMaster CR, Bell RM. Biochim Biophys Acta. 1997 Sep 4;1348(1–2):117–23. PubMed Europe PMC Scholia
  136. Phosphatidylethanolamine N-methyltransferase from liver. Vance DE, Walkey CJ, Cui Z. Biochim Biophys Acta. 1997 Sep 4;1348(1–2):142–50. PubMed Europe PMC Scholia
  137. CDP-diacylglycerol synthase from mammalian tissues. Heacock AM, Agranoff BW. Biochim Biophys Acta. 1997 Sep 4;1348(1–2):166–72. PubMed Europe PMC Scholia
  138. Phosphatidylinositol synthase from yeast. Nikawa J, Yamashita S. Biochim Biophys Acta. 1997 Sep 4;1348(1–2):173–8. PubMed Europe PMC Scholia
  139. Phosphatidylinositol synthase from mammalian tissues. Antonsson B. Biochim Biophys Acta. 1997 Sep 4;1348(1–2):179–86. PubMed Europe PMC Scholia
  140. Cardiolipin synthase from yeast. Schlame M, Greenberg ML. Biochim Biophys Acta. 1997 Sep 4;1348(1–2):201–6. PubMed Europe PMC Scholia
  141. Cardiolipin synthase from mammalian mitochondria. Schlame M, Hostetler KY. Biochim Biophys Acta. 1997 Sep 4;1348(1–2):207–13. PubMed Europe PMC Scholia
  142. Phosphatidylethanolamine N-methyltransferase: unexpected findings from curiosity-driven research. Vance DE. Eur J Med Res. 1996 Jan 19;1(4):182–8. PubMed Europe PMC Scholia
  143. Plasmalogens effectively reduce the surface tension of surfactant-like phospholipid mixtures. Rüdiger M, Kolleck I, Putz G, Wauer RR, Stevens P, Rüstow B. Am J Physiol. 1998 Jan;274(1):L143-8. PubMed Europe PMC Scholia
  144. Purification and characterization of phosphatidylglycerolphosphate synthase from Schizosaccharomyces pombe. Jiang F, Kelly BL, Hagopian K, Greenberg ML. J Biol Chem. 1998 Feb 20;273(8):4681–8. PubMed Europe PMC Scholia
  145. The bioregulatory role of platelet-activating factor in intracellular processes and cell-cell interactions. Kulikov VI, Muzya GI. Biochemistry (Mosc). 1998 Jan;63(1):47–54. PubMed Europe PMC Scholia
  146. DAG second messengers: molecular switches and growth control. Quest AF, Ghosh S, Xie WQ, Bell RM. Adv Exp Med Biol. 1997;400A:297–303. PubMed Europe PMC Scholia
  147. Alkyl-dihydroxyacetonephosphate synthase. Fate in peroxisome biogenesis disorders and identification of the point mutation underlying a single enzyme deficiency. de Vet EC, Ijlst L, Oostheim W, Wanders RJ, van den Bosch H. J Biol Chem. 1998 Apr 24;273(17):10296–301. PubMed Europe PMC Scholia
  148. Phosphoinositide 4- and 5-kinases and the cellular roles of phosphatidylinositol 4,5-bisphosphate. Hsuan JJ, Minogue S, dos Santos M. Adv Cancer Res. 1998;74:167–216. PubMed Europe PMC Scholia
  149. Chronic dietary n-3 polyunsaturated fatty acids deficiency affects the fatty acid composition of plasmenylethanolamine and phosphatidylethanolamine differently in rat frontal cortex, striatum, and cerebellum. Favrelière S, Barrier L, Durand G, Chalon S, Tallineau C. Lipids. 1998 Apr;33(4):401–7. PubMed Europe PMC Scholia
  150. Phosphatidylinositol 4-kinases. Gehrmann T, Heilmeyer LM Jr. Eur J Biochem. 1998 Apr 15;253(2):357–70. PubMed Europe PMC Scholia
  151. Why has phosphatidylethanolamine N-methyltransferase survived in evolution? Vance DE, Walkey CJ, Agellon LB. Biochem Soc Trans. 1998 Aug;26(3):337–40. PubMed Europe PMC Scholia
  152. Phosphatidylinositol 4-kinases. Balla T. Biochim Biophys Acta. 1998 Dec 8;1436(1–2):69–85. PubMed Europe PMC Scholia
  153. Cloning and expression of a human choline/ethanolaminephosphotransferase: synthesis of phosphatidylcholine and phosphatidylethanolamine. Henneberry AL, McMaster CR. Biochem J. 1999 Apr 15;339 ( Pt 2)(Pt 2):291–8. PubMed Europe PMC Scholia
  154. CTP:phosphocholine cytidylyltransferase: insights into regulatory mechanisms and novel functions. Clement JM, Kent C. Biochem Biophys Res Commun. 1999 Apr 21;257(3):643–50. PubMed Europe PMC Scholia
  155. Alkyl-dihydroxyacetone phosphate synthase and dihydroxyacetone phosphate acyltransferase form a protein complex in peroxisomes. Biermann J, Just WW, Wanders RJ, Van Den Bosch H. Eur J Biochem. 1999 Apr;261(2):492–9. PubMed Europe PMC Scholia
  156. Regulation of phosphatidylinositol 4,5-bisphosphate levels and its roles in cytoskeletal re-organization and malignant transformation. Takenawa T, Itoh T, Fukami K. Chem Phys Lipids. 1999 Apr;98(1–2):13–22. PubMed Europe PMC Scholia
  157. Identification and characterization of the mouse cDNA encoding acyl-CoA:dihydroxyacetone phosphate acyltransferase. Ofman R, Hogenhout EM, Wanders RJ. Biochim Biophys Acta. 1999 Jul 9;1439(1):89–94. PubMed Europe PMC Scholia
  158. Structure and functional properties of diacylglycerols in membranes. Goñi FM, Alonso A. Prog Lipid Res. 1999 Jan;38(1):1–48. PubMed Europe PMC Scholia
  159. Biosynthesis and function of phosphatidylglycerol and cardiolipin in animal cells. Kawasaki K, Nishijima M. Tanpakushitsu Kakusan Koso. 1999 Jun;44(8 Suppl):1167–72. PubMed Europe PMC Scholia
  160. Phosphatidylinositol 4-kinases. Assays and product analysis. Meyers RE, Cantley LC. Methods Mol Biol. 1998;105:99–108. PubMed Europe PMC Scholia
  161. Ether lipid biosynthesis: alkyl-dihydroxyacetonephosphate synthase protein deficiency leads to reduced dihydroxyacetonephosphate acyltransferase activities. de Vet EC, Ijlst L, Oostheim W, Dekker C, Moser HW, van Den Bosch H, et al. J Lipid Res. 1999 Nov;40(11):1998–2003. PubMed Europe PMC Scholia
  162. Mobilisation of triacylglycerol stores. Gibbons GF, Islam K, Pease RJ. Biochim Biophys Acta. 2000 Jan 3;1483(1):37–57. PubMed Europe PMC Scholia
  163. Alkyl-dihydroxyacetonephosphate synthase. Presence and role of flavin adenine dinucleotide. de Vet EC, Hilkes YH, Fraaije MW, van den Bosch H. J Biol Chem. 2000 Mar 3;275(9):6276–83. PubMed Europe PMC Scholia
  164. Platelet-activating factor (PAF) receptor and genetically engineered PAF receptor mutant mice. Ishii S, Shimizu T. Prog Lipid Res. 2000 Jan;39(1):41–82. PubMed Europe PMC Scholia
  165. Triglycerides and atherosclerosis: to feast or fast. Cabezas MC, Erkelens DW. Neth J Med. 2000 Mar;56(3):110–8. PubMed Europe PMC Scholia
  166. PIP2 and PIP3: complex roles at the cell surface. Czech MP. Cell. 2000 Mar 17;100(6):603–6. PubMed Europe PMC Scholia
  167. Triglyceride synthesis: insights from the cloning of diacylglycerol acyltransferase. Farese RV Jr, Cases S, Smith SJ. Curr Opin Lipidol. 2000 Jun;11(3):229–34. PubMed Europe PMC Scholia
  168. Cloning, genomic organization, and characterization of a human cholinephosphotransferase. Henneberry AL, Wistow G, McMaster CR. J Biol Chem. 2000 Sep 22;275(38):29808–15. PubMed Europe PMC Scholia
  169. Lipid acetylation reactions and the metabolism of platelet-activating factor. Baker RR. Neurochem Res. 2000 May;25(5):677–83. PubMed Europe PMC Scholia
  170. Overexpression of a mammalian ethanolamine-specific kinase accelerates the CDP-ethanolamine pathway. Lykidis A, Wang J, Karim MA, Jackowski S. J Biol Chem. 2001 Jan 19;276(3):2174–9. PubMed Europe PMC Scholia
  171. Purification of phosphatidylglycerophosphate synthase from Chinese hamster ovary cells. Kawasaki K, Kuge O, Yamakawa Y, Nishijima M. Biochem J. 2001 Feb 15;354(Pt 1):9–15. PubMed Europe PMC Scholia
  172. Plasmalogens: biosynthesis and functions. Nagan N, Zoeller RA. Prog Lipid Res. 2001 May;40(3):199–229. PubMed Europe PMC Scholia
  173. Genetic determinants of plasma triglycerides: impact of rare and common mutations. Talmud PJ. Curr Atheroscler Rep. 2001 May;3(3):191–9. PubMed Europe PMC Scholia
  174. Lysophosphatidic acid synthesis and release. Pagès C, Simon MF, Valet P, Saulnier-Blache JS. Prostaglandins Other Lipid Mediat. 2001 Apr;64(1–4):1–10. PubMed Europe PMC Scholia
  175. Alkyl-dihydroxyacetonephosphate synthase. de Vet EC, van den Bosch H. Cell Biochem Biophys. 2000;32 Spring:117–21. PubMed Europe PMC Scholia
  176. PIP3, PIP2, and cell movement--similar messages, different meanings? Insall RH, Weiner OD. Dev Cell. 2001 Dec;1(6):743–7. PubMed Europe PMC Scholia
  177. Platelet-activating factor receptor. Honda Z ichiro, Ishii S, Shimizu T. J Biochem. 2002 Jun;131(6):773–9. PubMed Europe PMC Scholia
  178. PC and PE synthesis: mixed micellar analysis of the cholinephosphotransferase and ethanolaminephosphotransferase activities of human choline/ethanolamine phosphotransferase 1 (CEPT1). Wright MM, McMaster CR. Lipids. 2002 Jul;37(7):663–72. PubMed Europe PMC Scholia
  179. Aging and acyl-CoA binding protein alter mitochondrial glycerol-3-phosphate acyltransferase activity. Kannan L, Knudsen J, Jolly CA. Biochim Biophys Acta. 2003 Feb 20;1631(1):12–6. PubMed Europe PMC Scholia
  180. Triacylglycerol biosynthesis in yeast. Sorger D, Daum G. Appl Microbiol Biotechnol. 2003 May;61(4):289–99. PubMed Europe PMC Scholia
  181. Mammalian phosphatidylinositol 4-kinases. Heilmeyer LMG Jr, Vereb G Jr, Vereb G, Kakuk A, Szivák I. IUBMB Life. 2003 Feb;55(2):59–65. PubMed Europe PMC Scholia
  182. Purification of phosphatidylglycerophosphate synthase from cultured mammalian cells. Kawasaki K, Nishijima M. Methods Mol Biol. 2003;228:175–86. PubMed Europe PMC Scholia
  183. Direct synthesis of plasmenylcholine from allyl-substituted glycerols. Shin J, Thompson DH. J Org Chem. 2003 Aug 22;68(17):6760–6. PubMed Europe PMC Scholia
  184. Molecular and cell biology of phosphatidylserine and phosphatidylethanolamine metabolism. Vance JE. Prog Nucleic Acid Res Mol Biol. 2003;75:69–111. PubMed Europe PMC Scholia
  185. Structural characterization of plasmenylcholine photooxidation products. Thompson DH, Inerowicz HD, Grove J, Sarna T. Photochem Photobiol. 2003 Oct;78(4):323–30. PubMed Europe PMC Scholia
  186. Control of the CDPethanolamine pathway in mammalian cells: effect of CTP:phosphoethanolamine cytidylyltransferase overexpression and the amount of intracellular diacylglycerol. Bleijerveld OB, Klein W, Vaandrager AB, Helms JB, Houweling M. Biochem J. 2004 May 1;379(Pt 3):711–9. PubMed Europe PMC Scholia
  187. Phosphatidylglycerol and sulfoquinovosyldiacylglycerol: anionic membrane lipids and phosphate regulation. Frentzen M. Curr Opin Plant Biol. 2004 Jun;7(3):270–6. PubMed Europe PMC Scholia
  188. Preparation of plasmenylcholine lipids and plasmenyl-type liposome dispersions. Thompson DH, Shin J, Boomer J, Kim JM. Methods Enzymol. 2004;387:153–68. PubMed Europe PMC Scholia
  189. The ins and outs of lysophosphatidic acid signaling. Moolenaar WH, van Meeteren LA, Giepmans BNG. Bioessays. 2004 Aug;26(8):870–81. PubMed Europe PMC Scholia
  190. Lysophosphatidic acid: a “bioactive” phospholipid. Saulnier-Blache JS. Med Sci (Paris). 2004;20(8–9):799–803. PubMed Europe PMC Scholia
  191. Phosphatidylinositol phosphate kinases. Giudici ML, Hinchliffe KA, Irvine RF. J Endocrinol Invest. 2004;27(6 Suppl):137–42. PubMed Europe PMC Scholia
  192. CTP: Phosphocholine cytidylyltransferase: paving the way from gene to membrane. Jackowski S, Fagone P. J Biol Chem. 2005 Jan 14;280(2):853–6. PubMed Europe PMC Scholia
  193. Role of mitochondria in toxic oxidative stress. Fariss MW, Chan CB, Patel M, Van Houten B, Orrenius S. Mol Interv. 2005 Apr;5(2):94–111. PubMed Europe PMC Scholia
  194. Mitochondrial glycerol-3-phosphate acyltransferase-1 is essential in liver for the metabolism of excess acyl-CoAs. Hammond LE, Neschen S, Romanelli AJ, Cline GW, Ilkayeva OR, Shulman GI, et al. J Biol Chem. 2005 Jul 8;280(27):25629–36. PubMed Europe PMC Scholia
  195. In situ hybridization of dihydroxyacetone phosphate acyltransferase, the regulating enzyme involved in plasmalogen biosynthesis. André A, Tessier C, Brétillon L, Sébédio JL, Chardigny JM. Brain Res Mol Brain Res. 2005 May 20;136(1–2):142–7. PubMed Europe PMC Scholia
  196. Regulation of ion channels by phosphatidylinositol 4,5-bisphosphate. Suh BC, Hille B. Curr Opin Neurobiol. 2005 Jun;15(3):370–8. PubMed Europe PMC Scholia
  197. Metabolism and functions of phosphatidylserine. Vance JE, Steenbergen R. Prog Lipid Res. 2005 Jul;44(4):207–34. PubMed Europe PMC Scholia
  198. Choline kinase: a novel target for antitumor drugs. Lacal JC. IDrugs. 2001 Apr;4(4):419–26. PubMed Europe PMC Scholia
  199. From transcription to mRNA: PAF provides a new path. Rosonina E, Manley JL. Mol Cell. 2005 Oct 28;20(2):167–8. PubMed Europe PMC Scholia
  200. Diacylglycerol: efficacy and mechanism of action of an anti-obesity agent. Rudkowska I, Roynette CE, Demonty I, Vanstone CA, Jew S, Jones PJH. Obes Res. 2005 Nov;13(11):1864–76. PubMed Europe PMC Scholia
  201. A regulatory role for 1-acylglycerol-3-phosphate-O-acyltransferase 2 in adipocyte differentiation. Gale SE, Frolov A, Han X, Bickel PE, Cao L, Bowcock A, et al. J Biol Chem. 2006 Apr 21;281(16):11082–9. PubMed Europe PMC Scholia
  202. Facile syntheses of acyl dihydroxyacetone phosphates and lysophosphatidic acids having different acyl groups. Das AK, Milam JE, Reddy RC, Hajra AK. J Lipid Res. 2006 Aug;47(8):1874–80. PubMed Europe PMC Scholia
  203. Choline kinase: an important target for cancer. Janardhan S, Srivani P, Sastry GN. Curr Med Chem. 2006;13(10):1169–86. PubMed Europe PMC Scholia
  204. Crystal structure of phosphatidylglycerophosphatase (PGPase), a putative membrane-bound lipid phosphatase, reveals a novel binuclear metal binding site and two “proton wires.” Kumaran D, Bonanno JB, Burley SK, Swaminathan S. Proteins. 2006 Sep 1;64(4):851–62. PubMed Europe PMC Scholia
  205. Selective plasmenylcholine oxidation by hypochlorous acid: formation of lysophosphatidylcholine chlorohydrins. Messner MC, Albert CJ, Hsu FF, Ford DA. Chem Phys Lipids. 2006 Oct;144(1):34–44. PubMed Europe PMC Scholia
  206. Role of cardiolipin alterations in mitochondrial dysfunction and disease. Chicco AJ, Sparagna GC. Am J Physiol Cell Physiol. 2007 Jan;292(1):C33-44. PubMed Europe PMC Scholia
  207. Crystallization and preliminary X-ray analysis of CTP:phosphoethanolamine cytidylyltransferase (ECT) from Saccharomyces cerevisiae. Ohtsuka J, Nagata K, Lee WC, Ono Y, Fukuda R, Ohta A, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Oct 1;62(Pt 10):1003–5. PubMed Europe PMC Scholia
  208. Phosphatidylethanolamine N-methyltransferase and regulation of homocysteine. Hartz CS, Schalinske KL. Nutr Rev. 2006 Oct;64(10 Pt 1):465–7. PubMed Europe PMC Scholia
  209. 1 -O-alkyl-2-(omega-oxo)acyl-sn-glycerols from shark oil and human milk fat are potential precursors of PAF mimics and GHB. Hartvigsen K, Ravandi A, Harkewicz R, Kamido H, Bukhave K, Hølmera G, et al. Lipids. 2006 Jul;41(7):679–93. PubMed Europe PMC Scholia
  210. Roles of phosphatidate phosphatase enzymes in lipid metabolism. Carman GM, Han GS. Trends Biochem Sci. 2006 Dec;31(12):694–9. PubMed Europe PMC Scholia
  211. Regulation of triglyceride metabolism. I. Eukaryotic neutral lipid synthesis: “Many ways to skin ACAT or a DGAT.” Turkish A, Sturley SL. Am J Physiol Gastrointest Liver Physiol. 2007 Apr;292(4):G953-7. PubMed Europe PMC Scholia
  212. Identification and characterization of human ethanolaminephosphotransferase1. Horibata Y, Hirabayashi Y. J Lipid Res. 2007 Mar;48(3):503–8. PubMed Europe PMC Scholia
  213. Diacylglycerol, when simplicity becomes complex. Carrasco S, Mérida I. Trends Biochem Sci. 2007 Jan;32(1):27–36. PubMed Europe PMC Scholia
  214. Citicoline: pharmacological and clinical review, 2006 update. Secades JJ, Lorenzo JL. Methods Find Exp Clin Pharmacol. 2006 Sep;28 Suppl B:1–56. PubMed Europe PMC Scholia
  215. A single enzyme catalyzes both platelet-activating factor production and membrane biogenesis of inflammatory cells. Cloning and characterization of acetyl-CoA:LYSO-PAF acetyltransferase. Shindou H, Hishikawa D, Nakanishi H, Harayama T, Ishii S, Taguchi R, et al. J Biol Chem. 2007 Mar 2;282(9):6532–9. PubMed Europe PMC Scholia
  216. Cardiolipin: setting the beat of apoptosis. Gonzalvez F, Gottlieb E. Apoptosis. 2007 May;12(5):877–85. PubMed Europe PMC Scholia
  217. Chemical and enzymatic routes to dihydroxyacetone phosphate. Schümperli M, Pellaux R, Panke S. Appl Microbiol Biotechnol. 2007 May;75(1):33–45. PubMed Europe PMC Scholia
  218. Target-specific PIP(2) signalling: how might it work? Gamper N, Shapiro MS. J Physiol. 2007 Aug 1;582(Pt 3):967–75. PubMed Europe PMC Scholia
  219. De novo biosynthesis of the late endosome lipid, bis(monoacylglycero)phosphate. Hullin-Matsuda F, Kawasaki K, Delton-Vandenbroucke I, Xu Y, Nishijima M, Lagarde M, et al. J Lipid Res. 2007 Sep;48(9):1997–2008. PubMed Europe PMC Scholia
  220. Alternative splicing of CTP:phosphoethanolamine cytidylyltransferase produces two isoforms that differ in catalytic properties. Tie A, Bakovic M. J Lipid Res. 2007 Oct;48(10):2172–81. PubMed Europe PMC Scholia
  221. The CDP-ethanolamine pathway and phosphatidylserine decarboxylation generate different phosphatidylethanolamine molecular species. Bleijerveld OB, Brouwers JFHM, Vaandrager AB, Helms JB, Houweling M. J Biol Chem. 2007 Sep 28;282(39):28362–72. PubMed Europe PMC Scholia
  222. Hepatic phosphatidylethanolamine N-methyltransferase, unexpected roles in animal biochemistry and physiology. Vance DE, Li Z, Jacobs RL. J Biol Chem. 2007 Nov 16;282(46):33237–41. PubMed Europe PMC Scholia
  223. PIP3 pathway in regulatory T cells and autoimmunity. Kashiwada M, Lu P, Rothman PB. Immunol Res. 2007;39(1–3):194–224. PubMed Europe PMC Scholia
  224. Complex roles of PIP2 in the regulation of ion channels and transporters. Huang CL. Am J Physiol Renal Physiol. 2007 Dec;293(6):F1761-5. PubMed Europe PMC Scholia
  225. P.S. to PS (phosphatidylserine)--pertinent proteins in apoptotic cell clearance. Schlegel RA, Williamson P. Sci STKE. 2007 Oct 16;2007(408):pe57. PubMed Europe PMC Scholia
  226. Phosphatidylserine and phosphatidylethanolamine in mammalian cells: two metabolically related aminophospholipids. Vance JE. J Lipid Res. 2008 Jul;49(7):1377–87. PubMed Europe PMC Scholia
  227. Phosphatidylcholine and choline homeostasis. Li Z, Vance DE. J Lipid Res. 2008 Jun;49(6):1187–94. PubMed Europe PMC Scholia
  228. Transcriptional regulation of phosphatidylcholine biosynthesis. Sugimoto H, Banchio C, Vance DE. Prog Lipid Res. 2008 May;47(3):204–20. PubMed Europe PMC Scholia
  229. Type II phosphatidylinositol 4-kinase(s) in cell signaling cascades. Sinha RK, Subrahmanyam G. Indian J Biochem Biophys. 2007 Oct;44(5):289–94. PubMed Europe PMC Scholia
  230. Cardiolipin, the heart of mitochondrial metabolism. Houtkooper RH, Vaz FM. Cell Mol Life Sci. 2008 Aug;65(16):2493–506. PubMed Europe PMC Scholia
  231. Diacylglycerol acyltransferases: Potential roles as pharmacological targets. Zammit VA, Buckett LK, Turnbull AV, Wure H, Proven A. Pharmacol Ther. 2008 Jun;118(3):295–302. PubMed Europe PMC Scholia
  232. The multiple roles of PtdIns(4)P -- not just the precursor of PtdIns(4,5)P2. D’Angelo G, Vicinanza M, Di Campli A, De Matteis MA. J Cell Sci. 2008 Jun 15;121(Pt 12):1955–63. PubMed Europe PMC Scholia
  233. Two pathways for lysophosphatidic acid production. Aoki J, Inoue A, Okudaira S. Biochim Biophys Acta. 2008 Sep;1781(9):513–8. PubMed Europe PMC Scholia
  234. Thematic Review Series: Glycerolipids. Multiple roles for lipins/phosphatidate phosphatase enzymes in lipid metabolism. Reue K, Brindley DN. J Lipid Res. 2008 Dec;49(12):2493–503. PubMed Europe PMC Scholia
  235. Breast cancer is associated with an increase in the activity and expression of cholinephosphotransferase in rats. Sinha Roy S, Mukhopadhyay S, Mukherjee S, Das SK. Life Sci. 2008 Nov 7;83(19–20):661–5. PubMed Europe PMC Scholia
  236. Platelet activating factor (PAF) and activity of its biosynthetic and catabolic enzymes in blood and leukocytes of male patients with newly diagnosed heart failure. Detopoulou P, Nomikos T, Fragopoulou E, Antonopoulou S, Kotroyiannis I, Vassiliadou C, et al. Clin Biochem. 2009 Jan;42(1–2):44–9. PubMed Europe PMC Scholia
  237. Phosphatidate degradation: phosphatidate phosphatases (lipins) and lipid phosphate phosphatases. Brindley DN, Pilquil C, Sariahmetoglu M, Reue K. Biochim Biophys Acta. 2009 Sep;1791(9):956–61. PubMed Europe PMC Scholia
  238. Functional characterization of the human 1-acylglycerol-3-phosphate-O-acyltransferase isoform 10/glycerol-3-phosphate acyltransferase isoform 3. Sukumaran S, Barnes RI, Garg A, Agarwal AK. J Mol Endocrinol. 2009 Jun;42(6):469–78. PubMed Europe PMC Scholia
  239. Role of phosphoinositol 4,5-bisphosphate and diacylglycerol in regulating native TRPC channel proteins in vascular smooth muscle. Large WA, Saleh SN, Albert AP. Cell Calcium. 2009 Jun;45(6):574–82. PubMed Europe PMC Scholia
  240. The physicochemical properties of cardiolipin bilayers and cardiolipin-containing lipid membranes. Lewis RNAH, McElhaney RN. Biochim Biophys Acta. 2009 Oct;1788(10):2069–79. PubMed Europe PMC Scholia
  241. Biophysics and function of phosphatidic acid: a molecular perspective. Kooijman EE, Burger KNJ. Biochim Biophys Acta. 2009 Sep;1791(9):881–8. PubMed Europe PMC Scholia
  242. Citicoline (CDP-choline): What role in the treatment of complications of infectious diseases. Jambou R, El-Assaad F, Combes V, Grau GE. Int J Biochem Cell Biol. 2009 Jul;41(7):1467–70. PubMed Europe PMC Scholia
  243. The role of cardiolipin in the structural organization of mitochondrial membranes. Schlame M, Ren M. Biochim Biophys Acta. 2009 Oct;1788(10):2080–3. PubMed Europe PMC Scholia
  244. Cardiolipin, a critical determinant of mitochondrial carrier protein assembly and function. Claypool SM. Biochim Biophys Acta. 2009 Oct;1788(10):2059–68. PubMed Europe PMC Scholia
  245. Cardiolipin acts as a mitochondrial signalling platform to launch apoptosis. Schug ZT, Gottlieb E. Biochim Biophys Acta. 2009 Oct;1788(10):2022–31. PubMed Europe PMC Scholia
  246. Cardiolipin and mitochondrial carriers. Klingenberg M. Biochim Biophys Acta. 2009 Oct;1788(10):2048–58. PubMed Europe PMC Scholia
  247. Phosphatidic acid signaling regulation of Ras superfamily of small guanosine triphosphatases. Zhang Y, Du G. Biochim Biophys Acta. 2009 Sep;1791(9):850–5. PubMed Europe PMC Scholia
  248. Glycerol-3-phosphate acyltransferase 4 gene is involved in mouse spermatogenesis. Qiu Q, Liu G, Li W, Shi Q, Zhu F, Lu G. Acta Biochim Biophys Sin (Shanghai). 2009 Aug;41(8):668–76. PubMed Europe PMC Scholia
  249. Elimination of the CDP-ethanolamine pathway disrupts hepatic lipid homeostasis. Leonardi R, Frank MW, Jackson PD, Rock CO, Jackowski S. J Biol Chem. 2009 Oct 2;284(40):27077–89. PubMed Europe PMC Scholia
  250. PIP5K-driven PtdIns(4,5)P2 synthesis: regulation and cellular functions. van den Bout I, Divecha N. J Cell Sci. 2009 Nov 1;122(Pt 21):3837–50. PubMed Europe PMC Scholia
  251. Cholesterol and peroxidized cardiolipin in mitochondrial membrane properties, permeabilization and cell death. Montero J, Mari M, Colell A, Morales A, Basañez G, Garcia-Ruiz C, et al. Biochim Biophys Acta. 2010;1797(6–7):1217–24. PubMed Europe PMC Scholia
  252. The platelet activating factor (PAF) signaling cascade in systemic inflammatory responses. Yost CC, Weyrich AS, Zimmerman GA. Biochimie. 2010 Jun;92(6):692–7. PubMed Europe PMC Scholia
  253. Oxidative stress, mitochondrial bioenergetics, and cardiolipin in aging. Paradies G, Petrosillo G, Paradies V, Ruggiero FM. Free Radic Biol Med. 2010 May 15;48(10):1286–95. PubMed Europe PMC Scholia
  254. Lipid kinases: charging PtdIns(4,5)P2 synthesis. Divecha N. Curr Biol. 2010 Feb 23;20(4):R154-7. PubMed Europe PMC Scholia
  255. The distribution and function of phosphatidylserine in cellular membranes. Leventis PA, Grinstein S. Annu Rev Biophys. 2010;39:407–27. PubMed Europe PMC Scholia
  256. The Kennedy pathway--De novo synthesis of phosphatidylethanolamine and phosphatidylcholine. Gibellini F, Smith TK. IUBMB Life. 2010 Jun;62(6):414–28. PubMed Europe PMC Scholia
  257. One lipid, multiple functions: how various pools of PI(4,5)P(2) are created in the plasma membrane. Kwiatkowska K. Cell Mol Life Sci. 2010 Dec;67(23):3927–46. PubMed Europe PMC Scholia
  258. Choline kinase and its function. Wu G, Vance DE. Biochem Cell Biol. 2010 Aug;88(4):559–64. PubMed Europe PMC Scholia
  259. Lysophosphatidic acid is a lipid mediator with wide range of biological activities. Biosynthetic pathways and mechanism of action. Berdichevets IN, Tyazhelova TV, Shimshilashvili KR, Rogaev EI. Biochemistry (Mosc). 2010 Sep;75(9):1088–97. PubMed Europe PMC Scholia
  260. Plasmalogen synthesis is regulated via alkyl-dihydroxyacetonephosphate-synthase by amyloid precursor protein processing and is affected in Alzheimer’s disease. Grimm MOW, Kuchenbecker J, Rothhaar TL, Grösgen S, Hundsdörfer B, Burg VK, et al. J Neurochem. 2011 Mar;116(5):916–25. PubMed Europe PMC Scholia
  261. Coordination of Golgi functions by phosphatidylinositol 4-kinases. Graham TR, Burd CG. Trends Cell Biol. 2011 Feb;21(2):113–21. PubMed Europe PMC Scholia
  262. Phosphoethanolamine methyltransferases in phosphocholine biosynthesis: functions and potential for antiparasite therapy. Bobenchik AM, Augagneur Y, Hao B, Hoch JC, Ben Mamoun C. FEMS Microbiol Rev. 2011 Jul;35(4):609–19. PubMed Europe PMC Scholia
  263. Cholesterol, cardiolipin, and mitochondria permeabilisation. Lucken-Ardjomande Hasler S. Anticancer Agents Med Chem. 2012 May;12(4):329–39. PubMed Europe PMC Scholia
  264. CDP-choline as a biological supplement during neurorecovery: a focused review. Arenth PM, Russell KC, Ricker JH, Zafonte RD. PM R. 2011 Jun;3(6 Suppl 1):S123-31. PubMed Europe PMC Scholia
  265. Metabolism, function and mass spectrometric analysis of bis(monoacylglycero)phosphate and cardiolipin. Scherer M, Schmitz G. Chem Phys Lipids. 2011 Sep;164(6):556–62. PubMed Europe PMC Scholia
  266. Role of phosphatidylcholine during neuronal differentiation. Paoletti L, Elena C, Domizi P, Banchio C. IUBMB Life. 2011 Sep;63(9):714–20. PubMed Europe PMC Scholia
  267. Phosphatidylcholine biosynthesis and lipoprotein metabolism. Cole LK, Vance JE, Vance DE. Biochim Biophys Acta. 2012 May;1821(5):754–61. PubMed Europe PMC Scholia
  268. The complexity of cardiolipin in health and disease. Claypool SM, Koehler CM. Trends Biochem Sci. 2012 Jan;37(1):32–41. PubMed Europe PMC Scholia
  269. PIP3 regulation as promising targeted therapy of mast-cell-mediated diseases. Shenker BJ, Ali H, Boesze-Battaglia K. Curr Pharm Des. 2011 Nov;17(34):3815–22. PubMed Europe PMC Scholia
  270. Putting the pH into phosphatidic acid signaling. Shin JJH, Loewen CJR. BMC Biol. 2011 Dec 2;9:85. PubMed Europe PMC Scholia
  271. Mice deficient in glycerol-3-phosphate acyltransferase-1 have a reduced susceptibility to liver cancer. Ellis JM, Paul DS, Depetrillo MA, Singh BP, Malarkey DE, Coleman RA. Toxicol Pathol. 2012 Apr;40(3):513–21. PubMed Europe PMC Scholia
  272. Membrane topology of murine glycerol-3-phosphate acyltransferase 2. Nakagawa T, Harada N, Miyamoto A, Kawanishi Y, Yoshida M, Shono M, et al. Biochem Biophys Res Commun. 2012 Feb 17;418(3):506–11. PubMed Europe PMC Scholia
  273. Sensing phosphatidylserine in cellular membranes. Kay JG, Grinstein S. Sensors (Basel). 2011;11(2):1744–55. PubMed Europe PMC Scholia
  274. Phosphatidylinositol 4, 5 bisphosphate and the actin cytoskeleton. Zhang L, Mao YS, Janmey PA, Yin HL. Subcell Biochem. 2012;59:177–215. PubMed Europe PMC Scholia
  275. Free radical oxidation of cardiolipin: chemical mechanisms, detection and implication in apoptosis, mitochondrial dysfunction and human diseases. Yin H, Zhu M. Free Radic Res. 2012 Aug;46(8):959–74. PubMed Europe PMC Scholia
  276. Mitochondria: signaling with phosphatidic acid. Yang CY, Frohman MA. Int J Biochem Cell Biol. 2012 Aug;44(8):1346–50. PubMed Europe PMC Scholia
  277. Phosphatidylinositol 4-kinases, phosphatidylinositol 4-phosphate and cancer. Waugh MG. Cancer Lett. 2012 Dec 28;325(2):125–31. PubMed Europe PMC Scholia
  278. Lysophosphatidic acid (LPA) and its receptors: role in airway inflammation and remodeling. Zhao Y, Natarajan V. Biochim Biophys Acta. 2013 Jan;1831(1):86–92. PubMed Europe PMC Scholia
  279. Physiological roles of phosphatidylethanolamine N-methyltransferase. Vance DE. Biochim Biophys Acta. 2013 Mar;1831(3):626–32. PubMed Europe PMC Scholia
  280. Lysophosphatidic acid: a potential mediator of osteoblast-osteoclast signaling in bone. Sims SM, Panupinthu N, Lapierre DM, Pereverzev A, Dixon SJ. Biochim Biophys Acta. 2013 Jan;1831(1):109–16. PubMed Europe PMC Scholia
  281. Phosphatidate phosphatase, a key regulator of lipid homeostasis. Pascual F, Carman GM. Biochim Biophys Acta. 2013 Mar;1831(3):514–22. PubMed Europe PMC Scholia
  282. Formation and function of phosphatidylserine and phosphatidylethanolamine in mammalian cells. Vance JE, Tasseva G. Biochim Biophys Acta. 2013 Mar;1831(3):543–54. PubMed Europe PMC Scholia
  283. Lysophosphatidic acid: chemical signature of neuropathic pain. Ueda H, Matsunaga H, Olaposi OI, Nagai J. Biochim Biophys Acta. 2013 Jan;1831(1):61–73. PubMed Europe PMC Scholia
  284. Signal transduction pathways involving phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate: convergences and divergences among eukaryotic kingdoms. Delage E, Puyaubert J, Zachowski A, Ruelland E. Prog Lipid Res. 2013 Jan;52(1):1–14. PubMed Europe PMC Scholia
  285. Phosphatidylcholine and the CDP-choline cycle. Fagone P, Jackowski S. Biochim Biophys Acta. 2013 Mar;1831(3):523–32. PubMed Europe PMC Scholia
  286. Emerging roles of secreted phospholipase A(2) enzymes: an update. Murakami M, Lambeau G. Biochimie. 2013 Jan;95(1):43–50. PubMed Europe PMC Scholia
  287. Phosphatidylinositol 4-kinases and PI4P metabolism in the nervous system: roles in psychiatric and neurological diseases. Clayton EL, Minogue S, Waugh MG. Mol Neurobiol. 2013 Feb;47(1):361–72. PubMed Europe PMC Scholia
  288. Structure of glycerol-3-phosphate dehydrogenase (GPD1) from Saccharomyces cerevisiae at 2.45 Å resolution. Alarcon DA, Nandi M, Carpena X, Fita I, Loewen PC. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Nov 1;68(Pt 11):1279–83. PubMed Europe PMC Scholia
  289. The function and the role of the mitochondrial glycerol-3-phosphate dehydrogenase in mammalian tissues. Mráček T, Drahota Z, Houštěk J. Biochim Biophys Acta. 2013 Mar;1827(3):401–10. PubMed Europe PMC Scholia
  290. Emerging roles of intracellular phosphatidylserine (PS) in membrane traffic. Taguchi T, Arai H. Seikagaku. 2012 Oct;84(10):844–8. PubMed Europe PMC Scholia
  291. Mucosal protection by phosphatidylcholine. Stremmel W, Ehehalt R, Staffer S, Stoffels S, Mohr A, Karner M, et al. Dig Dis. 2012;30 Suppl 3:85–91. PubMed Europe PMC Scholia
  292. The role of phosphatidylcholine and choline metabolites to cell proliferation and survival. Ridgway ND. Crit Rev Biochem Mol Biol. 2013;48(1):20–38. PubMed Europe PMC Scholia
  293. Biosynthetic pathways of bioactive N-acylethanolamines in brain. Tsuboi K, Ikematsu N, Uyama T, Deutsch DG, Tokumura A, Ueda N. CNS Neurol Disord Drug Targets. 2013 Feb 1;12(1):7–16. PubMed Europe PMC Scholia
  294. Lysophosphatidic acid (LPA) signalling in cell migration and cancer invasion: a focussed review and analysis of LPA receptor gene expression on the basis of more than 1700 cancer microarrays. Willier S, Butt E, Grunewald TGP. Biol Cell. 2013 Aug;105(8):317–33. PubMed Europe PMC Scholia
  295. Phosphatidylinositol-4-phosphate: the Golgi and beyond. De Matteis MA, Wilson C, D’Angelo G. Bioessays. 2013 Jul;35(7):612–22. PubMed Europe PMC Scholia
  296. Phosphatidylinositol-3,4,5-trisphosphate: tool of choice for class I PI 3-kinases. Salamon RS, Backer JM. Bioessays. 2013 Jul;35(7):602–11. PubMed Europe PMC Scholia
  297. Phosphatidylserine-mediated cellular signaling. Kay JG, Grinstein S. Adv Exp Med Biol. 2013;991:177–93. PubMed Europe PMC Scholia
  298. Cardiolipin-mediated cellular signaling. Patil VA, Greenberg ML. Adv Exp Med Biol. 2013;991:195–213. PubMed Europe PMC Scholia